Main Immunogenic Region Structure Promotes Binding of Conformation-Dependent Myasthenia Gravis Autoantibodies, Nicotinic Acetylcholine Receptor Conformation Maturation, and Agonist Sensitivity - Wikidata - awgldk - TriplyDB

Main Immunogenic Region Structure Promotes Binding of Conformation-Dependent Myasthenia Gravis Autoantibodies, Nicotinic Acetylcholine Receptor Conformation Maturation, and Agonist Sensitivity

Main Immunogenic Region Structure Promotes Binding of Conformation-Dependent Myasthenia Gravis Autoantibodies, Nicotinic Acetylcholine Receptor Conformation Maturation, and Agonist Sensitivity

http://www.wikidata.org/entity/Q27658065

about

Neuronal Nicotinic Acetylcholine Receptor Structure and Function and Response to Nicotine Mapping autoantigen epitopes: molecular insights into autoantibody-associated disorders of the nervous system Chemical chaperones exceed the chaperone effects of RIC-3 in promoting assembly of functional α7 AChRs Structural insights into the molecular mechanisms of myasthenia gravis and their therapeutic implications.Hinge-deleted IgG4 blocker therapy for acetylcholine receptor myasthenia gravis in rhesus monkeys.Improved methodology to obtain large quantities of correctly folded recombinant N-terminal extracellular domain of the human muscle acetylcholine receptor for inducing experimental autoimmune myasthenia gravis in rats.Mechanisms of Autoantibody-Induced Pathology.Specific immunotherapy of experimental myasthenia gravis by a novel mechanism.Fusion protein of single-chain variable domain fragments for treatment of myasthenia gravis.In vivo adsorption of autoantibodies in myasthenia gravis using Nanodisc-incorporated acetylcholine receptor.Antigen-specific immunotherapeutic vaccine for experimental autoimmune myasthenia gravis Myasthenogenicity of the main immunogenic region and endogenous muscle nicotinic acetylcholine receptors Myasthenogenicity of the main immunogenic region.MuSK IgG4 autoantibodies cause myasthenia gravis by inhibiting binding between MuSK and Lrp4.In pursuit of the high-resolution structure of nicotinic acetylcholine receptors.Antibody effector mechanisms in myasthenia gravis-pathogenesis at the neuromuscular junction.Assembly of nicotinic and other Cys-loop receptors.The molecular anatomy of human Hsp60 and its similarity with that of bacterial orthologs and acetylcholine receptor reveal a potential pathogenetic role of anti-chaperonin immunity in myasthenia gravis.Myasthenia gravis in dogs with an emphasis on treatment and critical care management.Acetylcholine receptor-induced experimental myasthenia gravis: what have we learned from animal models after three decades?Pathogenic immune mechanisms at the neuromuscular synapse: the role of specific antibody-binding epitopes in myasthenia gravis.A Novel Approach to Reinstating Tolerance in Experimental Autoimmune Myasthenia Gravis Using a Targeted Fusion Protein, mCTA1-T146.Analysis of peripheral B cells and autoantibodies against the anti-nicotinic acetylcholine receptor derived from patients with myasthenia gravis using single-cell manipulation tools.Thyroid Autoantibodies Display both “Original Antigenic Sin” and Epitope Spreading.Antigen-specific apheresis of autoantibodies in myasthenia gravis.

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P2860

Main Immunogenic Region Structure Promotes Binding of Conformation-Dependent Myasthenia Gravis Autoantibodies, Nicotinic Acetylcholine Receptor Conformation Maturation, and Agonist Sensitivity

http://www.wikidata.org/entity/Q27658065

description

2009 nî lūn-bûn

@nan

2009 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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2009 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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name

Main Immunogenic Region Struct ...... ation, and Agonist Sensitivity

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Main Immunogenic Region Struct ...... ation, and Agonist Sensitivity

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Main Immunogenic Region Struct ...... ation, and Agonist Sensitivity

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Main Immunogenic Region Struct ...... ation, and Agonist Sensitivity

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Main Immunogenic Region Struct ...... ation, and Agonist Sensitivity

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Main Immunogenic Region Struct ...... ation, and Agonist Sensitivity

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Main Immunogenic Region Struct ...... ation, and Agonist Sensitivity

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Main Immunogenic Region Struct ...... ation, and Agonist Sensitivity

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Main Immunogenic Region Struct ...... ation, and Agonist Sensitivity

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JNEUROSCI.2833-09.2009

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Journal of Neuroscience

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Main immunogenic region struct ...... ation, and agonist sensitivity

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G Diane Shelton

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Jie Luo

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Jon Lindstrom

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Marc H de Baets

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Palmer Taylor

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P2860

The crystal structure of the Fab fragment of a rat monoclonal antibody against the main immunogenic region of the human muscle acetylcholine receptor

Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors

Crystal structure of the extracellular domain of nAChR alpha1 bound to alpha-bungarotoxin at 1.94 A resolution

Mutation causing autosomal dominant nocturnal frontal lobe epilepsy alters Ca2+ permeability, conductance, and gating of human alpha4beta2 nicotinic acetylcholine receptors

Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations

alpha 5 Subunit alters desensitization, pharmacology, Ca++ permeability and Ca++ modulation of human neuronal alpha 3 nicotinic receptors

Refined structure of the nicotinic acetylcholine receptor at 4A resolution

Structure and function in rhodopsin: high-level expression of rhodopsin with restricted and homogeneous N-glycosylation by a tetracycline-inducible N-acetylglucosaminyltransferase I-negative HEK293S stable mammalian cell line

Isolation of potent human Fab fragments against a novel highly immunogenic region on human muscle acetylcholine receptor which protect the receptor from myasthenic autoantibodies.

Acetylcholine receptors and myasthenia.

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scholarly article

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10.1523/JNEUROSCI.2833-09.2009

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19890000

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myasthenia gravis

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