Novel Binding Mode of a Potent and Selective Tankyrase Inhibitor
about
Disruption of Wnt/β-Catenin Signaling and Telomeric Shortening Are Inextricable Consequences of Tankyrase Inhibition in Human CellsWnt/beta-catenin signaling and small molecule inhibitorsChemical Disruption of Wnt-dependent Cell Fate Decision-making Mechanisms in Cancer and Regenerative MedicineStructure-Based Design of 2-Aminopyridine Oxazolidinones as Potent and Selective Tankyrase InhibitorsFH535 Suppresses Osteosarcoma Growth In Vitro and Inhibits Wnt Signaling through TankyrasesScaffold hopping approach on the route to selective tankyrase inhibitors.Structural Implications for Selective Targeting of PARPs.PARP-1 mechanism for coupling DNA damage detection to poly(ADP-ribose) synthesis.PARP inhibitors in cancer therapy: an update.Structural biology of the writers, readers, and erasers in mono- and poly(ADP-ribose) mediated signaling.Tankyrases as drug targets.Tankyrases: structure, function and therapeutic implications in cancer.Recent advances in the structure-based rational design of TNKSIs.Clipping the Wings of Glioblastoma: Modulation of WNT as a Novel Therapeutic Strategy.Inhibition of tankyrases induces Axin stabilization and blocks Wnt signalling in breast cancer cells.Identifying Direct Protein Targets of Poly-ADP-Ribose Polymerases (PARPs) Using Engineered PARP Variants-Orthogonal Nicotinamide Adenine Dinucleotide (NAD+) Analog Pairs.Molecular insights on TNKS1/TNKS2 and inhibitor-IWR1 interactions.Regulation of Wnt/β-catenin signalling by tankyrase-dependent poly(ADP-ribosyl)ation and scaffolding.Discovery of new dual binding TNKS inhibitors of Wnt signaling inhibition by pharmacophore modeling, molecular docking and bioassay.
P2860
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P2860
Novel Binding Mode of a Potent and Selective Tankyrase Inhibitor
description
2012 nî lūn-bûn
@nan
2012 թուականին հրատարակուած գիտական յօդուած
@hyw
2012 թվականին հրատարակված գիտական հոդված
@hy
2012年の論文
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2012年論文
@yue
2012年論文
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2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
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name
Novel Binding Mode of a Potent and Selective Tankyrase Inhibitor
@ast
Novel Binding Mode of a Potent and Selective Tankyrase Inhibitor
@en
Novel Binding Mode of a Potent and Selective Tankyrase Inhibitor
@nl
type
label
Novel Binding Mode of a Potent and Selective Tankyrase Inhibitor
@ast
Novel Binding Mode of a Potent and Selective Tankyrase Inhibitor
@en
Novel Binding Mode of a Potent and Selective Tankyrase Inhibitor
@nl
altLabel
Novel binding mode of a potent and selective tankyrase inhibitor
@en
prefLabel
Novel Binding Mode of a Potent and Selective Tankyrase Inhibitor
@ast
Novel Binding Mode of a Potent and Selective Tankyrase Inhibitor
@en
Novel Binding Mode of a Potent and Selective Tankyrase Inhibitor
@nl
P2093
P2860
P1433
P1476
Novel Binding Mode of a Potent and Selective Tankyrase Inhibitor
@en
P2093
P2860
P304
P356
10.1371/JOURNAL.PONE.0033740
P407
P577
2012-01-01T00:00:00Z