Proteolytic processing of the p75 neurotrophin receptor: A prerequisite for signalling?: Neuronal life, growth and death signalling are crucially regulated by intra-membrane proteolysis and trafficking of p75(NTR).
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A novel antagonist of p75NTR reduces peripheral expansion and CNS trafficking of pro-inflammatory monocytes and spares function after traumatic brain injury.A new role under sortilin's belt in cancerTargeted delivery of brain-derived neurotrophic factor for the treatment of blindness and deafness.Small molecule p75NTR ligands reduce pathological phosphorylation and misfolding of tau, inflammatory changes, cholinergic degeneration, and cognitive deficits in AβPP(L/S) transgenic mice.A small molecule p75NTR ligand normalizes signalling and reduces Huntington's disease phenotypes in R6/2 and BACHD mice.Anti-proliferative role of recombinant lethal toxin of Bacillus anthracis on primary mammary ductal carcinoma cells revealing its therapeutic potential.Resilience of precuneus neurotrophic signaling pathways despite amyloid pathology in prodromal Alzheimer's disease.Endogenous neurotrophins and Trk signaling in diffuse large B cell lymphoma cell lines are involved in sensitivity to rituximab-induced apoptosis.Small-molecule modulation of neurotrophin receptors: a strategy for the treatment of neurological disease.CARP-1 functional mimetics: a novel class of small molecule inhibitors of medulloblastoma cell growthLigand-induced dynamics of neurotrophin receptors investigated by single-molecule imaging approaches.BDNF-TrkB axis regulates migration of the lateral line primordium and modulates the maintenance of mechanoreceptor progenitors.Neurotrophins regulate ApoER2 proteolysis through activation of the Trk signaling pathway.Immunization Against Specific Fragments of Neurotrophin p75 Receptor Protects Forebrain Cholinergic Neurons in the Olfactory Bulbectomized MiceMapping of the interaction site between sortilin and the p75 neurotrophin receptor reveals a regulatory role for the sortilin intracellular domain in p75 neurotrophin receptor shedding and apoptosisThe effects of transmembrane sequence and dimerization on cleavage of the p75 neurotrophin receptor by γ-secretaseGlioma invasion mediated by the p75 neurotrophin receptor (p75(NTR)/CD271) requires regulated interaction with PDLIM1.An intracellular domain fragment of the p75 neurotrophin receptor (p75(NTR)) enhances tropomyosin receptor kinase A (TrkA) receptor functionThe Inorganic Side of NGF: Copper(II) and Zinc(II) Affect the NGF Mimicking Signaling of the N-Terminus Peptides Encompassing the Recognition Domain of TrkA Receptor.Sortilin and SorLA regulate neuronal sorting of trophic and dementia-linked proteins.Fragment C of tetanus toxin: new insights into its neuronal signaling pathway.Pro-neurotrophins, sortilin, and nociception.From genes to pain: nerve growth factor and hereditary sensory and autonomic neuropathy type V.Sorting receptor sortilin-a culprit in cardiovascular and neurological diseases.Dynamic nature of the p75 neurotrophin receptor in response to injury and diseaseCharacterization of novel biomarkers in selecting for subtype specific medulloblastoma phenotypes.Neurotrophin signaling in cancer stem cells.Amyloid beta₁₋₄₂ (Aβ₄₂) up-regulates the expression of sortilin via the p75(NTR)/RhoA signaling pathway.Extracellular cleavage of the p75 neurotrophin receptor is implicated in its pro-survival effect in breast cancer cells.p75 Neurotrophin Receptor in the Skin: Beyond Its Neurotrophic Function.Synapsins Are Downstream Players of the BDNF-Mediated Axonal Growth.Silencing p75(NTR) prevents proNGF-induced endothelial cell death and development of acellular capillaries in rat retina.G-Protein-Coupled Inwardly Rectifying Potassium (GIRK) Channel Activation by the p75 Neurotrophin Receptor Is Required for Amyloid β Toxicity.Structural Basis of p75 Transmembrane Domain Dimerization.Dissecting the role of sortilin receptor signaling in neurodegeneration induced by NGF deprivation.Transient denervation of viable myocardium after myocardial infarction does not alter arrhythmia susceptibility.Role of BDNF/TrkB pathway in the visual system: Therapeutic implications for glaucoma.The TrkA receptor mediates experimental thermal hyperalgesia produced by nerve growth factor: Modulation by the p75 neurotrophin receptor.Modulating Neurotrophin Receptor Signaling as a Therapeutic Strategy for Huntington's Disease.Up-regulation of sortilin mediated by amyloid-β and p75(NTR): safety lies in the middle course.
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Proteolytic processing of the p75 neurotrophin receptor: A prerequisite for signalling?: Neuronal life, growth and death signalling are crucially regulated by intra-membrane proteolysis and trafficking of p75(NTR).
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 30 June 2011
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Proteolytic processing of the ...... s and trafficking of p75(NTR).
@en
Proteolytic processing of the ...... s and trafficking of p75(NTR).
@nl
type
label
Proteolytic processing of the ...... s and trafficking of p75(NTR).
@en
Proteolytic processing of the ...... s and trafficking of p75(NTR).
@nl
prefLabel
Proteolytic processing of the ...... s and trafficking of p75(NTR).
@en
Proteolytic processing of the ...... s and trafficking of p75(NTR).
@nl
P2860
P50
P356
P1433
P1476
Proteolytic processing of the ...... s and trafficking of p75(NTR).
@en
P2093
Sune Skeldal
P2860
P304
P356
10.1002/BIES.201100036
P407
P577
2011-06-30T00:00:00Z