about
Correlation of in situ mechanosensitive responses of the Moraxella catarrhalis adhesin UspA1 with fibronectin and receptor CEACAM1 binding.Functional and biophysical characterization of an HLA-A*6801-restricted HIV-specific T cell receptorThe multiple roles of the CD8 coreceptor in T cell biology: opportunities for the selective modulation of self-reactive cytotoxic T cellsThe promise of γδ T cells and the γδ T cell receptor for cancer immunotherapyMore tricks with tetramers: a practical guide to staining T cells with peptide-MHC multimersComputational design and crystal structure of an enhanced affinity mutant human CD8 alphaalpha coreceptorGerm Line-governed Recognition of a Cancer Epitope by an Immunodominant Human T-cell ReceptorGenetic and Structural Basis for Selection of a Ubiquitous T Cell Receptor Deployed in Epstein-Barr Virus InfectionT-cell Receptor-optimized Peptide Skewing of the T-cell Repertoire Can Enhance Antigen TargetingPeptide length determines the outcome of TCR/peptide-MHCI engagementStructural basis for the killing of human beta cells by CD8(+) T cells in type 1 diabetes.T-cell Receptor (TCR)-Peptide Specificity Overrides Affinity-enhancing TCR-Major Histocompatibility Complex InteractionsMolecular Basis of a Dominant T Cell Response to an HIV Reverse Transcriptase 8-mer Epitope Presented by the Protective Allele HLA-B*51:01Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens.Modification of MHC anchor residues generates heteroclitic peptides that alter TCR binding and T cell recognitionComparison of peptide-major histocompatibility complex tetramers and dextramers for the identification of antigen-specific T cells.Real time detection of peptide-MHC dissociation reveals that improvement of primary MHC-binding residues can have a minimal, or no, effect on stability.Human TCR-binding affinity is governed by MHC class restriction.Antibody stabilization of peptide-MHC multimers reveals functional T cells bearing extremely low-affinity TCRsAnti-CD8 antibodies can trigger CD8+ T cell effector function in the absence of TCR engagement and improve peptide-MHCI tetramer staining.A molecular switch in immunodominant HIV-1-specific CD8 T-cell epitopes shapes differential HLA-restricted escape.Distortion of the Major Histocompatibility Complex Class I Binding Groove to Accommodate an Insulin-derived 10-Mer PeptideT-cell libraries allow simple parallel generation of multiple peptide-specific human T-cell clones.Naive CD8⁺ T-cell precursors display structured TCR repertoires and composite antigen-driven selection dynamicsCD8: adhesion molecule, co-receptor and immuno-modulator.Differential clade-specific HLA-B*3501 association with HIV-1 disease outcome is linked to immunogenicity of a single Gag epitope.The impact of HLA class I and EBV latency-II antigen-specific CD8(+) T cells on the pathogenesis of EBV(+) Hodgkin lymphomaHuman β-cell killing by autoreactive preproinsulin-specific CD8 T cells is predominantly granule-mediated with the potency dependent upon T-cell receptor avidity.Direct molecular mimicry enables off-target cardiovascular toxicity by an enhanced affinity TCR designed for cancer immunotherapy.Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity.Cellular-level versus receptor-level response threshold hierarchies in T-cell activation.Paediatric non-progression following grandmother-to-child HIV transmissionDetection of low avidity CD8(+) T cell populations with coreceptor-enhanced peptide-major histocompatibility complex class I tetramers.Tricks with tetramers: how to get the most from multimeric peptide-MHC.The versatility of the αβ T-cell antigen receptor.Structural and biophysical determinants of αβ T-cell antigen recognition.The molecular determinants of CD8 co-receptor function.Re-Directing CD4(+) T Cell Responses with the Flanking Residues of MHC Class II-Bound Peptides: The Core is Not Enough.Engineering and functional evaluation of a single-chain antibody against HIV-1 external glycoprotein gp120.The T cell antigen receptor: the Swiss army knife of the immune system.
P50
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P50
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hulumtues
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հետազոտող
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David K. Cole
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David K. Cole
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David K. Cole
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David K. Cole
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David K. Cole
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David K. Cole
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David K. Cole
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David K. Cole
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David K. Cole
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David K. Cole
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P2798
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0000-0003-0028-9396