A Structural Study of Norovirus 3C Protease Specificity: Binding of a Designed Active Site-Directed Peptide Inhibitor - Wikidata - awgldk - TriplyDB

A Structural Study of Norovirus 3C Protease Specificity: Binding of a Designed Active Site-Directed Peptide Inhibitor

A Structural Study of Norovirus 3C Protease Specificity: Binding of a Designed Active Site-Directed Peptide Inhibitor

http://www.wikidata.org/entity/Q27666173

about

Broad-spectrum antivirals against 3C or 3C-like proteases of picornaviruses, noroviruses, and coronaviruses.Structural and dynamics characterization of norovirus protease Structural Basis of Substrate Specificity and Protease Inhibition in Norwalk Virus Structure of a Murine Norovirus NS6 Protease-Product Complex Revealed by Adventitious Crystallisation Oxadiazole-Based Cell Permeable Macrocyclic Transition State Inhibitors of Norovirus 3CL Protease Antiviral targets of human noroviruses Structure-based exploration and exploitation of the S4 subsite of norovirus 3CL protease in the design of potent and permeable inhibitors.Characterization and inhibition of norovirus proteases of genogroups I and II using a fluorescence resonance energy transfer assay.The p4-p2' amino acids surrounding human norovirus polyprotein cleavage sites define the core sequence regulating self-processing order.Design, synthesis, and evaluation of inhibitors of Norwalk virus 3C protease.Structure-guided design and optimization of dipeptidyl inhibitors of norovirus 3CL protease. Structure-activity relationships and biochemical, X-ray crystallographic, cell-based, and in vivo studies Potent inhibition of norovirus 3CL protease by peptidyl α-ketoamides and α-ketoheterocycles.Potent inhibition of norovirus by dipeptidyl α-hydroxyphosphonate transition state mimics.Current tools for norovirus drug discovery Anti-norovirus therapeutics: a patent review (2010-2015).Macrocyclic inhibitors of 3C and 3C-like proteases of picornavirus, norovirus, and coronavirus.Recent Advances in the Discovery of Norovirus Therapeutics.A Cell-based Fluorescence Resonance Energy Transfer (FRET) Sensor Reveals Inter- and Intragenogroup Variations in Norovirus Protease Activity and Polyprotein Cleavage.Therapeutics and Immunoprophylaxis Against Noroviruses and Rotaviruses: The Past, Present, and Future.Design, synthesis, and evaluation of a novel series of macrocyclic inhibitors of norovirus 3CL protease.Structure-based design and synthesis of triazole-based macrocyclic inhibitors of norovirus protease: Structural, biochemical, spectroscopic, and antiviral studies.Structure determination of Murine Norovirus NS6 proteases with C-terminal extensions designed to probe protease-substrate interactions.Inhibition of norovirus 3CL protease by bisulfite adducts of transition state inhibitors Structural and inhibitor studies of norovirus 3C-like proteases.Structure-based design and functional studies of novel noroviral 3C protease chimaeras offer insights into substrate specificity.Structure-guided design, synthesis and evaluation of oxazolidinone-based inhibitors of norovirus 3CL protease.Selection and Characterization of Rupintrivir-Resistant Norwalk Virus Replicon Cells In Vitro.In silico screening for human norovirus antivirals reveals a novel non-nucleoside inhibitor of the viral polymerase.

