The amino-terminal disease hotspot of ryanodine receptors forms a cytoplasmic vestibule
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In cardiomyocytes, binding of unzipping peptide activates ryanodine receptor 2 and reciprocally inhibits calmodulin bindingElectron Microscopy: From 2D to 3D Images with Special Reference to MuscleSingle-Particle Cryo-EM of the Ryanodine Receptor Channel in an Aqueous EnvironmentSingle-particle cryo-EM of calcium release channels: structural validationStructural determination of the phosphorylation domain of the ryanodine receptorApo and InsP3-bound crystal structures of the ligand-binding domain of an InsP3 receptorDisease mutations in the ryanodine receptor N-terminal region couple to a mobile intersubunit interfaceStructural and functional conservation of key domains in InsP3 and ryanodine receptorsCombined approaches to flexible fitting and assessment in virus capsids undergoing conformational changeStructural Basis for Gating and Activation of RyR1.Divergent Activity Profiles of Type 1 Ryanodine Receptor Channels Carrying Malignant Hyperthermia and Central Core Disease Mutations in the Amino-Terminal RegionCardiac ryanodine receptors control heart rate and rhythmicity in adult miceInherited dysfunction of sarcoplasmic reticulum Ca2+ handling and arrhythmogenesisOutcome of the first electron microscopy validation task force meetingNumerical geometry of map and model assessment.Refinement of atomic models in high resolution EM reconstructions using Flex-EM and local assessment.Structural insights into the human RyR2 N-terminal region involved in cardiac arrhythmiasStructure of the rabbit ryanodine receptor RyR1 at near-atomic resolution.TEMPy: a Python library for assessment of three-dimensional electron microscopy density fitsValidation methods for low-resolution fitting of atomic structures to electron microscopy dataFRET-based localization of fluorescent protein insertions within the ryanodine receptor type 1.Short-coupled polymorphic ventricular tachycardia at rest linked to a novel ryanodine receptor (RyR2) mutation: leaky RyR2 channels under non-stress conditions.The excitation-contraction coupling mechanism in skeletal muscle.Structural mapping of divergent regions in the type 1 ryanodine receptor using fluorescence resonance energy transfer.Crystal structure and activating effect on RyRs of AhV_TL-I, a glycosylated thrombin-like enzyme from Agkistrodon halys snake venom.Structure of a mammalian ryanodine receptor.FRET-based trilateration of probes bound within functional ryanodine receptors.Functional and biochemical properties of ryanodine receptor type 1 channels from heterozygous R163C malignant hyperthermia-susceptible mice.Localization of the dantrolene-binding sequence near the FK506-binding protein-binding site in the three-dimensional structure of the ryanodine receptor.Malignant hyperthermia and the clinical significance of type-1 ryanodine receptor gene (RYR1) variants: proceedings of the 2013 MHAUS Scientific Conference.Generation and characterization of a mouse model harboring the exon-3 deletion in the cardiac ryanodine receptor.Single-particle cryo-EM of the ryanodine receptor channel in an aqueous environment.Regulation of ryanodine receptor RyR2 by protein-protein interactions: prediction of a PKA binding site on the N-terminal domain of RyR2 and its relation to disease causing mutationsThe H29D Mutation Does Not Enhance Cytosolic Ca2+ Activation of the Cardiac Ryanodine ReceptorMice expressing T4826I-RYR1 are viable but exhibit sex- and genotype-dependent susceptibility to malignant hyperthermia and muscle damageCrystal structures of ryanodine receptor SPRY1 and tandem-repeat domains reveal a critical FKBP12 binding determinant.Abnormal termination of Ca2+ release is a common defect of RyR2 mutations associated with cardiomyopathiesDantrolene rescues arrhythmogenic RYR2 defect in a patient-specific stem cell model of catecholaminergic polymorphic ventricular tachycardia.Increased Energy Demand during Adrenergic Receptor Stimulation Contributes to Ca(2+) Wave Generation.Cryo-electron microscopy and X-ray crystallography: complementary approaches to structural biology and drug discovery.
P2860
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P2860
The amino-terminal disease hotspot of ryanodine receptors forms a cytoplasmic vestibule
description
2010 nî lūn-bûn
@nan
2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
The amino-terminal disease hotspot of ryanodine receptors forms a cytoplasmic vestibule
@ast
The amino-terminal disease hotspot of ryanodine receptors forms a cytoplasmic vestibule
@en
The amino-terminal disease hotspot of ryanodine receptors forms a cytoplasmic vestibule
@nl
type
label
The amino-terminal disease hotspot of ryanodine receptors forms a cytoplasmic vestibule
@ast
The amino-terminal disease hotspot of ryanodine receptors forms a cytoplasmic vestibule
@en
The amino-terminal disease hotspot of ryanodine receptors forms a cytoplasmic vestibule
@nl
prefLabel
The amino-terminal disease hotspot of ryanodine receptors forms a cytoplasmic vestibule
@ast
The amino-terminal disease hotspot of ryanodine receptors forms a cytoplasmic vestibule
@en
The amino-terminal disease hotspot of ryanodine receptors forms a cytoplasmic vestibule
@nl
P2093
P356
P1433
P1476
The amino-terminal disease hotspot of ryanodine receptors forms a cytoplasmic vestibule
@en
P2093
Ching-Chieh Tung
Filip Van Petegem
Lynn Kimlicka
Paolo A Lobo
P2888
P356
10.1038/NATURE09471
P407
P577
2010-11-25T00:00:00Z
P6179
1032337905