Structure of the DDB1–CRBN E3 ubiquitin ligase in complex with thalidomide - Wikidata - awgldk - TriplyDB

Structure of the DDB1–CRBN E3 ubiquitin ligase in complex with thalidomide

Structure of the DDB1–CRBN E3 ubiquitin ligase in complex with thalidomide

http://www.wikidata.org/entity/Q27684738

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Drugging the undruggables: exploring the ubiquitin system for drug development Regulating the Regulators: Recent Revelations in the Control of E3 Ubiquitin Ligases Novel drug targets for personalized precision medicine in relapsed/refractory diffuse large B-cell lymphoma: a comprehensive review The DDB1-DCAF1-Vpr-UNG2 crystal structure reveals how HIV-1 Vpr steers human UNG2 toward destruction Thalidomide-induced teratogenesis: history and mechanisms Distinct and overlapping functions of the cullin E3 ligase scaffolding proteins CUL4A and CUL4B The thalidomide-binding domain of cereblon defines the CULT domain family and is a new member of the β-tent fold Establishment of a Wheat Cell-Free Synthesized Protein Array Containing 250 Human and Mouse E3 Ubiquitin Ligases to Identify Novel Interaction between E3 Ligases and Substrate Proteins DRUG DEVELOPMENT. Phthalimide conjugation as a strategy for in vivo target protein degradation Correlating chemical sensitivity and basal gene expression reveals mechanism of action.Structural studies reveal thalidomide's mechanism of action and clinical effects: crystal clear or clearly complexed?Inhibitors of ubiquitin E3 ligase as potential new antimalarial drug leads.Rational Tuning of Visual Cycle Modulator Pharmacodynamics Choose and Use Your Chemical Probe Wisely to Explore Cancer Biology.Targeting Cullin-RING E3 ubiquitin ligases for drug discovery: structure, assembly and small-molecule modulation.Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4.Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS.Induced protein degradation: an emerging drug discovery paradigm.Differentiation of antiinflammatory and antitumorigenic properties of stabilized enantiomers of thalidomide analogs Protein ubiquitination in lymphoid malignancies.Crystal structure of (S)-4-carbamoyl-4-(1,3-dioxo-isoindolin-2-yl)butanoic acid.Preeclampsia - will orphan drug status facilitate innovative biological therapies?Sculpting the proteome with small molecules CC-122, a pleiotropic pathway modifier, mimics an interferon response and has antitumor activity in DLBCL.Structural dynamics of the cereblon ligand binding domain.Ubiquitylation of nuclear receptors: new linkages and therapeutic implications.Clinical and pharmacodynamic analysis of pomalidomide dosing strategies in myeloma: impact of immune activation and cereblon targets.Expression of the cereblon binding protein argonaute 2 plays an important role for multiple myeloma cell growth and survival.A novel effect of thalidomide and its analogs: suppression of cereblon ubiquitination enhances ubiquitin ligase function The novel mechanism of lenalidomide activity.Structural basis of PROTAC cooperative recognition for selective protein degradation Chemical approaches to targeted protein degradation through modulation of the ubiquitin-proteasome pathway Targeting Transcription Factors in Cancer The IMiDs targets IKZF-1/3 and IRF4 as novel negative regulators of NK cell-activating ligands expression in multiple myeloma The CUL4-DDB1 ubiquitin ligase complex controls adult and embryonic stem cell differentiation and homeostasis Suramin inhibits cullin-RING E3 ubiquitin ligases.SPLINTS: small-molecule protein ligand interface stabilizers.Glutamine Triggers Acetylation-Dependent Degradation of Glutamine Synthetase via the Thalidomide Receptor Cereblon.In silico analysis of enantioselective binding of immunomodulatory imide drugs to cereblon.Targeting ubiquitination for cancer therapies.

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P2860

Structure of the DDB1–CRBN E3 ubiquitin ligase in complex with thalidomide

http://www.wikidata.org/entity/Q27684738

description

2014 nî lūn-bûn

@nan

2014 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2014年の論文

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2014年論文

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2014年論文

@zh-hant

2014年論文

@zh-hk

2014年論文

@zh-mo

2014年論文

@zh-tw

2014年论文

@wuu

name

Structure of the DDB1–CRBN E3 ubiquitin ligase in complex with thalidomide

@ast

Structure of the DDB1–CRBN E3 ubiquitin ligase in complex with thalidomide

@en

Structure of the DDB1–CRBN E3 ubiquitin ligase in complex with thalidomide

@nl

type

label

Structure of the DDB1–CRBN E3 ubiquitin ligase in complex with thalidomide

@ast

Structure of the DDB1–CRBN E3 ubiquitin ligase in complex with thalidomide

@en

Structure of the DDB1–CRBN E3 ubiquitin ligase in complex with thalidomide

@nl

prefLabel

Structure of the DDB1–CRBN E3 ubiquitin ligase in complex with thalidomide

@ast

Structure of the DDB1–CRBN E3 ubiquitin ligase in complex with thalidomide

@en

Structure of the DDB1–CRBN E3 ubiquitin ligase in complex with thalidomide

@nl

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P1476

Structure of the DDB1–CRBN E3 ubiquitin ligase in complex with thalidomide

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Fabrizio Serluca

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Gondichatnahalli M Lingaraju

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Haidi Yang

http://www.w3.org/2001/XMLSchema#string

Jane Nagel

http://www.w3.org/2001/XMLSchema#string

Jeremy L Jenkins

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Johannes Ottl

http://www.w3.org/2001/XMLSchema#string

John R Lydeard

http://www.w3.org/2001/XMLSchema#string

Kerstin Böhm

http://www.w3.org/2001/XMLSchema#string

Marc Hild

http://www.w3.org/2001/XMLSchema#string

Markus Schirle

http://www.w3.org/2001/XMLSchema#string

P2860

A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1

Identification of a primary target of thalidomide teratogenicity

Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery

Mutations in UVSSA cause UV-sensitive syndrome and destabilize ERCC6 in transcription-coupled DNA repair

Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex

Structural basis of UV DNA-damage recognition by the DDB1-DDB2 complex

A mutation in a novel ATP-dependent Lon protease gene in a kindred with mild mental retardation

Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes

Thalidomide is an inhibitor of angiogenesis

COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer

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49-53

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scholarly article

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1116370

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10.1038/NATURE13527

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7512

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512

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Eric S. Fischer

Jeffrey W. Harper

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2014-08-07T00:00:00Z

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264091801

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1028080932

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4423819

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