Ligands bind to Sortilin in the tunnel of a ten-bladed beta-propeller domain
about
Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling.Lysosomal sorting of amyloid-β by the SORLA receptor is impaired by a familial Alzheimer's disease mutationMolecular and Structural Insight into proNGF Engagement of p75NTR and SortilinIdentification of the first small-molecule ligand of the neuronal receptor sortilin and structure determination of the receptor-ligand complexCrystal structure of the eukaryotic translation initiation factor 2A from Schizosaccharomyces pombeRevisiting the structure of the Vps10 domain of human sortilin and its interaction with neurotensinMolecular architecture of the 40S⋅eIF1⋅eIF3 translation initiation complexRisk factor SORL1: from genetic association to functional validation in Alzheimer's diseaseSortilin, encoded by the cardiovascular risk gene SORT1, and its suggested functions in cardiovascular diseaseA Genetic Variant of the Sortilin 1 Gene is Associated with Reduced Risk of Alzheimer's DiseaseSortilin, a novel APOE receptor implicated in Alzheimer diseaseTargeted manipulation of the sortilin-progranulin axis rescues progranulin haploinsufficiencyMannose 6-phosphate receptor and sortilin mediated endocytosis of α-galactosidase A in kidney endothelial cellsIdentification of a linear epitope in sortilin that partakes in pro-neurotrophin binding.Vacuolar protein sorting receptor in Giardia lamblia.Sequence and structural analysis of the Asp-box motif and Asp-box beta-propellers; a widespread propeller-type characteristic of the Vps10 domain family and several glycoside hydrolase familiesProneurotrophin-3 is a neuronal apoptotic ligand: evidence for retrograde-directed cell killing.Understanding proneurotrophin actions: Recent advances and challenges.Secretion of a foreign protein from budding yeasts is enhanced by cotranslational translocation and by suppression of vacuolar targeting.Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin.β-Propeller blades as ancestral peptides in protein evolution.Forward targeting of Toxoplasma gondii proproteins to the micronemes involves conserved aliphatic amino acids.Sortilin associates with transforming growth factor-beta family proteins to enhance lysosome-mediated degradation.Targeting sortilin in immune cells reduces proinflammatory cytokines and atherosclerosis.Pro-nerve growth factor induces autocrine stimulation of breast cancer cell invasion through tropomyosin-related kinase A (TrkA) and sortilin protein.Endosomal sorting by Semaphorin 4A in retinal pigment epithelium supports photoreceptor survival.Mapping of the interaction site between sortilin and the p75 neurotrophin receptor reveals a regulatory role for the sortilin intracellular domain in p75 neurotrophin receptor shedding and apoptosisActivation of a synapse weakening pathway by human Val66 but not Met66 pro-brain-derived neurotrophic factor (proBDNF)Structural and functional analysis of APOA5 mutations identified in patients with severe hypertriglyceridemia.ProBDNF and mature BDNF as punishment and reward signals for synapse elimination at mouse neuromuscular junctionsVal66Met polymorphism of BDNF alters prodomain structure to induce neuronal growth cone retractionIncreased serum levels of sortilin are associated with depression and correlated with BDNF and VEGF.Proteolytic processing of the p75 neurotrophin receptor: A prerequisite for signalling?: Neuronal life, growth and death signalling are crucially regulated by intra-membrane proteolysis and trafficking of p75(NTR).Sortilin and SorLA regulate neuronal sorting of trophic and dementia-linked proteins.Sorting receptor sortilin-a culprit in cardiovascular and neurological diseases.Neuronal brain-derived neurotrophic factor is synthesized in excess, with levels regulated by sortilin-mediated trafficking and lysosomal degradation.Sorting receptor SORLA: cellular mechanisms and implications for disease.Sortilin facilitates signaling of ciliary neurotrophic factor and related helical type 1 cytokines targeting the gp130/leukemia inhibitory factor receptor beta heterodimer.Commentary: Regulating proNGF action: multiple targets for therapeutic interventionPrions amplify through degradation of the VPS10P sorting receptor sortilin.
P2860
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P2860
Ligands bind to Sortilin in the tunnel of a ten-bladed beta-propeller domain
description
2009 nî lūn-bûn
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2009 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Ligands bind to Sortilin in the tunnel of a ten-bladed beta-propeller domain
@ast
Ligands bind to Sortilin in the tunnel of a ten-bladed beta-propeller domain
@en
Ligands bind to Sortilin in the tunnel of a ten-bladed beta-propeller domain
@nl
type
label
Ligands bind to Sortilin in the tunnel of a ten-bladed beta-propeller domain
@ast
Ligands bind to Sortilin in the tunnel of a ten-bladed beta-propeller domain
@en
Ligands bind to Sortilin in the tunnel of a ten-bladed beta-propeller domain
@nl
prefLabel
Ligands bind to Sortilin in the tunnel of a ten-bladed beta-propeller domain
@ast
Ligands bind to Sortilin in the tunnel of a ten-bladed beta-propeller domain
@en
Ligands bind to Sortilin in the tunnel of a ten-bladed beta-propeller domain
@nl
P50
P3181
P356
P1476
Ligands bind to Sortilin in the tunnel of a ten-bladed beta-propeller domain
@en
P2093
Claus M Petersen
P2888
P3181
P356
10.1038/NSMB.1543
P407
P577
2009-01-04T00:00:00Z
P5875
P6179
1033088781