P2860

Q27671667-CDDD49C2-4525-47BA-A531-AA8B544C2CD8 Q27675897-2FB6EB2C-A204-4CB9-AE81-8C59CC098D1C Q27676085-DF4C9611-C066-46E0-8C9F-2C3807C9C6F5 Q27681097-5C0382EC-1F92-4584-857F-B615D4E34B16 Q27703748-CF049A72-141C-46AE-986C-6AD436AC0717 Q30249527-5B275E25-5E3E-4A89-8CCC-86BEFAA4CDB2 Q33883350-34FD1A12-7DC1-4869-893F-4CB2263AA80B Q34112325-F2B68090-78EA-448A-ADEA-CA912F574A75 Q34262232-371C00C8-AF95-482C-837F-334EFFD89FD6 Q35175461-CB0F1937-9604-4924-93A6-F5471CA3F05C Q35792986-578AD149-4A17-4FBD-948E-9802749A0732 Q36074548-30AFDEB8-57A8-44E7-ACD8-53E472C361D4 Q37028683-A1CBFB52-2BBC-49F8-9CA9-BEDCADF31E6E Q37062340-73F55933-581C-402E-80D8-58F182C3B34E Q37101808-95A6AC89-D044-4135-92AE-A19F410B7D0E Q37114506-7F30A78D-371C-4320-86DE-3EACE64F4EF4 Q37517465-51E6422B-34B8-46E4-BF89-1DD09B5F1CA8 Q38835886-35BFF7D8-E40A-4828-A94B-F2263866C6CE Q40044140-A2CD7447-894C-4D5B-903E-DA3A09DC3B10 Q40390221-DEC8B33B-3F50-4295-9144-10AA0E6D20E3 Q40655363-17E97F9F-752A-4D44-B1F5-3C12D52CDA79 Q41257306-6194A90B-F6B7-4E38-AE6F-23C836143914 Q41681368-C52AB70D-3E65-424B-B643-878238F9A9CA Q41767053-0AD411A5-C3CE-4CA5-B0F0-36B17F5979F6 Q42155699-87F2E364-FA32-4B18-A6F2-F571B93404BC Q47308003-DDAE2028-1C44-46C7-9962-87391251C901 Q52659751-7F4531C5-A487-4F7B-8CC6-5D9FCC7BFEE3 Q52668531-7AB95B13-7B2B-4D8A-A143-74FBB21CAD69

P2860

A Structural Study of Norovirus 3C Protease Specificity: Binding of a Designed Active Site-Directed Peptide Inhibitor

http://www.wikidata.org/entity/Q27666173

description

2011 nî lūn-bûn

@nan

2011 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի հունվարին հրատարակված գիտական հոդված

