Structural basis for subtype-specific inhibition of the P2X7 receptor.
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Localization of the gate and selectivity filter of the full-length P2X7 receptorUnique residues in the ATP gated human P2X7 receptor define a novel allosteric binding pocket for the selective antagonist AZ10606120.Structural insights into the nucleotide base specificity of P2X receptors.Design, synthesis and evaluation in an LPS rodent model of neuroinflammation of a novel 18F-labelled PET tracer targeting P2X7.On the permeation of large organic cations through the pore of ATP-gated P2X receptors.The P2X7 Receptor-Interleukin-1 Liaison.P2X Receptor Activation.Expression and Purification of a Mammalian P2X7 Receptor from Sf9 Insect Cells.The P2X7 receptor forms a dye-permeable pore independent of its intracellular domain but dependent on membrane lipid composition.Structural insights into the competitive inhibition of the ATP-gated P2X receptor channelProbenecid directly impairs activation of the canine P2X7 receptor.The potential of P2X7 receptors as a therapeutic target, including inflammation and tumour progression.P2X4 Receptor in Silico and Electrophysiological Approaches Reveal Insights of Ivermectin and Zinc Allosteric Modulation.Non-nucleotide Agonists Triggering P2X7 Receptor Activation and Pore Formation.The Molecular Determinants of Small-Molecule Ligand Binding at P2X Receptors.Recent Advances in CNS P2X7 Physiology and Pharmacology: Focus on Neuropsychiatric Disorders.The P2X7 Receptor.Intersubunit physical couplings fostered by the left flipper domain facilitate channel opening of P2X4 receptors.Druggable negative allosteric site of P2X3 receptors.Mapping the Allosteric Action of Antagonists A740003 and A438079 Reveals a Role for the Left Flipper in Ligand Sensitivity at P2X7 Receptors.Zidovudine ameliorates pathology in the mouse model of Duchenne muscular dystrophy via P2RX7 purinoceptor antagonism.
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P2860
Structural basis for subtype-specific inhibition of the P2X7 receptor.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 09 December 2016
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Structural basis for subtype-specific inhibition of the P2X7 receptor.
@en
Structural basis for subtype-specific inhibition of the P2X7 receptor.
@nl
type
label
Structural basis for subtype-specific inhibition of the P2X7 receptor.
@en
Structural basis for subtype-specific inhibition of the P2X7 receptor.
@nl
prefLabel
Structural basis for subtype-specific inhibition of the P2X7 receptor.
@en
Structural basis for subtype-specific inhibition of the P2X7 receptor.
@nl
P2860
P356
P1433
P1476
Structural basis for subtype-specific inhibition of the P2X7 receptor
@en
P2093
Akira Karasawa
P2860
P356
10.7554/ELIFE.22153
P407
P577
2016-12-09T00:00:00Z