Inhibition of Apoptosis and NF-κB Activation by Vaccinia Protein N1 Occur via Distinct Binding Surfaces and Make Different Contributions to Virulence
about
Orthopoxvirus genes that mediate disease virulence and host tropismPhosphatidylserine receptors: enhancers of enveloped virus entry and infectionStructural basis of Deerpox virus-mediated inhibition of apoptosisVaccinia virus protein A49 is an unexpected member of the B-cell Lymphoma (Bcl)-2 protein familyThe N Terminus of the Vaccinia Virus Protein F1L Is an Intrinsically Unstructured Region That Is Not Involved in Apoptosis Regulation.Innate immune response of human plasmacytoid dendritic cells to poxvirus infection is subverted by vaccinia E3 via its Z-DNA/RNA binding domainPoxvirus targeting of E3 ligase β-TrCP by molecular mimicry: a mechanism to inhibit NF-κB activation and promote immune evasion and virulence.NFκB activation by modified vaccinia virus as a novel strategy to enhance neutrophil migration and HIV-specific T-cell responses.Enhancement of CD8(+) T-cell memory by removal of a vaccinia virus nuclear factor-κB inhibitor.Inhibition of Translation Initiation by Protein 169: A Vaccinia Virus Strategy to Suppress Innate and Adaptive Immunity and Alter Virus Virulence.Vaccinia Virus Protein C6 Inhibits Type I IFN Signalling in the Nucleus and Binds to the Transactivation Domain of STAT2Sheeppox virus SPPV14 encodes a Bcl-2-like cell death inhibitor that counters a distinct set of mammalian proapoptotic proteins.Attenuation of monkeypox virus by deletion of genomic regionsVaccinia virus protein C4 inhibits NF-κB activation and promotes virus virulence.Vaccinia virus protein K7 is a virulence factor that alters the acute immune response to infectionVaccinia virus protein N2 is a nuclear IRF3 inhibitor that promotes virulenceIncreased attenuation but decreased immunogenicity by deletion of multiple vaccinia virus immunomodulators.Poxviral protein A52 stimulates p38 mitogen-activated protein kinase (MAPK) activation by causing tumor necrosis factor receptor-associated factor 6 (TRAF6) self-association leading to transforming growth factor β-activated kinase 1 (TAK1) recruitmeStructural biology of the Bcl-2 family and its mimicry by viral proteinsDeletion of the vaccinia virus N2L gene encoding an inhibitor of IRF3 improves the immunogenicity of modified vaccinia virus Ankara expressing HIV-1 antigens.Ectromelia virus encodes a BTB/kelch protein, EVM150, that inhibits NF-κB signaling.The Bcl-2 family: structures, interactions and targets for drug discovery.Vaccinia virus inhibits NF-κB-dependent gene expression downstream of p65 translocation.Analysis of the anti-apoptotic activity of four vaccinia virus proteins demonstrates that B13 is the most potent inhibitor in isolation and during viral infectionVaccinia virus virulence factor N1 can be ubiquitylated on multiple lysine residues.Molecular network, pathway, and functional analysis of time-dependent gene changes associated with pancreatic cancer susceptibility to oncolytic vaccinia virotherapy.Poxviruses Utilize Multiple Strategies to Inhibit Apoptosis.The Bcl-2 Family in Host-Virus Interactions.Vaccinia virus protein A49 activates Wnt signalling by targetting the E3 ligase β-TrCP.Modulating Vaccinia Virus Immunomodulators to Improve Immunological Memory.The Gene of Goatpox Virus Encodes an Inhibitor of NF-κB and Apoptosis and May Serve as an Improved Insertion Site To Generate Vectored Live Vaccine
P2860
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P2860
Inhibition of Apoptosis and NF-κB Activation by Vaccinia Protein N1 Occur via Distinct Binding Surfaces and Make Different Contributions to Virulence
description
2011 nî lūn-bûn
@nan
2011 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Inhibition of Apoptosis and NF ...... ent Contributions to Virulence
@ast
Inhibition of Apoptosis and NF ...... ent Contributions to Virulence
@en
Inhibition of Apoptosis and NF ...... ent Contributions to Virulence
@nl
type
label
Inhibition of Apoptosis and NF ...... ent Contributions to Virulence
@ast
Inhibition of Apoptosis and NF ...... ent Contributions to Virulence
@en
Inhibition of Apoptosis and NF ...... ent Contributions to Virulence
@nl
altLabel
Inhibition of apoptosis and NF ...... ent contributions to virulence
@en
prefLabel
Inhibition of Apoptosis and NF ...... ent Contributions to Virulence
@ast
Inhibition of Apoptosis and NF ...... ent Contributions to Virulence
@en
Inhibition of Apoptosis and NF ...... ent Contributions to Virulence
@nl
P2093
P2860
P50
P921
P3181
P1433
P1476
Inhibition of apoptosis and NF ...... ent contributions to virulence
@en
P2093
Geoffrey L Smith
Hongwei Ren
Jonathan M Grimes
Kieran McGourty
Samantha Cooray
P2860
P304
P3181
P356
10.1371/JOURNAL.PPAT.1002430
P407
P577
2011-12-15T00:00:00Z