Structurally encoded intraclass differences in EphA clusters drive distinct cell responses
about
Eph-ephrin signaling in nervous system developmentEphrin-A3 promotes and maintains slow muscle fiber identity during postnatal development and reinnervation.EPHB4 kinase-inactivating mutations cause autosomal dominant lymphatic-related hydrops fetalis.Protein kinase A can block EphA2 receptor-mediated cell repulsion by increasing EphA2 S897 phosphorylationStructural basis of latrophilin-FLRT interactionDimerization of Tie2 mediated by its membrane-proximal FNIII domains.Collagen induces activation of DDR1 through lateral dimer association and phosphorylation between dimersPromiscuous and specific recognition among ephrins and Eph receptorsPhase transitions of multivalent proteins can promote clustering of membrane receptorsOligomerization and nanocluster organization render specificity.Development and structural analysis of a nanomolar cyclic peptide antagonist for the EphA4 receptorDistinctive Structure of the EphA3/Ephrin-A5 Complex Reveals a Dual Mode of Eph Receptor Interaction for Ephrin-A5.GTP-Dependent K-Ras DimerizationSuper-complexes of adhesion GPCRs and neural guidance receptors.EphA4 has distinct functionality from EphA7 in the corticothalamic system during mouse brain development.The composition of EphB2 clusters determines the strength in the cellular repulsion response.Structures of the EphA2 Receptor at the Membrane: Role of Lipid Interactions.Regulation of signaling interactions and receptor endocytosis in growing blood vessels.Attractive and repulsive factors act through multi-subunit receptor complexes to regulate nerve fiber growth.A role of the SAM domain in EphA2 receptor activation.Inverse Expression Levels of EphrinA3 and EphrinA5 Contribute to Dopaminergic Differentiation of Human SH-SY5Y Cells.Glycoengineering of EphA4 Fc leads to a unique, long-acting and broad spectrum, Eph receptor therapeutic antagonist.Exosomes mediate cell contact-independent ephrin-Eph signaling during axon guidance.The SAM domain inhibits EphA2 interactions in the plasma membrane.The Neural Cell Adhesion Molecule (NCAM) Promotes Clustering and Activation of EphA3 Receptors in GABAergic Interneurons to Induce Ras Homolog Gene Family, Member A (RhoA)/Rho-associated protein kinase (ROCK)-mediated Growth Cone Collapse.Identification of new EphA4 inhibitors by virtual screening of FDA-approved drugs.Interactions of the EphA2 Kinase Domain with PIPs in Membranes: Implications for Receptor Function.Specific Eph receptor-cytoplasmic effector signaling mediated by SAM-SAM domain interactions.Eph/Ephrin-mediated stimulation of human bone marrow mesenchymal stromal cells correlates with changes in cell adherence and increased cell death.The EphA2 receptor is activated through induction of distinct, ligand-dependent oligomeric structures
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P2860
Structurally encoded intraclass differences in EphA clusters drive distinct cell responses
description
2013 nî lūn-bûn
@nan
2013 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Structurally encoded intraclas ...... drive distinct cell responses
@ast
Structurally encoded intraclas ...... drive distinct cell responses
@en
Structurally encoded intraclas ...... drive distinct cell responses
@nl
type
label
Structurally encoded intraclas ...... drive distinct cell responses
@ast
Structurally encoded intraclas ...... drive distinct cell responses
@en
Structurally encoded intraclas ...... drive distinct cell responses
@nl
prefLabel
Structurally encoded intraclas ...... drive distinct cell responses
@ast
Structurally encoded intraclas ...... drive distinct cell responses
@en
Structurally encoded intraclas ...... drive distinct cell responses
@nl
P2093
P2860
P50
P3181
P356
P1476
Structurally encoded intraclas ...... drive distinct cell responses
@en
P2093
A Radu Aricescu
Andreas Schaupp
Karl Harlos
Nikolaos Mitakidis
Rainer Kaufmann
P2860
P2888
P304
P3181
P356
10.1038/NSMB.2617
P577
2013-06-30T00:00:00Z
P5875
P6179
1035736427