Molecular basis of selective inhibition and slow reversibility of avibactam against class D carbapenemases: a structure-guided study of OXA-24 and OXA-48
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New β-Lactamase Inhibitors in the ClinicStructural Basis for Different Substrate Profiles of Two Closely Related Class D β-Lactamases and Their Inhibition by HalogensTargeting Antibiotic ResistanceInvestigations on recyclisation and hydrolysis in avibactam mediated serine β-lactamase inhibitionRecent contributions of structure-based drug design to the development of antibacterial compounds.Inhibition of Klebsiella β-Lactamases (SHV-1 and KPC-2) by Avibactam: A Structural Study.Treatment options for infections caused by carbapenem-resistant Enterobacteriaceae: can we apply "precision medicine" to antimicrobial chemotherapy?The road to avibactam: the first clinically useful non-β-lactam working somewhat like a β-lactam.Recent Advances in the Rational Design and Optimization of Antibacterial Agents.Emerging Issues and Treatment Strategies in Carbapenem-Resistant Enterobacteriaceae (CRE).Structural/mechanistic insights into the efficacy of non-classical β-lactamase inhibitors against extensively drug resistant Stenotrophomonas maltophilia clinical isolates.Activity of the β-Lactamase inhibitor LN-1-255 against carbapenem-hydrolyzing class D β-lactamases from Acinetobacter baumannii.ETX2514 is a broad-spectrum β-lactamase inhibitor for the treatment of drug-resistant Gram-negative bacteria including Acinetobacter baumannii.Prediction of in vivo and in vitro infection model results using a semimechanistic model of avibactam and aztreonam combination against multidrug resistant organisms.In vitro activity of ceftazidime/avibactam against urinary isolates from patients in a Phase 3 clinical trial programme for the treatment of complicated urinary tract infections.Active-Site Plasticity Is Essential to Carbapenem Hydrolysis by OXA-58 Class D β-Lactamase of Acinetobacter baumannii.Antibiotics: Precious Goods in Changing Times.Structural and sequence analysis of class A β-lactamases with respect to avibactam inhibition: impact of Ω-loop variations.In vitro pharmacokinetics/pharmacodynamics of the combination of avibactam and aztreonam against MDR organisms.LN-1-255, a penicillanic acid sulfone able to inhibit the class D carbapenemase OXA-48.Exploring the Landscape of Diazabicyclooctane (DBO) Inhibition: Avibactam Inactivation of PER-2 β-Lactamase.Pharmacological aspects and spectrum of action of ceftazidime-avibactam: a systematic review.13C-Carbamylation as a mechanistic probe for the inhibition of class D β-lactamases by avibactam and halide ions.Exploring Additional Dimensions of Complexity in Inhibitor Design for Serine β-Lactamases: Mechanistic and Intra- and Inter-molecular Chemistry Approaches.In Vitro Activity of Ceftazidime-Avibactam Against Isolates from Patients in a Phase 3 Clinical Trial for the Treatment of Complicated Intra-Abdominal Infections.
P2860
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P2860
Molecular basis of selective inhibition and slow reversibility of avibactam against class D carbapenemases: a structure-guided study of OXA-24 and OXA-48
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2015 nî lūn-bûn
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2015 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2015年の論文
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2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
name
Molecular basis of selective i ...... ded study of OXA-24 and OXA-48
@ast
Molecular basis of selective i ...... ded study of OXA-24 and OXA-48
@en
Molecular basis of selective i ...... ded study of OXA-24 and OXA-48
@nl
type
label
Molecular basis of selective i ...... ded study of OXA-24 and OXA-48
@ast
Molecular basis of selective i ...... ded study of OXA-24 and OXA-48
@en
Molecular basis of selective i ...... ded study of OXA-24 and OXA-48
@nl
prefLabel
Molecular basis of selective i ...... ded study of OXA-24 and OXA-48
@ast
Molecular basis of selective i ...... ded study of OXA-24 and OXA-48
@en
Molecular basis of selective i ...... ded study of OXA-24 and OXA-48
@nl
P2093
P50
P3181
P356
P1433
P1476
Molecular basis of selective i ...... ded study of OXA-24 and OXA-48
@en
P2093
David E Ehmann
Haris Jahić
Richard A Alm
Sushmita D Lahiri
Thomas F Durand-Reville
P304
P3181
P356
10.1021/CB500703P
P577
2015-02-20T00:00:00Z