Structural basis for the killing of human beta cells by CD8(+) T cells in type 1 diabetes.
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Beta cell antigens in type 1 diabetes: triggers in pathogenesis and therapeutic targetsThe Extended Family of CD1d-Restricted NKT Cells: Sifting through a Mixed Bag of TCRs, Antigens, and FunctionsMore tricks with tetramers: a practical guide to staining T cells with peptide-MHC multimersMinimal conformational plasticity enables TCR cross-reactivity to different MHC class II heterodimersPeptide length determines the outcome of TCR/peptide-MHCI engagementThe Energetic Basis Underpinning T-cell Receptor Recognition of a Super-bulged Peptide Bound to a Major Histocompatibility Complex Class I MoleculeT-cell Receptor Specificity Maintained by Altered ThermodynamicsIncreased peptide contacts govern high affinity binding of a modified TCR whilst maintaining a native pMHC docking modeCrossreactivity of a human autoimmune TCR is dominated by a single TCR loopEffect of CDR3 Sequences and Distal V Gene Residues in Regulating TCR-MHC Contacts and Ligand SpecificityT-cell receptor recognition of HLA-DQ2-gliadin complexes associated with celiac diseaseT cell receptor reversed polarity recognition of a self-antigen major histocompatibility complexImmunological biomarkers: catalysts for translational advances in autoimmune diabetesStructural Analysis of Der p 1-Antibody Complexes and Comparison with Complexes of Proteins or Peptides with Monoclonal AntibodiesHow structural adaptability exists alongside HLA-A2 bias in the human αβ TCR repertoireUsing X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens.Comparison of peptide-major histocompatibility complex tetramers and dextramers for the identification of antigen-specific T cells.Antibody stabilization of peptide-MHC multimers reveals functional T cells bearing extremely low-affinity TCRsCD8(+) T cell cross-reactivity profiles and HIV-1 immune escape towards an HLA-B35-restricted immunodominant Nef epitope.The first step of peptide selection in antigen presentation by MHC class I molecules.Structure of Staphylococcal Enterotoxin E in Complex with TCR Defines the Role of TCR Loop Positioning in Superantigen Recognition.T cells in the control of organ-specific autoimmunityInsulitis and characterisation of infiltrating T cells in surgical pancreatic tail resections from patients at onset of type 1 diabetes.Distortion of the Major Histocompatibility Complex Class I Binding Groove to Accommodate an Insulin-derived 10-Mer PeptideEtiopathogenesis of insulin autoimmunity.β-cell-specific CD8 T cell phenotype in type 1 diabetes reflects chronic autoantigen exposure.The potential of Fas ligand (apoptosis-inducing molecule) as an unconventional therapeutic target in type 1 diabetes.HLA-B7-restricted islet epitopes are differentially recognized in type 1 diabetic children and adults and form weak peptide-HLA complexes.Autoreactive T cells bypass negative selection and respond to self-antigen stimulation during infection.Human β-cell killing by autoreactive preproinsulin-specific CD8 T cells is predominantly granule-mediated with the potency dependent upon T-cell receptor avidity.Direct molecular mimicry enables off-target cardiovascular toxicity by an enhanced affinity TCR designed for cancer immunotherapy.Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity.Immune-mediated β-cell death in type 1 diabetes: lessons from human β-cell linesPathogenic mechanisms in type 1 diabetes: the islet is both target and driver of disease.Autoimmunity against INS-IGF2 protein expressed in human pancreatic islets.Human CD8(+) T cells transduced with an additional receptor bispecific for both Mycobacterium tuberculosis and HIV-1 recognize both epitopes.Targeted suppression of autoreactive CD8(+) T-cell activation using blocking anti-CD8 antibodies.The versatility of the αβ T-cell antigen receptor.Proinsulin Expression Shapes the TCR Repertoire but Fails to Control the Development of Low-Avidity Insulin-Reactive CD8+ T Cells.The dual roles of inflammatory cytokines and chemokines in the regulation of autoimmune diseases and their clinical implications.
P2860
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P2860
Structural basis for the killing of human beta cells by CD8(+) T cells in type 1 diabetes.
description
2012 nî lūn-bûn
@nan
2012 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Structural basis for the killi ...... +) T cells in type 1 diabetes.
@ast
Structural basis for the killi ...... +) T cells in type 1 diabetes.
@en
Structural basis for the killing of human beta cells by CD8+ T cells in type 1 diabetes
@nl
type
label
Structural basis for the killi ...... +) T cells in type 1 diabetes.
@ast
Structural basis for the killi ...... +) T cells in type 1 diabetes.
@en
Structural basis for the killing of human beta cells by CD8+ T cells in type 1 diabetes
@nl
prefLabel
Structural basis for the killi ...... +) T cells in type 1 diabetes.
@ast
Structural basis for the killi ...... +) T cells in type 1 diabetes.
@en
Structural basis for the killing of human beta cells by CD8+ T cells in type 1 diabetes
@nl
P2093
P2860
P50
P3181
P356
P1433
P1476
Structural basis for the killi ...... +) T cells in type 1 diabetes.
@en
P2093
Ania Skowera
Anna Fuller
Anna M Bulek
Bent K Jakobsen
David A Price
Emma Gostick
Florian Madura
Garry Dolton
Guo C Huang
Jan W Drijfhout
P2860
P304
P3181
P356
10.1038/NI.2206
P407
P577
2012-01-15T00:00:00Z