The discovery and development of inhibitors of fatty acid amide hydrolase (FAAH).
about
Chemical probes of endocannabinoid metabolismA Binding Site for Nonsteroidal Anti-inflammatory Drugs in Fatty Acid Amide HydrolaseRational Design of Fatty Acid Amide Hydrolase Inhibitors That Act by Covalently Bonding to Two Active Site ResiduesFatty acid amide hydrolase inhibitors: a patent review (2009-2014)α-Ketoheterocycle inhibitors of fatty acid amide hydrolase: exploration of conformational constraints in the acyl side chain.Discovery libraries targeting the major enzyme classes: the serine hydrolases.Inhibition of FAAH, TRPV1, and COX2 by NSAID-serotonin conjugates.Development of fragment-based n-FABS NMR screening applied to the membrane enzyme FAAH.Novel associations between FAAH genetic variants and postoperative central opioid-related adverse effects.α-Ketoheterocycle-based Inhibitors of Fatty Acid Amide Hydrolase (FAAH).Piperidinyl thiazole isoxazolines: A new series of highly potent, slowly reversible FAAH inhibitors with analgesic propertiesN-Methylimidazole-catalyzed synthesis of carbamates from hydroxamic acids via the Lossen rearrangementA Double Whammy: Targeting Both Fatty Acid Amide Hydrolase (FAAH) and Cyclooxygenase (COX) To Treat Pain and Inflammation.Synthesis and Preliminary PET Imaging Studies of a FAAH Radiotracer ([¹¹C]MPPO) Based on α-Ketoheterocyclic Scaffold.FAAH inhibitor OL-135 disrupts contextual, but not auditory, fear conditioning in rats.Evaluation of NHS carbamates as a potent and selective class of endocannabinoid hydrolase inhibitorsDesign, synthesis, and characterization of α-ketoheterocycles that additionally target the cytosolic port Cys269 of fatty acid amide hydrolaseInvestigational drugs under development for the treatment of PTSD.What failed BIA 10-2474 Phase I clinical trial? Global speculations and recommendations for future Phase I trials.Fluorine NMR-based screening on cell membrane extracts.Discovery of MK-3168: A PET Tracer for Imaging Brain Fatty Acid Amide Hydrolase.Identification and characterization of carprofen as a multitarget fatty acid amide hydrolase/cyclooxygenase inhibitorO-hydroxyacetamide carbamates as a highly potent and selective class of endocannabinoid hydrolase inhibitors.Quantum mechanics/molecular mechanics modeling of fatty acid amide hydrolase reactivation distinguishes substrate from irreversible covalent inhibitors.O-(triazolyl)methyl carbamates as a novel and potent class of fatty acid amide hydrolase (FAAH) inhibitors.Fatty acid amide hydrolase-morphine interaction influences ventilatory response to hypercapnia and postoperative opioid outcomes in children.The Difference a Single Atom Can Make: Synthesis and Design at the Chemistry-Biology Interface.Design of Benzoxathiazin-3-one 1,1-Dioxides as a New Class of Irreversible Serine Hydrolase Inhibitors: Discovery of a Uniquely Selective PNPLA4 Inhibitor.What failed BIA 10–2474 Phase I clinical trial? Global speculations and recommendations for future Phase I trials.Design and Potency of Dual Soluble Epoxide Hydrolase/Fatty Acid Amide Hydrolase InhibitorsHarnessing the pyrroloquinoxaline scaffold for FAAH and MAGL interaction: definition of the structural determinants for enzyme inhibition
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P2860
The discovery and development of inhibitors of fatty acid amide hydrolase (FAAH).
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
The discovery and development of inhibitors of fatty acid amide hydrolase (FAAH).
@ast
The discovery and development of inhibitors of fatty acid amide hydrolase (FAAH).
@en
The discovery and development of inhibitors of fatty acid amide hydrolase
@nl
type
label
The discovery and development of inhibitors of fatty acid amide hydrolase (FAAH).
@ast
The discovery and development of inhibitors of fatty acid amide hydrolase (FAAH).
@en
The discovery and development of inhibitors of fatty acid amide hydrolase
@nl
prefLabel
The discovery and development of inhibitors of fatty acid amide hydrolase (FAAH).
@ast
The discovery and development of inhibitors of fatty acid amide hydrolase (FAAH).
@en
The discovery and development of inhibitors of fatty acid amide hydrolase
@nl
P2093
P2860
P1476
The discovery and development of inhibitors of fatty acid amide hydrolase (FAAH).
@en
P2093
Cyrine Ezzili
Dale L Boger
Katerina Otrubova
P2860
P304
P356
10.1016/J.BMCL.2011.06.096
P407
P577
2011-06-28T00:00:00Z