Synthesis, kinase inhibitory potencies, and in vitro antiproliferative evaluation of new Pim kinase inhibitors
about
Pim-2 phosphorylation of p21(Cip1/WAF1) enhances its stability and inhibits cell proliferation in HCT116 cellsZMYND11 links histone H3.3K36me3 to transcription elongation and tumour suppressionPim Kinases Promote Migration and Metastatic Growth of Prostate Cancer XenograftsTricyclic Benzo[cd]azulenes selectively inhibit activities of Pim kinases and restrict growth of Epstein-Barr virus-transformed cells7,8-Dichloro-1-oxo-β-carbolines as a Versatile Scaffold for the Development of Potent and Selective Kinase Inhibitors with Unusual Binding ModesPIM1 kinase as a target for cancer therapySmall molecule inhibitors of PIM1 kinase: July 2009 to February 2013 patent updatePim-selective inhibitor DHPCC-9 reveals Pim kinases as potent stimulators of cancer cell migration and invasionPathophysiological roles of Pim-3 kinase in pancreatic cancer development and progression.The Pim protein kinases regulate energy metabolism and cell growthEffect of single amino acid substitution observed in cancer on Pim-1 kinase thermodynamic stability and structureG9a-mediated methylation of ERα links the PHF20/MOF histone acetyltransferase complex to hormonal gene expression.Phosphorylation of Notch1 by Pim kinases promotes oncogenic signaling in breast and prostate cancer cells.Why target PIM1 for cancer diagnosis and treatment?Roles of Pim-3, a novel survival kinase, in tumorigenesis.Insights from Pim1 structure for anti-cancer drug design.Identification of a phenanthrene derivative as a potent anticancer drug with Pim kinase inhibitory activity.Identification of novel inhibitors for Pim-1 kinase using pharmacophore modeling based on a novel method for selecting pharmacophore generation subsets.Kaposi's sarcoma herpesvirus lytic replication compromises apoptotic response to p53 reactivation in virus-induced lymphomas.
P2860
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P2860
Synthesis, kinase inhibitory potencies, and in vitro antiproliferative evaluation of new Pim kinase inhibitors
description
2009 nî lūn-bûn
@nan
2009 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Synthesis, kinase inhibitory p ...... n of new Pim kinase inhibitors
@ast
Synthesis, kinase inhibitory p ...... n of new Pim kinase inhibitors
@en
Synthesis, kinase inhibitory p ...... n of new Pim kinase inhibitors
@nl
type
label
Synthesis, kinase inhibitory p ...... n of new Pim kinase inhibitors
@ast
Synthesis, kinase inhibitory p ...... n of new Pim kinase inhibitors
@en
Synthesis, kinase inhibitory p ...... n of new Pim kinase inhibitors
@nl
prefLabel
Synthesis, kinase inhibitory p ...... n of new Pim kinase inhibitors
@ast
Synthesis, kinase inhibitory p ...... n of new Pim kinase inhibitors
@en
Synthesis, kinase inhibitory p ...... n of new Pim kinase inhibitors
@nl
P2093
P50
P3181
P356
P1476
Synthesis, kinase inhibitory p ...... n of new Pim kinase inhibitors
@en
P2093
Alex N Bullock
Jenny Bain
Michelle Prudhomme
Philip Cohen
Rufine Akué-Gédu
Stéphane Azzaro
P304
P3181
P356
10.1021/JM901018F
P407
P577
2009-10-22T00:00:00Z