Molecular and Structural Insight into proNGF Engagement of p75NTR and Sortilin
about
Brain-Derived Neurotrophic Factor: Three Ligands, Many ActionsPrinciples of antibody-mediated TNF receptor activationCytokine Spatzle binds to the Drosophila immunoreceptor Toll with a neurotrophin-like specificity and couples receptor activationConformational plasticity of proNGFStructural characterization of the self-association of the death domain of p75(NTR.)Precursor of brain-derived neurotrophic factor (proBDNF) forms a complex with Huntingtin-associated protein-1 (HAP1) and sortilin that modulates proBDNF trafficking, degradation, and processingTaking pain out of NGF: a "painless" NGF mutant, linked to hereditary sensory autonomic neuropathy type V, with full neurotrophic activityIdentification of a linear epitope in sortilin that partakes in pro-neurotrophin binding.Small-molecule modulation of neurotrophin receptors: a strategy for the treatment of neurological disease.BNN27, a 17-Spiroepoxy Steroid Derivative, Interacts With and Activates p75 Neurotrophin Receptor, Rescuing Cerebellar Granule Neurons from Apoptosis.Ligand-induced dynamics of neurotrophin receptors investigated by single-molecule imaging approaches.Pro-nerve growth factor induces autocrine stimulation of breast cancer cell invasion through tropomyosin-related kinase A (TrkA) and sortilin protein.Detection of p75NTR Trimers: Implications for Receptor Stoichiometry and Activation.The effects of transmembrane sequence and dimerization on cleavage of the p75 neurotrophin receptor by γ-secretaseVal66Met polymorphism of BDNF alters prodomain structure to induce neuronal growth cone retractionProteolytic processing of the p75 neurotrophin receptor: A prerequisite for signalling?: Neuronal life, growth and death signalling are crucially regulated by intra-membrane proteolysis and trafficking of p75(NTR).The molecular interplay between endocannabinoid and neurotrophin signals in the nervous system and beyond.Conformational Rigidity within Plasticity Promotes Differential Target Recognition of Nerve Growth Factor.Structural Biology and Evolution of the TGF-β FamilyNeurotrophin Signaling and Stem Cells-Implications for Neurodegenerative Diseases and Stem Cell Therapy.Growth factors and hormones pro-peptides: the unexpected adventures of the BDNF prodomain.Neuronal growth cone retraction relies on proneurotrophin receptor signaling through Rac.Messenger RNA expression patterns of p75 neurotrophin receptor and tropomyosin-receptor-kinase A following spinal cord injuryNeurotrophic factor changes in the rat thick skin following chronic constriction injury of the sciatic nerveImbalance of the Nerve Growth Factor and Its Precursor: Implication in Diabetic Retinopathy.Trk Receptors and Neurotrophin Cross-Interactions: New Perspectives Toward Manipulating Therapeutic Side-EffectsNerve growth factor inhibitor with novel-binding domain demonstrates nanomolar efficacy in both cell-based and cell-free assay systems.Structural Basis of p75 Transmembrane Domain Dimerization.Neuroprotective Effects of Exercise Treatments After Injury: The Dual Role of Neurotrophic Factors.Pro-region engineering for improved yeast display and secretion of brain derived neurotrophic factor.Low pH-induced conformational change and dimerization of sortilin triggers endocytosed ligand release.A Novel Neuroprotective Mechanism for Lithium That Prevents Association of the p75NTR-Sortilin Receptor Complex and Attenuates proNGF-Induced Neuronal Death In Vitro and In Vivo.Conformational characterization of nerve growth factor-β reveals that its regulatory pro-part domain stabilizes three loop regions in its mature part.proBDNF inhibits the proliferation and migration of OLN‑93 oligodendrocytes
P2860
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P2860
Molecular and Structural Insight into proNGF Engagement of p75NTR and Sortilin
description
2010 nî lūn-bûn
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2010 թուականի Մարտին հրատարակուած գիտական յօդուած
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2010 թվականի մարտին հրատարակված գիտական հոդված
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2010年の論文
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2010年論文
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2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
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name
Molecular and Structural Insight into proNGF Engagement of p75NTR and Sortilin
@ast
Molecular and Structural Insight into proNGF Engagement of p75NTR and Sortilin
@en
Molecular and Structural Insight into proNGF Engagement of p75NTR and Sortilin
@nl
type
label
Molecular and Structural Insight into proNGF Engagement of p75NTR and Sortilin
@ast
Molecular and Structural Insight into proNGF Engagement of p75NTR and Sortilin
@en
Molecular and Structural Insight into proNGF Engagement of p75NTR and Sortilin
@nl
prefLabel
Molecular and Structural Insight into proNGF Engagement of p75NTR and Sortilin
@ast
Molecular and Structural Insight into proNGF Engagement of p75NTR and Sortilin
@en
Molecular and Structural Insight into proNGF Engagement of p75NTR and Sortilin
@nl
P2093
P2860
P1476
Molecular and Structural Insight into proNGF Engagement of p75NTR and Sortilin
@en
P2093
Barbara L Hempstead
Engin Ozkan
K Christopher Garcia
Matthew Light
Risa Torkin
P2860
P304
P356
10.1016/J.JMB.2009.12.030
P407
P577
2010-03-05T00:00:00Z