Kinase regulation by hydrophobic spine assembly in cancer.
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Dynamics-Driven Allostery in Protein KinasesHydration effects on the efficacy of the Epidermal growth factor receptor kinase inhibitor afatinib.Exploring Molecular Mechanisms of Paradoxical Activation in the BRAF Kinase Dimers: Atomistic Simulations of Conformational Dynamics and Modeling of Allosteric Communication Networks and Signaling Pathways.Computational and Experimental Characterization of Patient Derived Mutations Reveal an Unusual Mode of Regulatory Spine Assembly and Drug Sensitivity in EGFR Kinase.Activation loop phosphorylation regulates B-Raf in vivo and transformation by B-Raf mutants.The yin-yang of kinase activation and unfolding explains the peculiarity of Val600 in the activation segment of BRAF.Integration of signaling in the kinome: Architecture and regulation of the αC Helix.Mutation of a kinase allosteric node uncouples dynamics linked to phosphotransfer.Ensemble-based modeling and rigidity decomposition of allosteric interaction networks and communication pathways in cyclin-dependent kinases: Differentiating kinase clients of the Hsp90-Cdc37 chaperone.Pockets as structural descriptors of EGFR kinase conformations.Development of the first model of a phosphorylated, ATP/Mg2+-containing B-Raf monomer by molecular dynamics simulations: a tool for structure-based design.Optimized Target Residence Time: Type I1/2 Inhibitors for p38α MAP Kinase with Improved Binding Kinetics through Direct Interaction with the R-Spine.MYC and RAF: Key Effectors in Cellular Signaling and Major Drivers in Human Cancer.Genetic code expansion and live cell imaging reveal that Thr308 phosphorylation is irreplaceable and sufficient for Akt1 activity.Small Molecules Targeting the Inactive Form of the Mnk1/2 Kinases.The dimer-dependent catalytic activity of RAF family kinases is revealed through characterizing their oncogenic mutants
P2860
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P2860
Kinase regulation by hydrophobic spine assembly in cancer.
description
2014 nî lūn-bûn
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2014年の論文
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2014年学术文章
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2014年学术文章
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2014年学术文章
@zh-cn
2014年学术文章
@zh-hans
2014年学术文章
@zh-my
2014年学术文章
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2014年學術文章
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2014年學術文章
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name
Kinase regulation by hydrophobic spine assembly in cancer.
@en
Kinase regulation by hydrophobic spine assembly in cancer.
@nl
type
label
Kinase regulation by hydrophobic spine assembly in cancer.
@en
Kinase regulation by hydrophobic spine assembly in cancer.
@nl
prefLabel
Kinase regulation by hydrophobic spine assembly in cancer.
@en
Kinase regulation by hydrophobic spine assembly in cancer.
@nl
P2093
P2860
P356
P1476
Kinase regulation by hydrophobic spine assembly in cancer
@en
P2093
Andrey S Shaw
Hiruy S Meharena
Lalima G Ahuja
Natarajan Kannan
Susan S Taylor
P2860
P304
P356
10.1128/MCB.00943-14
P407
P577
2014-10-27T00:00:00Z