X-ray Crystallographic Analysis of α-Ketoheterocycle Inhibitors Bound to a Humanized Variant of Fatty Acid Amide Hydrolase - Wikidata - awgldk - TriplyDB

X-ray Crystallographic Analysis of α-Ketoheterocycle Inhibitors Bound to a Humanized Variant of Fatty Acid Amide Hydrolase

X-ray Crystallographic Analysis of α-Ketoheterocycle Inhibitors Bound to a Humanized Variant of Fatty Acid Amide Hydrolase

http://www.wikidata.org/entity/Q27658264

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Fluoride-Mediated Capture of a Noncovalent Bound State of a Reversible Covalent Enzyme Inhibitor: X-ray Crystallographic Analysis of an Exceptionally Potent α-Ketoheterocycle Inhibitor of Fatty Acid Amide Hydrolase Reversible Competitive α-Ketoheterocycle Inhibitors of Fatty Acid Amide Hydrolase Containing Additional Conformational Constraints in the Acyl Side Chain: Orally Active, Long-Acting Analgesics Discovery and molecular basis of potent noncovalent inhibitors of fatty acid amide hydrolase (FAAH)Rational Design of Fatty Acid Amide Hydrolase Inhibitors That Act by Covalently Bonding to Two Active Site Residues Latest advances in the discovery of fatty acid amide hydrolase inhibitors Keys to Lipid Selection in Fatty Acid Amide Hydrolase Catalysis: Structural Flexibility, Gating Residues and Multiple Binding Pockets Approximating protein flexibility through dynamic pharmacophore models: application to fatty acid amide hydrolase (FAAH)α-Ketoheterocycle inhibitors of fatty acid amide hydrolase: exploration of conformational constraints in the acyl side chain.The discovery and development of inhibitors of fatty acid amide hydrolase (FAAH).Discovery libraries targeting the major enzyme classes: the serine hydrolases.Sulfonyl fluoride inhibitors of fatty acid amide hydrolase.α-Ketoheterocycle-based Inhibitors of Fatty Acid Amide Hydrolase (FAAH).Drug design for neuropathic pain regulation from traditional Chinese medicine Design, synthesis, and characterization of α-ketoheterocycles that additionally target the cytosolic port Cys269 of fatty acid amide hydrolase Fatty acid amide signaling molecules.Recent advances in the discovery and evaluation of fatty acid amide hydrolase inhibitors.Cyclobutanone Analogues of β-Lactam Antibiotics: β-Lactamase Inhibitors with Untapped Potential?The Molecular Basis for Dual Fatty Acid Amide Hydrolase (FAAH)/Cyclooxygenase (COX) Inhibition.Biphenyl-3-yl alkylcarbamates as fatty acid amide hydrolase (FAAH) inhibitors: steric effects of N-alkyl chain on rat plasma and liver stability The Difference a Single Atom Can Make: Synthesis and Design at the Chemistry-Biology Interface.Asymmetric Synthesis of Gonytolide A: Strategic Use of an Aryl Halide Blocking Group for Oxidative Coupling.ω-Imidazolyl- and ω-Tetrazolylalkylcarbamates as Inhibitors of Fatty Acid Amide Hydrolase: Biological Activity and in vitro Metabolic Stability.

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P2860

X-ray Crystallographic Analysis of α-Ketoheterocycle Inhibitors Bound to a Humanized Variant of Fatty Acid Amide Hydrolase

http://www.wikidata.org/entity/Q27658264

description

2010 nî lūn-bûn

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2010 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2010 թվականի հունվարին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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X-ray Crystallographic Analysi ...... of Fatty Acid Amide Hydrolase

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X-ray Crystallographic Analysi ...... of Fatty Acid Amide Hydrolase

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X-ray Crystallographic Analysi ...... of Fatty Acid Amide Hydrolase

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X-ray Crystallographic Analysi ...... of Fatty Acid Amide Hydrolase

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X-ray Crystallographic Analysi ...... of Fatty Acid Amide Hydrolase

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X-ray Crystallographic Analysi ...... of Fatty Acid Amide Hydrolase

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X-ray Crystallographic Analysi ...... of Fatty Acid Amide Hydrolase

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X-ray Crystallographic Analysi ...... of Fatty Acid Amide Hydrolase

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Journal of Medicinal Chemistry

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X-ray Crystallographic Analysi ...... of Fatty Acid Amide Hydrolase

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P2093

Cyrine Ezzili

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Dale L Boger

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F Scott Kimball

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Joie Garfunkle

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Mauro Mileni

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Raymond C Stevens

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P2860

Molecular characterization of human and mouse fatty acid amide hydrolases

Mechanism of carbamate inactivation of FAAH: implications for the design of covalent inhibitors and in vivo functional probes for enzymes

Structural adaptations in a membrane enzyme that terminates endocannabinoid signaling

Structure-guided inhibitor design for human FAAH by interspecies active site conversion

Discovery and Characterization of a Highly Selective FAAH Inhibitor that Reduces Inflammatory Pain

Binding and Inactivation Mechanism of a Humanized Fatty Acid Amide Hydrolase by α-Ketoheterocycle Inhibitors Revealed from Cocrystal Structures

Fatty acid amide hydrolase competitively degrades bioactive amides and esters through a nonconventional catalytic mechanism

Fatty acid amide hydrolase inhibitors. Surprising selectivity of chiral azetidine ureas

A FAAH-regulated class of N-acyl taurines that activates TRP ion channels

Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity

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230-40

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scholarly article

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10.1021/JM9012196

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1

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53

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Benjamin Cravatt III

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2010-01-14T00:00:00Z

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38112541

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19924997

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2804032

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