Small Molecule Regulation of Protein Conformation by Binding in the Flap of HIV Protease
about
Charting a Path to Success in Virtual ScreeningCrystallographic Fragment-Based Drug Discovery: Use of a Brominated Fragment Library Targeting HIV ProteaseParameterization of an effective potential for protein-ligand binding from host-guest affinity data.Docking and Linking of Fragments To Discover Jumonji Histone Demethylase Inhibitors.Discovery of HIV Type 1 Aspartic Protease Hit Compounds through Combined Computational Approaches.Identifying binding hot spots on protein surfaces by mixed-solvent molecular dynamics: HIV-1 protease as a test caseEnzyme Tunnels and Gates As Relevant Targets in Drug Design.Switches of hydrogen bonds during ligand-protein association processes determine binding kinetics.Reply to Varma: Elucidation of the signal origin for label-free, free-solution interactions"Old Dogs with New Tricks": exploiting alternative mechanisms of action and new drug design strategies for clinically validated HIV targets.Fragment-based approaches to anti-HIV drug discovery: state of the art and future opportunities.Virtual screening with AutoDock Vina and the common pharmacophore engine of a low diversity library of fragments and hits against the three allosteric sites of HIV integrase: participation in the SAMPL4 protein-ligand binding challengeDistinguishing binders from false positives by free energy calculations: fragment screening against the flap site of HIV proteaseAn experimental check of backscattering interferometry.
P2860
Q26779035-EC414892-62F0-440E-AD2A-2F279D66DCA4Q27679849-F190D6C4-200A-443E-BD35-07868A709A20Q30986053-80407092-45C1-42C2-930C-09A74B334778Q35877411-120389E2-A98F-4A0F-BFDC-9656037D105AQ36076431-FBF59099-5BBA-4001-BADE-D0A42BECD18FQ36218072-879E8875-EFFF-4220-8B03-BCC3E91964ABQ36221405-2F358554-4B2F-4465-9A1C-FCB914A5EBCFQ36640463-14AEC04F-835D-411A-959F-F854D45FE658Q37213705-F4403B5C-FCC5-4B6D-919D-4661709126ABQ38212854-E59F7344-E405-41F1-8059-1D666793B679Q38587368-CDAE7CAD-2023-437A-A682-490AE2E35E78Q40578605-8E43C12D-E2E3-40DF-B102-70B5D5461A0CQ41989179-DB1BEBDF-3396-425D-B42C-10D16B2BCAECQ50989534-F59F155F-D2B9-4229-AFF0-C288935AFF65
P2860
Small Molecule Regulation of Protein Conformation by Binding in the Flap of HIV Protease
description
2013 nî lūn-bûn
@nan
2013 թուականին հրատարակուած գիտական յօդուած
@hyw
2013 թվականին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Small Molecule Regulation of Protein Conformation by Binding in the Flap of HIV Protease
@ast
Small Molecule Regulation of Protein Conformation by Binding in the Flap of HIV Protease
@en
Small Molecule Regulation of Protein Conformation by Binding in the Flap of HIV Protease
@nl
type
label
Small Molecule Regulation of Protein Conformation by Binding in the Flap of HIV Protease
@ast
Small Molecule Regulation of Protein Conformation by Binding in the Flap of HIV Protease
@en
Small Molecule Regulation of Protein Conformation by Binding in the Flap of HIV Protease
@nl
prefLabel
Small Molecule Regulation of Protein Conformation by Binding in the Flap of HIV Protease
@ast
Small Molecule Regulation of Protein Conformation by Binding in the Flap of HIV Protease
@en
Small Molecule Regulation of Protein Conformation by Binding in the Flap of HIV Protease
@nl
P2093
P2860
P356
P1433
P1476
Small Molecule Regulation of Protein Conformation by Binding in the Flap of HIV Protease
@en
P2093
Alexander L Perryman
Arthur J Olson
Bruce E Torbett
C David Stout
Jin-Kyu Rhee
John H Elder
Max W Chang
Meaghan Happer
Michael M Baksh
Stefano Forli
P2860
P304
P356
10.1021/CB300611P
P50
P577
2013-01-01T00:00:00Z