Structural basis of human CYP51 inhibition by antifungal azoles
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Molecular modelling of the emergence of azole resistance in Mycosphaerella graminicolaStructural basis of drug binding to CYP46A1, an enzyme that controls cholesterol turnover in the brainStructural basis for pregnenolone biosynthesis by the mitochondrial monooxygenase systemStructural insights into aldosterone synthase substrate specificity and targeted inhibitionStructural diversity of eukaryotic membrane cytochrome p450sStructural Insights into Binding of the Antifungal Drug Fluconazole to Saccharomyces cerevisiae Lanosterol 14α-Demethylase.Pharmacological Characterization, Structural Studies, and In Vivo Activities of Anti-Chagas Disease Lead Compounds Derived from TipifarnibConformational Adaptation of Human Cytochrome P450 2B6 and Rabbit Cytochrome P450 2B4 Revealed upon Binding Multiple Amlodipine MoleculesThe Protein Maker: an automated system for high-throughput parallel purificationStructural complex of sterol 14 -demethylase (CYP51) with 14 -methylenecyclopropyl- 7-24, 25-dihydrolanosterolAntifungal Azoles: Structural Insights into Undesired Tight Binding to Cholesterol-Metabolizing CYP46A1Complexes of Trypanosoma cruzi Sterol 14 -Demethylase (CYP51) with Two Pyridine-based Drug Candidates for Chagas Disease: STRUCTURAL BASIS FOR PATHOGEN SELECTIVITYArchitecture of a single membrane spanning cytochrome P450 suggests constraints that orient the catalytic domain relative to a bilayerExpanding the Binding Envelope of CYP51 Inhibitors TargetingTrypanosoma cruziwith 4-Aminopyridyl-Based Sulfonamide DerivativesTriazole fungicides can induce cross-resistance to medical triazoles in Aspergillus fumigatusDiscovery of a novel dual fungal CYP51/human 5-lipoxygenase inhibitor: implications for anti-fungal therapyMicrobial cytochromes P450: biodiversity and biotechnology. Where do cytochromes P450 come from, what do they do and what can they do for us?Biosynthesis of cholesterol and other sterolsFungal cytochrome P450 sterol 14α-demethylase (CYP51) and azole resistance in plant and human pathogens.Polymorphisms of CYP51A1 from cholesterol synthesis: associations with birth weight and maternal lipid levels and impact on CYP51 protein structure.Modelling inhibition of avian aromatase by azole pesticides.The role of cytochrome P450 2B6 and 2B4 substrate access channel residues predicted based on crystal structures of the amlodipine complexesEvaluation of Selected CYP51A1 Polymorphisms in View of Interactions with Substrate and Redox Partner.Amino acid substitutions at the major insertion loop of Candida albicans sterol 14alpha-demethylase are involved in fluconazole resistance.Identification, modeling and ligand affinity of early deuterostome CYP51s, and functional characterization of recombinant zebrafish sterol 14α-demethylaseExpression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.Three-dimensional structure of steroid 21-hydroxylase (cytochrome P450 21A2) with two substrates reveals locations of disease-associated variantsResistance to antifungals that target CYP51.Sterols in spermatogenesis and sperm maturation.Econazole Nitrate Induces Apoptosis in MCF-7 Cells via Mitochondrial and Caspase PathwaysRecent Structural Insights into Cytochrome P450 Function.The clinical candidate VT-1161 is a highly potent inhibitor of Candida albicans CYP51 but fails to bind the human enzyme.Drug strategies targeting CYP51 in neglected tropical diseasesMechanism of binding of prothioconazole to Mycosphaerella graminicola CYP51 differs from that of other azole antifungalsHeterologous expression and characterization of the sterol 14α-demethylase CYP51F1 from Candida albicansInteractions of antiparasitic sterols with sterol 14α-demethylase (CYP51) of human pathogensUndifferentiated State Induced by Rb-p53 Double Inactivation in Mouse Thyroid Neuroendocrine Cells and Embryonic Fibroblasts.Azole fungicides - understanding resistance mechanisms in agricultural fungal pathogens.The Investigational Drug VT-1129 Is a Highly Potent Inhibitor of Cryptococcus Species CYP51 but Only Weakly Inhibits the Human Enzyme.Azole Antifungal Sensitivity of Sterol 14α-Demethylase (CYP51) and CYP5218 from Malassezia globosa
P2860
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P2860
Structural basis of human CYP51 inhibition by antifungal azoles
description
2010 nî lūn-bûn
@nan
2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Structural basis of human CYP51 inhibition by antifungal azoles
@ast
Structural basis of human CYP51 inhibition by antifungal azoles
@en
Structural basis of human CYP51 inhibition by antifungal azoles
@nl
type
label
Structural basis of human CYP51 inhibition by antifungal azoles
@ast
Structural basis of human CYP51 inhibition by antifungal azoles
@en
Structural basis of human CYP51 inhibition by antifungal azoles
@nl
prefLabel
Structural basis of human CYP51 inhibition by antifungal azoles
@ast
Structural basis of human CYP51 inhibition by antifungal azoles
@en
Structural basis of human CYP51 inhibition by antifungal azoles
@nl
P2093
P3181
P1476
Structural basis of human CYP51 inhibition by antifungal azoles
@en
P2093
Hee-Won Park
Natallia Strushkevich
Sergey A Usanov
P304
P3181
P356
10.1016/J.JMB.2010.01.075
P407
P577
2010-04-09T00:00:00Z