The refined crystal structure of the 3C gene product from hepatitis A virus: specific proteinase activity and RNA recognition
about
ATP hydrolysis in Eg5 kinesin involves a catalytic two-water mechanismRoles of the Picornaviral 3C Proteinase in the Viral Life Cycle and Host CellsMultiple enzymatic activities associated with recombinant NS3 protein of hepatitis C virusDisruption of innate immunity due to mitochondrial targeting of a picornaviral protease precursorStructure of coronavirus main proteinase reveals combination of a chymotrypsin fold with an extra alpha-helical domain.A Structural Study of Norovirus 3C Protease Specificity: Binding of a Designed Active Site-Directed Peptide InhibitorCrystal Structures of Enterovirus 71 3C Protease Complexed with Rupintrivir Reveal the Roles of Catalytically Important ResiduesBroad-spectrum antivirals against 3C or 3C-like proteases of picornaviruses, noroviruses, and coronaviruses.Structural Basis for Antiviral Inhibition of the Main Protease, 3C, from Human Enterovirus 933C Protease of Enterovirus 68: Structure-Based Design of Michael Acceptor Inhibitors and Their Broad-Spectrum Antiviral Effects against PicornavirusesInteraction between polypeptide 3ABC and the 5'-terminal structural elements of the genome of Aichi virus: implication for negative-strand RNA synthesisStructural basis for host membrane remodeling induced by protein 2B of hepatitis A virusFunctional binding of hexanucleotides to 3C protease of hepatitis A virus.Characterization of a torovirus main proteinaseGenome variability and capsid structural constraints of hepatitis a virus.Detecting coevolution in and among protein domainsStructural aspects of activation pathways of aspartic protease zymogens and viral 3C protease precursorsHepatitis A virus capsid protein VP1 has a heterogeneous C terminus.Deletion mapping of the encephalomyocarditis virus primary cleavage site.Disruption of TLR3 signaling due to cleavage of TRIF by the hepatitis A virus protease-polymerase processing intermediate, 3CD.Hepatitis A virus 3C protease cleaves NEMO to impair induction of beta interferonA norovirus protease structure provides insights into active and substrate binding site integrityReplication of subgenomic hepatitis A virus RNAs expressing firefly luciferase is enhanced by mutations associated with adaptation of virus to growth in cultured cellsIdentification of active-site amino acid residues in the Chiba virus 3C-like proteaseUtilization of a mammalian cell-based RNA binding assay to characterize the RNA binding properties of picornavirus 3C proteinases.X-ray crystallographic structure of the Norwalk virus protease at 1.5-A resolution.Calicivirus 3C-like proteinase inhibits cellular translation by cleavage of poly(A)-binding protein.The protein structures that shape caspase activity, specificity, activation and inhibition.Viral precursor protein P3 and its processed products perform discrete and essential functions in the poliovirus RNA replication complex.Hepatitis A virus (HAV) packaging size limitPicornavirus genome replication. Identification of the surface of the poliovirus (PV) 3C dimer that interacts with PV 3Dpol during VPg uridylylation and construction of a structural model for the PV 3C2-3Dpol complexThe 3C-like proteinase of an invertebrate nidovirus links coronavirus and potyvirus homologs.Glutamyl Endopeptidases: The Puzzle of Substrate SpecificityRole of RNA structure and RNA binding activity of foot-and-mouth disease virus 3C protein in VPg uridylylation and virus replicationProcessing of proteinase precursors and their effect on hepatitis A virus particle formation.Improving proteolytic cleavage at the 3A/3B site of the hepatitis A virus polyprotein impairs processing and particle formation, and the impairment can be complemented in trans by 3AB and 3ABC.Hepatitis A virus proteinase 3C binding to viral RNA: correlation with substrate binding and enzyme dimerization.Characterization of an alphamesonivirus 3C-like protease defines a special group of nidovirus main proteases.Structure-based design and functional studies of novel noroviral 3C protease chimaeras offer insights into substrate specificity.Structural and mutagenic analysis of foot-and-mouth disease virus 3C protease reveals the role of the beta-ribbon in proteolysis.
P2860
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P2860
The refined crystal structure of the 3C gene product from hepatitis A virus: specific proteinase activity and RNA recognition
description
1997 nî lūn-bûn
@nan
1997 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի մարտին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
The refined crystal structure ...... e activity and RNA recognition
@ast
The refined crystal structure ...... e activity and RNA recognition
@en
The refined crystal structure ...... e activity and RNA recognition
@nl
type
label
The refined crystal structure ...... e activity and RNA recognition
@ast
The refined crystal structure ...... e activity and RNA recognition
@en
The refined crystal structure ...... e activity and RNA recognition
@nl
prefLabel
The refined crystal structure ...... e activity and RNA recognition
@ast
The refined crystal structure ...... e activity and RNA recognition
@en
The refined crystal structure ...... e activity and RNA recognition
@nl
P2093
P2860
P1433
P1476
The refined crystal structure ...... e activity and RNA recognition
@en
P2093
B A Malcolm
E M Bergmann
M M Chernaia
S C Mosimann
P2860
P304
P577
1997-03-01T00:00:00Z