@hy

2011年の論文

@ja

2011年論文

@yue

2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

name

A Structural Study of Noroviru ...... ite-Directed Peptide Inhibitor

@ast

A Structural Study of Noroviru ...... ite-Directed Peptide Inhibitor

@en

A Structural Study of Noroviru ...... ite-Directed Peptide Inhibitor

@nl

type

label

A Structural Study of Noroviru ...... ite-Directed Peptide Inhibitor

@ast

A Structural Study of Noroviru ...... ite-Directed Peptide Inhibitor

@en

A Structural Study of Noroviru ...... ite-Directed Peptide Inhibitor

@nl

prefLabel

A Structural Study of Noroviru ...... ite-Directed Peptide Inhibitor

@ast

A Structural Study of Noroviru ...... ite-Directed Peptide Inhibitor

@en

A Structural Study of Noroviru ...... ite-Directed Peptide Inhibitor

@nl

P1433

Q27666173-D0282035-6512-434C-A197-31288744D6C9

P1476

Q27666173-471198C2-BC96-47FB-8A40-499217E2BBAC

P2093

Q27666173-21CBD432-134F-413A-A58C-C43213631131

Q27666173-5A59A375-9AB4-49B4-B729-C9E184EE24BD

Q27666173-6AA730D1-FE8E-4EE8-9560-4FFFF77F8C53

Q27666173-70248EC9-2AB4-49C4-95C7-28637982148C

Q27666173-70AD7ABB-A975-4469-8386-F92785CB1BD9

Q27666173-7ED33D91-7445-4E4E-B746-FC3A48BC60BC

Q27666173-AFDA1900-6DB2-4BDA-ABD6-8B63921D2C86

Q27666173-B85859AD-74BA-4C0C-BA18-605A67E2A30C

Q27666173-F03CCC3E-BC06-457F-9BFB-AABB13AEBF5A

Q27666173-F1013D79-A2E1-4FC5-BF8C-C9265ACA72D3

P2860

Q27666173-0BC8C554-0D2B-4CB2-97F4-E821A7784EB6

Q27666173-14936996-AB4D-4A9C-8F45-7A0452933E81

Q27666173-202E20BA-BFB8-48B0-956B-2D1CC2D7B5A6

Q27666173-26F14CEA-A3F7-4EF8-AD3A-60B065B8FCFD

Q27666173-2AC0B873-62E1-4E64-A60E-036C0B36FF54

Q27666173-33528FFC-4D1D-4A8E-8752-E3788BD714C4

Q27666173-34C514FC-30ED-4C6B-AD1A-86751C862BD9

Q27666173-3F9DAACE-8C7A-406A-9F8D-F87A54AF54C6

Q27666173-6A394C90-B3C3-400E-B14F-DC6BD0057B1E

Q27666173-6A3ADDAE-9075-40E4-B76D-888104D9F5C6

P304

Q27666173-7B670EBF-DDAE-4047-8AE0-CEFCBD804348

P31

Q27666173-0894CE26-E414-48BA-BE8C-5407E75670EB

P356

Q27666173-6B8CDC5E-51B7-4CDE-81FE-22886D3E8C3E

P407

Q27666173-1DF63C73-C870-4B3A-982F-7A04508BE430

P433

Q27666173-58258F32-84DF-4B45-BE15-38444773EC43

P478

Q27666173-33D94190-A244-4391-AF4F-73B698A0BC5D

P50

Q27666173-140DB3D5-72D5-466C-B6D3-E67917CF897B

Q27666173-2BA0F9C3-4FCA-45BB-8DC8-7F44DB561C26

P577

Q27666173-852EBDC7-8D20-483D-9769-B0EFCD00A2B3

P5875

Q27666173-F2B0F272-820B-43B8-B6EA-FB53B0655461

P698

Q27666173-FE8FB3DB-F9FF-4618-8997-9559739705DF

P921

Q27666173-06A4C4D6-C94A-4D43-970B-1414811AA065

P932

Q27666173-6AFE322A-CA11-4982-89D3-84AEEB3924B9

P356

P1433

P1476

A Structural Study of Noroviru ...... ite-Directed Peptide Inhibitor

@en

P2093

Ed Mitchell

http://www.w3.org/2001/XMLSchema#string

Jonathan B Cooper

http://www.w3.org/2001/XMLSchema#string

Paul R Lambden

http://www.w3.org/2001/XMLSchema#string

Peter M Shoolingin-Jordan

http://www.w3.org/2001/XMLSchema#string

Peter T Erskine

http://www.w3.org/2001/XMLSchema#string

Raj S Gill

http://www.w3.org/2001/XMLSchema#string

Robert Broadbridge

http://www.w3.org/2001/XMLSchema#string

Robert J Hussey

http://www.w3.org/2001/XMLSchema#string

Shu-Fen Coker

http://www.w3.org/2001/XMLSchema#string

Steve Wood

http://www.w3.org/2001/XMLSchema#string

P2860

MolProbity: all-atom structure validation for macromolecular crystallography

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

Structure-assisted design of mechanism-based irreversible inhibitors of human rhinovirus 3C protease with potent antiviral activity against multiple rhinovirus serotypes

Crystal structure of an inhibitor complex of the 3C proteinase from hepatitis A virus (HAV) and implications for the polyprotein processing in HAV

The refined crystal structure of the 3C gene product from hepatitis A virus: specific proteinase activity and RNA recognition

Refined X-ray crystallographic structure of the poliovirus 3C gene product

On the size of the active site in proteases. I. Papain

SHELXL: high-resolution refinement

The CCP4 suite: programs for protein crystallography

Scaling and assessment of data quality

P304

240-9

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1021/BI1008497

http://www.w3.org/2001/XMLSchema#string

P407

P433

2

http://www.w3.org/2001/XMLSchema#string

P478

50

http://www.w3.org/2001/XMLSchema#string

P50

Leighton Coates

P577

2011-01-18T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

49655537

http://www.w3.org/2001/XMLSchema#string

P698

21128685

http://www.w3.org/2001/XMLSchema#string

P921

P932

3058531

http://www.w3.org/2001/XMLSchema#string