Multimode, Cooperative Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors - Wikidata - awgldk - TriplyDB

Multimode, Cooperative Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors

Multimode, Cooperative Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors

http://www.wikidata.org/entity/Q27678141

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Interaction of the HIV-1 intasome with transportin 3 protein (TNPO3 or TRN-SR2)Blind prediction of HIV integrase binding from the SAMPL4 challenge Distribution and Redistribution of HIV-1 Nucleocapsid Protein in Immature, Mature, and Integrase-Inhibited Virions: a Role for Integrase in Maturation Allosteric Inhibition of Human Immunodeficiency Virus Integrase Small Molecule Inhibitors of the LEDGF Site of Human Immunodeficiency Virus Integrase Identified by Fragment Screening and Structure Based Design Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturation The A128T Resistance Mutation Reveals Aberrant Protein Multimerization as the Primary Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors New Class of HIV-1 Integrase (IN) Inhibitors with a Dual Mode of Action Dual inhibition of HIV-1 replication by integrase-LEDGF allosteric inhibitors is predominant at the post-integration stage.A new class of multimerization selective inhibitors of HIV-1 integrase Discovery of BI 224436, a Noncatalytic Site Integrase Inhibitor (NCINI) of HIV-1 Multiple cellular proteins interact with LEDGF/p75 through a conserved unstructured consensus motif A New Class of Allosteric HIV-1 Integrase Inhibitors Identified by Crystallographic Fragment Screening of the Catalytic Core Domain Retroviral Integrase: Then and Now Non-catalytic site HIV-1 integrase inhibitors disrupt core maturation and induce a reverse transcription block in target cells Retroviral DNA Integration Abasic phosphorothioate oligomers inhibit HIV-1 reverse transcription and block virus transmission across polarized ectocervical organ cultures.HIV virions as nanoscopic test tubes for probing oligomerization of the integrase enzyme.HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor.Molecular modeling study on the allosteric inhibition mechanism of HIV-1 integrase by LEDGF/p75 binding site inhibitors.Preclinical profile of BI 224436, a novel HIV-1 non-catalytic-site integrase inhibitor A critical role of the C-terminal segment for allosteric inhibitor-induced aberrant multimerization of HIV-1 integrase.Molecular mechanisms of retroviral integration site selection.The mechanism of H171T resistance reveals the importance of Nδ-protonated His171 for the binding of allosteric inhibitor BI-D to HIV-1 integrase.Retroviral integrase proteins and HIV-1 DNA integration HIV-1 IN/Pol recruits LEDGF/p75 into viral particles The allosteric HIV-1 integrase inhibitor BI-D affects virion maturation but does not influence packaging of a functional RNA genome Alternative modulation of protein-protein interactions by small molecules Kuwanon-L as a New Allosteric HIV-1 Integrase Inhibitor: Molecular Modeling and Biological Evaluation.Development and Identification of a Novel Anti-HIV-1 Peptide Derived by Modification of the N-Terminal Domain of HIV-1 Integrase.The molecular biology of HIV integrase.Methods for the Analyses of Inhibitor-Induced Aberrant Multimerization of HIV-1 Integrase.Integrating the HIV-1 assembly/maturation pathway.Allosteric inhibition of HIV-1 integrase activity.The Competitive Interplay between Allosteric HIV-1 Integrase Inhibitor BI/D and LEDGF/p75 during the Early Stage of HIV-1 Replication Adversely Affects Inhibitor Potency.LEDGIN-mediated Inhibition of Integrase-LEDGF/p75 Interaction Reduces Reactivation of Residual Latent HIV GalaxyRefineComplex: Refinement of protein-protein complex model structures driven by interface repacking.Exploiting drug-resistant enzymes as tools to identify thienopyrimidinone inhibitors of human immunodeficiency virus reverse transcriptase-associated ribonuclease H.Multimodal mechanism of action of allosteric HIV-1 integrase inhibitors.Computational and synthetic approaches for developing Lavendustin B derivatives as allosteric inhibitors of HIV-1 integrase

P2860

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Multimode, Cooperative Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors

http://www.wikidata.org/entity/Q27678141

description

2012 nî lūn-bûn

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2012 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2012 թվականի մայիսին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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Multimode, Cooperative Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors

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Multimode, Cooperative Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors

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Multimode, Cooperative Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors

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Multimode, Cooperative Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors

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Multimode, Cooperative Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors

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Multimode, Cooperative Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors

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Multimode, Cooperative Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors

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Multimode, Cooperative Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors

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Multimode, Cooperative Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors

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JBC.M112.354373

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Journal of Biological Chemistry

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Multimode, Cooperative Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors

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P2093

Alan Engelman

http://www.w3.org/2001/XMLSchema#string

Alison Slaughter

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Humeyra Taskent-Sezgin

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Jacques J Kessl

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James R Fuchs

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Lei Feng

http://www.w3.org/2001/XMLSchema#string

Li Wu

http://www.w3.org/2001/XMLSchema#string

Nivedita Jena

http://www.w3.org/2001/XMLSchema#string

Stuart F J Le Grice

http://www.w3.org/2001/XMLSchema#string

Suresh de Silva

http://www.w3.org/2001/XMLSchema#string

P2860

LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells

Retroviral intasome assembly and inhibition of DNA strand transfer

A tripartite DNA-binding element, comprised of the nuclear localization signal and two AT-hook motifs, mediates the association of LEDGF/p75 with chromatin in vivo

Identification of a small-molecule binding site at the dimer interface of the HIV integrase catalytic domain

A Novel Co-Crystal Structure Affords the Design of Gain-of-Function Lentiviral Integrase Mutants in the Presence of Modified PSIP1/LEDGF/p75

Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication

Crystal structure of the catalytic domain of HIV-1 integrase: similarity to other polynucleotidyl transferases

Solution structure of the N-terminal zinc binding domain of HIV-1 integrase

Optimal description of a protein structure in terms of multiple groups undergoing TLS motion

Phasercrystallographic software

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10.1074/JBC.M112.354373

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20

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287

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Mamuka Kvaratskhelia

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2012-05-11T00:00:00Z

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22437836

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allosteric inhibitor

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3351293

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