Dual inhibition of HIV-1 replication by integrase-LEDGF allosteric inhibitors is predominant at the post-integration stage.
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Distribution and Redistribution of HIV-1 Nucleocapsid Protein in Immature, Mature, and Integrase-Inhibited Virions: a Role for Integrase in MaturationAllosteric Inhibition of Human Immunodeficiency Virus IntegraseMultiple cellular proteins interact with LEDGF/p75 through a conserved unstructured consensus motifA New Class of Allosteric HIV-1 Integrase Inhibitors Identified by Crystallographic Fragment Screening of the Catalytic Core DomainStructural Basis for Inhibitor-Induced Aggregation of HIV IntegraseRetroviral DNA IntegrationA critical role of the C-terminal segment for allosteric inhibitor-induced aberrant multimerization of HIV-1 integrase.The mechanism of H171T resistance reveals the importance of Nδ-protonated His171 for the binding of allosteric inhibitor BI-D to HIV-1 integrase.HIV-1 IN/Pol recruits LEDGF/p75 into viral particlesThe allosteric HIV-1 integrase inhibitor BI-D affects virion maturation but does not influence packaging of a functional RNA genomeHIV-1 Gag as an Antiviral Target: Development of Assembly and Maturation Inhibitors.Host Factors in Retroviral Integration and the Selection of Integration Target Sites.Methods for the Analyses of Inhibitor-Induced Aberrant Multimerization of HIV-1 Integrase.The Competitive Interplay between Allosteric HIV-1 Integrase Inhibitor BI/D and LEDGF/p75 during the Early Stage of HIV-1 Replication Adversely Affects Inhibitor Potency.LEDGIN-mediated Inhibition of Integrase-LEDGF/p75 Interaction Reduces Reactivation of Residual Latent HIVQuantitative evaluation of the antiretroviral efficacy of dolutegravir.Computational and synthetic approaches for developing Lavendustin B derivatives as allosteric inhibitors of HIV-1 integraseLEDGINs, non-catalytic site inhibitors of HIV-1 integrase: a patent review (2006 - 2014).HIV-1 integrase multimerization as a therapeutic target.Natural Product Kuwanon-L Inhibits HIV-1 Replication through Multiple Target Binding.TALEN knockout of the PSIP1 gene in human cells: analyses of HIV-1 replication and allosteric integrase inhibitor mechanism.Different Pathways Leading to Integrase Inhibitors ResistanceAllosteric HIV-1 Integrase Inhibitors Lead to Premature Degradation of the Viral RNA Genome and Integrase in Target Cells.Dynamic Oligomerization of Integrase Orchestrates HIV Nuclear EntryHIV-1 Integrase Binds the Viral RNA Genome and Is Essential during Virion Morphogenesis.Indole-based allosteric inhibitors of HIV-1 integrasePyrazolo[1,5-a]pyrimidine-based macrocycles as novel HIV-1 inhibitors: a patent evaluation of WO2015123182.Resistance to pyridine-based inhibitor KF116 reveals an unexpected role of integrase in HIV-1 Gag-Pol proteolytic processing.Probing Resistance Mutations in Retroviral Integrases by Direct Measurement of Dolutegravir Fluorescence.The HIV-1 integrase-LEDGF allosteric inhibitor MUT-A: resistance profile, impairment of virus maturation and infectivity but without influence on RNA packaging or virus immunoreactivity.Cellular and molecular mechanisms of HIV-1 integration targeting.Structure-function analyses unravel distinct effects of allosteric inhibitors of HIV-1 integrase on viral maturation and integration.CLIP-related methodologies and their application to retrovirology.Nup153 Unlocks the Nuclear Pore Complex for HIV-1 Nuclear Translocation in Non-dividing CellsRecent advances in the discovery of small-molecule inhibitors of HIV-1 integrase
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P2860
Dual inhibition of HIV-1 replication by integrase-LEDGF allosteric inhibitors is predominant at the post-integration stage.
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2013 nî lūn-bûn
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2013 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2013年の論文
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2013年論文
@yue
2013年論文
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2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
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name
Dual inhibition of HIV-1 repli ...... at the post-integration stage
@nl
Dual inhibition of HIV-1 repli ...... at the post-integration stage.
@ast
Dual inhibition of HIV-1 repli ...... at the post-integration stage.
@en
type
label
Dual inhibition of HIV-1 repli ...... at the post-integration stage
@nl
Dual inhibition of HIV-1 repli ...... at the post-integration stage.
@ast
Dual inhibition of HIV-1 repli ...... at the post-integration stage.
@en
prefLabel
Dual inhibition of HIV-1 repli ...... at the post-integration stage
@nl
Dual inhibition of HIV-1 repli ...... at the post-integration stage.
@ast
Dual inhibition of HIV-1 repli ...... at the post-integration stage.
@en
P2093
P2860
P3181
P356
P1433
P1476
Dual inhibition of HIV-1 repli ...... at the post-integration stage.
@en
P2093
Benoit Ledoussal
Céline Amadori
Eric Deprez
Erwann Le Rouzic
Francis Chevreuil
François Moreau
Frédéric Le Strat
Jean-Michel Bruneau
Julie Brias
P2860
P2888
P3181
P356
10.1186/1742-4690-10-144
P577
2013-11-21T00:00:00Z
P5875
P6179
1040153847