Computational Design of the Affinity and Specificity of a Therapeutic T Cell Receptor - Wikidata - awgldk - TriplyDB

Computational Design of the Affinity and Specificity of a Therapeutic T Cell Receptor

Computational Design of the Affinity and Specificity of a Therapeutic T Cell Receptor

http://www.wikidata.org/entity/Q27681832

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T-cell receptor gene therapy--ready to go viral?DynaDom: structure-based prediction of T cell receptor inter-domain and T cell receptor-peptide-MHC (class I) association angles.Citizens unite for computational immunology!How structural adaptability exists alongside HLA-A2 bias in the human αβ TCR repertoire Specific roles of each TCR hemichain in generating functional chain-centric TCR.Clonotypically similar hybrid αβ T cell receptors can exhibit markedly different surface expression, antigen specificity and cross-reactivity.Deep Mutational Scans as a Guide to Engineering High Affinity T Cell Receptor Interactions with Peptide-bound Major Histocompatibility Complex.An Engineered Switch in T Cell Receptor Specificity Leads to an Unusual but Functional Binding Geometry.Using Global Analysis to Extend the Accuracy and Precision of Binding Measurements with T cell Receptors and Their Peptide/MHC Ligands.Antigen-specific vaccines for cancer treatment.New approaches for the immunotherapy of acute myeloid leukemia.Driving gene-engineered T cell immunotherapy of cancer.A generalized framework for computational design and mutational scanning of T-cell receptor binding interfaces.Hepatitis C virus-cross-reactive TCR gene-modified T cells: a model for immunotherapy against diseases with genomic instability.Critical biological parameters modulate affinity as a determinant of function in T-cell receptor gene-modified T-cells.Differential scanning fluorimetry based assessments of the thermal and kinetic stability of peptide-MHC complexes.Affinity maturation of a broadly neutralizing human monoclonal antibody that prevents acute hepatitis C virus infection in mice.Changing the peptide specificity of a human T-cell receptor by directed evolution.Interpreting T-Cell Cross-reactivity through Structure: Implications for TCR-Based Cancer Immunotherapy.Identification of the cognate peptide-MHC target of T cell receptors using molecular modeling and force field scoring.Selection of PD1/PD-L1 X-Aptamers.ATLAS: A database linking binding affinities with structures for wild-type and mutant TCR-pMHC complexes.Immunology: The patterns of T-cell target recognition.iCFN: an efficient exact algorithm for multistate protein design

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Computational Design of the Affinity and Specificity of a Therapeutic T Cell Receptor

http://www.wikidata.org/entity/Q27681832

description

2014 nî lūn-bûn

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2014 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2014 թվականի փետրվարին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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name

Computational Design of the Affinity and Specificity of a Therapeutic T Cell Receptor

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Computational Design of the Affinity and Specificity of a Therapeutic T Cell Receptor

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Computational Design of the Affinity and Specificity of a Therapeutic T Cell Receptor

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type

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Computational Design of the Affinity and Specificity of a Therapeutic T Cell Receptor

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Computational Design of the Affinity and Specificity of a Therapeutic T Cell Receptor

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Computational Design of the Affinity and Specificity of a Therapeutic T Cell Receptor

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Computational Design of the Affinity and Specificity of a Therapeutic T Cell Receptor

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Computational Design of the Affinity and Specificity of a Therapeutic T Cell Receptor

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Computational Design of the Affinity and Specificity of a Therapeutic T Cell Receptor

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JOURNAL.PCBI.1003478

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PLOS Computational Biology

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Computational Design of the Affinity and Specificity of a Therapeutic T Cell Receptor

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Brian M Baker

http://www.w3.org/2001/XMLSchema#string

Craig W Vander Kooi

http://www.w3.org/2001/XMLSchema#string

Lance M Hellman

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Moushumi Hossain

http://www.w3.org/2001/XMLSchema#string

Nishant K Singh

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Zhiping Weng

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P2860

Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen

MolProbity: all-atom structure validation for macromolecular crystallography

Cancer regression in patients after transfer of genetically engineered lymphocytes

The structure and stability of an HLA-A*0201/octameric tax peptide complex with an empty conserved peptide-N-terminal binding site

A T cell receptor flattens a bulged antigenic peptide presented by a major histocompatibility complex class I molecule

How a single T cell receptor recognizes both self and foreign MHC

Crystal structures of high affinity human T-cell receptors bound to peptide major histocompatibility complex reveal native diagonal binding geometry

Structures of MART-126/27–35 Peptide/HLA-A2 Complexes Reveal a Remarkable Disconnect between Antigen Structural Homology and T Cell Recognition

Different Thermodynamic Binding Mechanisms and Peptide Fine Specificities Associated with a Panel of Structurally Similar High-Affinity T Cell Receptors † ‡

Germ Line-governed Recognition of a Cancer Epitope by an Immunodominant Human T-cell Receptor

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e1003478

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scholarly article

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10.1371/JOURNAL.PCBI.1003478

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2

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10

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2014-02-01T00:00:00Z

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260254373

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24550723

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3923660

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