Application of fragment screening and merging to the discovery of inhibitors of the Mycobacterium tuberculosis cytochrome P450 CYP121
about
Substrate and Reaction Specificity of Mycobacterium tuberculosis Cytochrome P450 CYP121: INSIGHTS FROM BIOCHEMICAL STUDIES AND CRYSTAL STRUCTURESOvercoming the Limitations of Fragment Merging: Rescuing a Strained Merged Fragment Series TargetingMycobacterium tuberculosisCYP121Structural Insights into the Mechanism for Recognizing Substrate of the Cytochrome P450 Enzyme TxtEIncreasing Chemical Space Coverage by Combining Empirical and Computational Fragment ScreensFragment-Based Discovery of 6-Azaindazoles As Inhibitors of Bacterial DNA LigaseStructural Characterization and Ligand/Inhibitor Identification Provide Functional Insights into the Mycobacterium tuberculosis Cytochrome P450 CYP126A1A three-stage biophysical screening cascade for fragment-based drug discovery.Biofragments: an approach towards predicting protein function using biologically related fragments and its application to Mycobacterium tuberculosis CYP126.Investigation of the mycobacterial enzyme HsaD as a potential novel target for anti-tubercular agents using a fragment-based drug design approach.Synthesis, biological evaluation, and molecular docking studies of novel 3-aryl-5-(alkyl-thio)-1H-1,2,4-triazoles derivatives targeting Mycobacterium tuberculosis.Fragment-Based Approaches to the Development of Mycobacterium tuberculosis CYP121 Inhibitors.Solution NMR Studies of Mycobacterium tuberculosis Proteins for Antibiotic Target Discovery.Biophysical Screening of a Focused Library for the Discovery of CYP121 Inhibitors as Novel Antimycobacterials.A homeotropic main-chain tolane-type liquid crystal elastomer film exhibiting high anisotropic thermal conductivity.Quantum Mechanics/Molecular Mechanics Modeling of Enzymatic Processes: Caveats and Breakthroughs.Substrate Fragmentation for the Design of M. tuberculosis CYP121 Inhibitors.QM/MM study of the C-C coupling reaction mechanism of CYP121, an essential cytochrome p450 of Mycobacterium tuberculosis.Cross-linking of dicyclotyrosine by the cytochrome P450 enzyme CYP121 from Mycobacterium tuberculosis proceeds through a catalytic shunt pathway.Novel Aryl Substituted Pyrazoles as Small Molecule Inhibitors of Cytochrome P450 CYP121A1: Synthesis and Antimycobacterial Evaluation.Potential drug targets in the Mycobacterium tuberculosis cytochrome P450 system.Discovery of Inhibitors of Protein-Protein Interactions Using Fragment-Based Methods
P2860
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P2860
Application of fragment screening and merging to the discovery of inhibitors of the Mycobacterium tuberculosis cytochrome P450 CYP121
description
2012 nî lūn-bûn
@nan
2012 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Application of fragment screen ...... culosis cytochrome P450 CYP121
@ast
Application of fragment screen ...... culosis cytochrome P450 CYP121
@en
Application of fragment screen ...... culosis cytochrome P450 CYP121
@nl
type
label
Application of fragment screen ...... culosis cytochrome P450 CYP121
@ast
Application of fragment screen ...... culosis cytochrome P450 CYP121
@en
Application of fragment screen ...... culosis cytochrome P450 CYP121
@nl
prefLabel
Application of fragment screen ...... culosis cytochrome P450 CYP121
@ast
Application of fragment screen ...... culosis cytochrome P450 CYP121
@en
Application of fragment screen ...... culosis cytochrome P450 CYP121
@nl
P2093
P2860
P50
P3181
P356
P1476
Application of fragment screen ...... culosis cytochrome P450 CYP121
@en
P2093
Andrew W Munro
Kirsty J McLean
Sachin Surade
Sean A Hudson
Yong-Qing Yang
P2860
P304
P3181
P356
10.1002/ANIE.201202544
P407
P577
2012-09-10T00:00:00Z