about
Allosteric Inhibition of Human Immunodeficiency Virus IntegraseA new class of multimerization selective inhibitors of HIV-1 integraseMultiple cellular proteins interact with LEDGF/p75 through a conserved unstructured consensus motifRetroviral DNA IntegrationCritical appraisal of elvitegravir in the treatment of HIV-1/AIDS.Microbial Natural Product Alternariol 5-O-Methyl Ether Inhibits HIV-1 Integration by Blocking Nuclear Import of the Pre-Integration Complex.Preclinical profile of BI 224436, a novel HIV-1 non-catalytic-site integrase inhibitorVirtual screening of integrase inhibitors by large scale binding free energy calculations: the SAMPL4 challenge.A critical role of the C-terminal segment for allosteric inhibitor-induced aberrant multimerization of HIV-1 integrase.Small-molecule inhibitors of protein-protein interactions: progressing toward the reality.The mechanism of H171T resistance reveals the importance of Nδ-protonated His171 for the binding of allosteric inhibitor BI-D to HIV-1 integrase.The allosteric HIV-1 integrase inhibitor BI-D affects virion maturation but does not influence packaging of a functional RNA genomeUneven genetic robustness of HIV-1 integrase.Kuwanon-L as a New Allosteric HIV-1 Integrase Inhibitor: Molecular Modeling and Biological Evaluation.Host Factors in Retroviral Integration and the Selection of Integration Target Sites.Methods for the Analyses of Inhibitor-Induced Aberrant Multimerization of HIV-1 Integrase.GalaxyRefineComplex: Refinement of protein-protein complex model structures driven by interface repacking.An Essential Role of INI1/hSNF5 Chromatin Remodeling Protein in HIV-1 Posttranscriptional Events and Gag/Gag-Pol Stability.Critical Contribution of Tyr15 in the HIV-1 Integrase (IN) in Facilitating IN Assembly and Nonenzymatic Function through the IN Precursor Form with Reverse Transcriptase.Multimodal mechanism of action of allosteric HIV-1 integrase inhibitors.LEDGINs, non-catalytic site inhibitors of HIV-1 integrase: a patent review (2006 - 2014).Allosteric modulation of protein oligomerization: an emerging approach to drug design."Old Dogs with New Tricks": exploiting alternative mechanisms of action and new drug design strategies for clinically validated HIV targets.HIV-1 integrase multimerization as a therapeutic target.The preclinical discovery and development of dolutegravir for the treatment of HIV.HIV-Induced Epigenetic Alterations in Host Cells.Retroviral integrase protein and intasome nucleoprotein complex structures.Allosteric HIV-1 integrase inhibitors promote aberrant protein multimerization by directly mediating inter-subunit interactions: Structural and thermodynamic modeling studies.Blocking the interaction between HIV-1 integrase and human LEDGF/p75: mutational studies, virtual screening and molecular dynamics simulations.Investigational HIV integrase inhibitors in phase I and phase II clinical trials.Furospinosulin-1, Marine Spongean Furanosesterterpene, Suppresses the Growth of Hypoxia-Adapted Cancer Cells by Binding to Transcriptional Regulators p54(nrb) and LEDGF/p75.Quinolines from the cyclocondensation of isatoic anhydride with ethyl acetoacetate: preparation of ethyl 4-hydroxy-2-methylquinoline-3-carboxylate and derivativesSynthesis and Evaluation of Aryl Quinolines as HIV-1 Integrase Multimerization InhibitorsRecent advances in the discovery of small-molecule inhibitors of HIV-1 integrase
P2860
Q27644578-E4CFCF08-6AC0-4553-A6E6-995E6918A7F6Q27683994-66AFBAA5-E2CE-423F-B0D3-86369C725754Q27701733-CD5605E5-4D9A-4DAE-B84E-E95046A4398CQ28596842-3CA4CE85-FBF6-4B12-BA90-4A1518860C0FQ33680234-804D9501-CBA0-4D1A-BD94-64A4160DFACBQ33753929-65EC5843-FDAD-4B14-85BC-8D81014CB839Q33797858-6436F15B-8B2E-4363-BD7B-9562103EA694Q34065423-9E2BA46D-6C34-4CF2-8F30-19296F5C7D5AQ34249167-5A581462-7853-4AF8-8E58-65A6E3FBEBC5Q34263719-9AA072F5-4FE5-43B9-B5F0-84D5B2850CFEQ34611548-A3CCC388-98B6-46BB-B93F-07FD1B621347Q35215018-37E60A4E-7891-447F-86B6-2E9E5F12FFDFQ35360391-9B34BF4B-D595-448F-B28C-B93C5F41EB7CQ35770636-273E6FAE-C633-4D14-8E8C-ACCFCDF82C49Q35916677-205A7E88-56EA-4347-8001-C101A0C93624Q36691836-AAAA1DC1-5F3C-485B-BCAE-383A19C949AEQ37184982-75A6D19D-7DBD-45C3-A325-ED51BA228D8FQ37347358-2FD61625-7A1B-4672-AD6C-77078F2B0AA1Q37512925-A1A9911C-6F98-48BB-9B97-D8B76D09EFA8Q37574479-5C2ED69C-8433-4AE3-9ACB-61A7407436CEQ38199193-4DBAC5C1-0085-4BE1-8D33-7A7D30601510Q38208847-32E08B26-A270-48B1-8C2C-3D04E1B57F75Q38212854-A95EB495-0756-435A-A86E-6B81863FADD0Q38380688-5B45E568-EC43-4E81-9200-4AF62BE21842Q38620489-20BEEF97-9AE1-4FB8-98AC-3D9BB11C4FB5Q38667121-7C3A496F-9F33-4F4C-BB8A-7E1EB5C2B213Q39176798-2ED8A28C-1254-41D4-85EE-7AAF10FF9885Q40519415-DF2B322A-E5F3-4E0C-81DF-763900B4EED9Q42245267-6C5CFB97-AD59-4598-93D4-E9A71D6C76EDQ47909110-4150CDDE-CAC3-478C-80AE-80C9605BEF3DQ51574784-8047EC97-41D4-4045-8E43-EBF602896775Q57820947-CCD4A8F5-2ABF-4E30-B11E-530481AAFF20Q57822203-9B056C3D-B279-4EF8-B637-6A0291BC33A3Q58760446-F82E908A-FE19-4C61-893D-48C5F3D6200A
P2860
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Allosteric inhibition of HIV-1 integrase activity.
@en
type
label
Allosteric inhibition of HIV-1 integrase activity.
@en
prefLabel
Allosteric inhibition of HIV-1 integrase activity.
@en
P2860
P1476
Allosteric inhibition of HIV-1 integrase activity.
@en
P2093
Alan Engelman
Jacques J Kessl
P2860
P304
P356
10.1016/J.CBPA.2013.04.010
P577
2013-05-03T00:00:00Z