The Mre11:Rad50 Structure Shows an ATP-Dependent Molecular Clamp in DNA Double-Strand Break Repair
about
Human single-stranded DNA binding proteins are essential for maintaining genomic stabilityStructural Insights into Ring Formation of Cohesin and Related Smc ComplexesMechanisms and regulation of mitotic recombination in Saccharomyces cerevisiaeThe Mre11/Rad50/Nbs1 complex: recent insights into catalytic activities and ATP-driven conformational changesATP driven structural changes of the bacterial Mre11:Rad50 catalytic head complexMre11 ATLD17/18 mutation retains Tel1/ATM activity but blocks DNA double-strand break repairStructural and functional insights into DNA-end processing by the archaeal HerA helicase-NurA nuclease complexStructure and mechanism of the UvrA-UvrB DNA damage sensorThe ABC-F protein EttA gates ribosome entry into the translation elongation cycleStructure of Mre11–Nbs1 complex yields insights into ataxia-telangiectasia–like disease mutations and DNA damage signalingATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signalingStructural basis for DNA recognition and nuclease processing by the Mre11 homologue SbcD in double-strand breaks repairEnd-resection at DNA double-strand breaks in the three domains of lifeDNA end recognition by the Mre11 nuclease dimer: insights into resection and repair of damaged DNA.Envisioning the dynamics and flexibility of Mre11-Rad50-Nbs1 complex to decipher its roles in DNA replication and repairEfficient 5'-3' DNA end resection by HerA and NurA is essential for cell viability in the crenarchaeon Sulfolobus islandicusTel1 and Rif2 Regulate MRX Functions in End-Tethering and Repair of DNA Double-Strand BreaksRare key functional domain missense substitutions in MRE11A, RAD50, and NBN contribute to breast cancer susceptibility: results from a Breast Cancer Family Registry case-control mutation-screening studyProtein-Protein Interactions Mediated by Helical Tertiary Structure Motifs.End resection at double-strand breaks: mechanism and regulation.Multifunctional role of ATM/Tel1 kinase in genome stability: from the DNA damage response to telomere maintenanceAutoinhibition of bacteriophage T4 Mre11 by its C-terminal domain.Recruitment kinetics of DNA repair proteins Mdc1 and Rad52 but not 53BP1 depend on damage complexity.DNA repair: Making the cut.The Ctf18RFC clamp loader is essential for telomere stability in telomerase-negative and mre11 mutant alleles.ATM alters the otherwise robust chromatin mobility at sites of DNA double-strand breaks (DSBs) in human cells.Mimivirus reveals Mre11/Rad50 fusion proteins with a sporadic distribution in eukaryotes, bacteria, viruses and plasmidsMukBEF, a chromosomal organizer.Mre11-Rad50 complex crystals suggest molecular calisthenics.The Rad50 coiled-coil domain is indispensable for Mre11 complex functionsDNA repair factor MRE11/RAD50 cleaves 3'-phosphotyrosyl bonds and resects DNA to repair damage caused by topoisomerase 1 poisons.ATP hydrolysis by RAD50 protein switches MRE11 enzyme from endonuclease to exonuclease.Interdependence of the rad50 hook and globular domain functionsFunctional Analysis of the Bacteriophage T4 Rad50 Homolog (gp46) Coiled-coil DomainDisruption of the bacteriophage T4 Mre11 dimer interface reveals a two-state mechanism for exonuclease activityATP-dependent DNA binding, unwinding, and resection by the Mre11/Rad50 complexNutrient deprivation regulates DNA damage repair in cardiomyocytes via loss of the base-excision repair enzyme OGG1.Processing of DNA double-stranded breaks and intermediates of recombination and repair by Saccharomyces cerevisiae Mre11 and its stimulation by Rad50, Xrs2, and Sae2 proteins.Ataxia telangiectasia-mutated (ATM) kinase activity is regulated by ATP-driven conformational changes in the Mre11/Rad50/Nbs1 (MRN) complex.Mechanism and regulation of DNA end resection in eukaryotes
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P2860
The Mre11:Rad50 Structure Shows an ATP-Dependent Molecular Clamp in DNA Double-Strand Break Repair
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2011 nî lūn-bûn
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2011 թուականի Ապրիլին հրատարակուած գիտական յօդուած
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2011 թվականի ապրիլին հրատարակված գիտական հոդված
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2011年の論文
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2011年論文
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2011年論文
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2011年論文
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2011年論文
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2011年論文
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2011年论文
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The Mre11:Rad50 Structure Show ...... DNA Double-Strand Break Repair
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The Mre11:Rad50 Structure Show ...... DNA Double-Strand Break Repair
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The Mre11:Rad50 Structure Show ...... DNA Double-Strand Break Repair
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The Mre11:Rad50 Structure Show ...... DNA Double-Strand Break Repair
@ast
The Mre11:Rad50 Structure Show ...... DNA Double-Strand Break Repair
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The Mre11:Rad50 Structure Show ...... DNA Double-Strand Break Repair
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The Mre11:Rad50 Structure Show ...... DNA Double-Strand Break Repair
@ast
The Mre11:Rad50 Structure Show ...... DNA Double-Strand Break Repair
@en
The Mre11:Rad50 Structure Show ...... DNA Double-Strand Break Repair
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P2093
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P50
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The Mre11:Rad50 Structure Show ...... DNA Double-Strand Break Repair
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P2093
Christian B Schiller
Christof Angermüller
Derk J Bemeleit
Emanuel Clausing
Sophia Hartung
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P3181
P356
10.1016/J.CELL.2011.02.038
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P50
P577
2011-04-01T00:00:00Z