Discovery of Novel Small-Molecule Inhibitors of BRD4 Using Structure-Based Virtual Screening
about
Identification of druggable cancer driver genes amplified across TCGA datasetsThe bromodomain: from epigenome reader to druggable targetDual kinase-bromodomain inhibitors for rationally designed polypharmacologyTargeting bromodomains: epigenetic readers of lysine acetylationTargeting BET bromodomains for cancer treatmentDrug Discovery Targeting Bromodomain-Containing Protein 4.Modular o-quinone catalyst system for dehydrogenation of tetrahydroquinolines under ambient conditions.The essential roles of chemistry in high-throughput screening triageA novel caspase 8 selective small molecule potentiates TRAIL-induced cell death.State-of-the-art strategies for targeting protein-protein interactions by small-molecule inhibitors.NMR-based platform for fragment-based lead discovery used in screening BRD4-targeted compoundsMolecular docking and dynamics simulation study of flavonoids as BET bromodomain inhibitors.Large-Scale Computational Screening Identifies First in Class Multitarget Inhibitor of EGFR Kinase and BRD4.Accurate calculation of the absolute free energy of binding for drug molecules.Phenotypic screening and fragment-based approaches to the discovery of small-molecule bromodomain ligands.Bromodomains and their pharmacological inhibitors.A Computational Investigation of Small-Molecule Engagement of Hot Spots at Protein-Protein Interaction Interfaces.Fragment-Based Drug Discovery in the Bromodomain and Extra-Terminal Domain Family.Discovery of a Chemical Tool Inhibitor Targeting the Bromodomains of TRIM24 and BRPF.The Development of Target-Specific Pose Filter Ensembles To Boost Ligand Enrichment for Structure-Based Virtual Screening.Target-based molecular modeling strategies for schistosomiasis drug discovery.Rapid activity prediction of HIV-1 integrase inhibitors: harnessing docking energetic components for empirical scoring by chemometric and artificial neural network approaches.9H-purine scaffold reveals induced-fit pocket plasticity of the BRD9 bromodomainStructure enabled design of BAZ2-ICR, a chemical probe targeting the bromodomains of BAZ2A and BAZ2B.Identification of a Novel Class of BRD4 Inhibitors by Computational Screening and Binding Simulations.A new quinoline BRD4 inhibitor targets a distinct latent HIV-1 reservoir for re-activation from other 'shock' drugs.In silico structure-based approaches to discover protein-protein interaction-targeting drugs.Relative Binding Free Energy Calculations Applied to Protein Homology Models.A facile and general acid-catalyzed deuteration at methyl groups of N-heteroarylmethanes.Pharmacophore-based virtual screening, molecular docking, molecular dynamics simulation, and biological evaluation for the discovery of novel BRD4 inhibitors.Identification of novel small-molecule inhibitors targeting menin-MLL interaction, repurposing the antidiarrheal loperamide.Discovery of BET bromodomain inhibitors and their role in target validationComputer-Aided Drug Design in Epigenetics.Structure-based virtual screening of novel, high-affinity BRD4 inhibitorsMolecular Docking Study Characterization of Rare Flavonoids at the Nac-Binding Site of the First Bromodomain of BRD4 (BRD4 BD1)
P2860
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P2860
Discovery of Novel Small-Molecule Inhibitors of BRD4 Using Structure-Based Virtual Screening
description
2013 nî lūn-bûn
@nan
2013 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Discovery of Novel Small-Molec ...... ucture-Based Virtual Screening
@ast
Discovery of Novel Small-Molec ...... ucture-Based Virtual Screening
@en
Discovery of Novel Small-Molec ...... ucture-Based Virtual Screening
@nl
type
label
Discovery of Novel Small-Molec ...... ucture-Based Virtual Screening
@ast
Discovery of Novel Small-Molec ...... ucture-Based Virtual Screening
@en
Discovery of Novel Small-Molec ...... ucture-Based Virtual Screening
@nl
prefLabel
Discovery of Novel Small-Molec ...... ucture-Based Virtual Screening
@ast
Discovery of Novel Small-Molec ...... ucture-Based Virtual Screening
@en
Discovery of Novel Small-Molec ...... ucture-Based Virtual Screening
@nl
P2093
P2860
P50
P3181
P356
P1476
Discovery of Novel Small-Molec ...... ucture-Based Virtual Screening
@en
P2093
Michael Tomsett
Sarah Martin
Swen Hoelder
P2860
P304
P3181
P356
10.1021/JM4011302
P407
P50
P577
2013-10-24T00:00:00Z