Broad-spectrum antivirals against 3C or 3C-like proteases of picornaviruses, noroviruses, and coronaviruses.
about
Structural and dynamics characterization of norovirus proteaseStructural Basis of Substrate Specificity and Protease Inhibition in Norwalk VirusX-ray structure and inhibition of the feline infectious peritonitis virus 3C-like protease: Structural implications for drug designOxadiazole-Based Cell Permeable Macrocyclic Transition State Inhibitors of Norovirus 3CL ProteaseAntiviral targets of human norovirusesNonnucleoside inhibitors of norovirus RNA polymerase: scaffolds for rational drug design.Structure-based exploration and exploitation of the S4 subsite of norovirus 3CL protease in the design of potent and permeable inhibitors.Development of a Gaussia luciferase-based human norovirus protease reporter system: cell type-specific profile of Norwalk virus protease precursors and evaluation of inhibitors.The p4-p2' amino acids surrounding human norovirus polyprotein cleavage sites define the core sequence regulating self-processing order.Crystallization and preliminary crystallographic study of Porcine epidemic diarrhea virus main protease in complex with an inhibitorBroad-spectrum inhibitors against 3C-like proteases of feline coronaviruses and feline caliciviruses.Repurposing of rutin for the inhibition of norovirus replication.Molecular chaperone Hsp90 is a therapeutic target for norovirusesStructure-guided design and optimization of dipeptidyl inhibitors of norovirus 3CL protease. Structure-activity relationships and biochemical, X-ray crystallographic, cell-based, and in vivo studiesReversal of the Progression of Fatal Coronavirus Infection in Cats by a Broad-Spectrum Coronavirus Protease Inhibitor.PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C protease to enhance interferon signaling and control viral infectionPotent inhibition of enterovirus D68 and human rhinoviruses by dipeptidyl aldehydes and α-ketoamides.Potent inhibition of feline coronaviruses with peptidyl compounds targeting coronavirus 3C-like proteaseTreatment of norovirus infections: moving antivirals from the bench to the bedside.X-Ray Structure and Inhibition of 3C-like Protease from Porcine Epidemic Diarrhea Virus.Potent inhibition of norovirus by dipeptidyl α-hydroxyphosphonate transition state mimics.Current tools for norovirus drug discoveryAnti-norovirus therapeutics: a patent review (2010-2015).Macrocyclic inhibitors of 3C and 3C-like proteases of picornavirus, norovirus, and coronavirus.Design, synthesis, and bioevaluation of viral 3C and 3C-like protease inhibitors.Recent Advances in the Discovery of Norovirus Therapeutics.Progress towards the prevention and treatment of norovirus infections.Global quantitative proteomic analysis of human glioma cells profiled host protein expression in response to enterovirus type 71 infection.Broad-spectrum antiviral agents.Glutamyl Endopeptidases: The Puzzle of Substrate SpecificityThe enterovirus protease inhibitor rupintrivir exerts cross-genotypic anti-norovirus activity and clears cells from the norovirus replicon.Efficacy of a 3C-like protease inhibitor in treating various forms of acquired feline infectious peritonitis.Therapeutics and Immunoprophylaxis Against Noroviruses and Rotaviruses: The Past, Present, and Future.Development of a luciferase-based biosensor to assess enterovirus 71 3C protease activity in living cells.Design, synthesis, and evaluation of a novel series of macrocyclic inhibitors of norovirus 3CL protease.Structure-based design and synthesis of triazole-based macrocyclic inhibitors of norovirus protease: Structural, biochemical, spectroscopic, and antiviral studies.Structure determination of Murine Norovirus NS6 proteases with C-terminal extensions designed to probe protease-substrate interactions.Inhibition of norovirus 3CL protease by bisulfite adducts of transition state inhibitorsStructural and inhibitor studies of norovirus 3C-like proteases.Structure-guided design, synthesis and evaluation of oxazolidinone-based inhibitors of norovirus 3CL protease.
P2860
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P2860
Broad-spectrum antivirals against 3C or 3C-like proteases of picornaviruses, noroviruses, and coronaviruses.
description
2012 nî lūn-bûn
@nan
2012 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Broad-Spectrum Antivirals agai ...... Noroviruses, and Coronaviruses
@nl
Broad-spectrum antivirals agai ...... oroviruses, and coronaviruses.
@ast
Broad-spectrum antivirals agai ...... oroviruses, and coronaviruses.
@en
type
label
Broad-Spectrum Antivirals agai ...... Noroviruses, and Coronaviruses
@nl
Broad-spectrum antivirals agai ...... oroviruses, and coronaviruses.
@ast
Broad-spectrum antivirals agai ...... oroviruses, and coronaviruses.
@en
prefLabel
Broad-Spectrum Antivirals agai ...... Noroviruses, and Coronaviruses
@nl
Broad-spectrum antivirals agai ...... oroviruses, and coronaviruses.
@ast
Broad-spectrum antivirals agai ...... oroviruses, and coronaviruses.
@en
P2093
P2860
P3181
P356
P1433
P1476
Broad-spectrum antivirals agai ...... noroviruses, and coronaviruses
@en
P2093
Kevin R Alliston
Kok-Chuan Tiew
Kyeong-Ok Chang
Scott Lovell
Sivakoteswara Rao Mandadapu
William C Groutas
P2860
P304
11754-11762
P3181
P356
10.1128/JVI.01348-12
P577
2012-08-22T00:00:00Z