Expanding the Binding Envelope of CYP51 Inhibitors TargetingTrypanosoma cruziwith 4-Aminopyridyl-Based Sulfonamide Derivatives
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4-Aminopyridyl-Based CYP51 Inhibitors as Anti- Trypanosoma cruzi Drug Leads with Improved Pharmacokinetic Profile and in Vivo PotencyThe Potential of Secondary Metabolites from Plants as Drugs or Leads against Protozoan Neglected Diseases-Part III: In-Silico Molecular Docking InvestigationsTargeting Ergosterol biosynthesis in Leishmania donovani: essentiality of sterol 14 alpha-demethylaseDrug strategies targeting CYP51 in neglected tropical diseasesBinding mode and potency of N-indolyloxopyridinyl-4-aminopropanyl-based inhibitors targeting Trypanosoma cruzi CYP51.CYP51 is an essential drug target for the treatment of primary amoebic meningoencephalitis (PAM).4-aminopyridyl-based lead compounds targeting CYP51 prevent spontaneous parasite relapse in a chronic model and improve cardiac pathology in an acute model of Trypanosoma cruzi infection.3-pyridyl inhibitors with novel activity against Trypanosoma cruzi reveal in vitro profiles can aid prediction of putative cytochrome P450 inhibition.
P2860
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P2860
Expanding the Binding Envelope of CYP51 Inhibitors TargetingTrypanosoma cruziwith 4-Aminopyridyl-Based Sulfonamide Derivatives
description
2014 nî lūn-bûn
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2014 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Expanding the Binding Envelope ...... -Based Sulfonamide Derivatives
@ast
Expanding the Binding Envelope ...... -Based Sulfonamide Derivatives
@en
Expanding the Binding Envelope ...... -Based Sulfonamide Derivatives
@nl
type
label
Expanding the Binding Envelope ...... -Based Sulfonamide Derivatives
@ast
Expanding the Binding Envelope ...... -Based Sulfonamide Derivatives
@en
Expanding the Binding Envelope ...... -Based Sulfonamide Derivatives
@nl
prefLabel
Expanding the Binding Envelope ...... -Based Sulfonamide Derivatives
@ast
Expanding the Binding Envelope ...... -Based Sulfonamide Derivatives
@en
Expanding the Binding Envelope ...... -Based Sulfonamide Derivatives
@nl
P2093
P2860
P356
P1433
P1476
Expanding the Binding Envelope ...... -Based Sulfonamide Derivatives
@en
P2093
Debora F Vieira
Jun Yong Choi
Larissa M Podust
William R Roush
P2860
P304
P356
10.1002/CBIC.201402027
P577
2014-05-26T00:00:00Z