The three-dimensional structure of Asn102 mutant of trypsin: role of Asp102 in serine protease catalysis
about
Cholinesterase-like domains in enzymes and structural proteins: functional and evolutionary relationships and identification of a catalytically essential aspartic acidSite-directed mutagenesis of the proposed catalytic amino acids of the Sindbis virus capsid protein autoproteaseStructural requirements of pyrroloquinoline quinone dependent enzymatic reactionsMolecular mechanisms for the conversion of zymogens to active proteolytic enzymesComplement factor D, a novel serine proteaseStructural basis of profactor D activation: from a highly flexible zymogen to a novel self-inhibited serine protease, complement factor DComparison of anionic and cationic trypsinogens: The anionic activation domain is more flexible in solution and differs in its mode of BPTI binding in the crystal structureGlutamate 170 of human l-3-hydroxyacyl-CoA dehydrogenase is required for proper orientation of the catalytic histidine and structural integrity of the enzymeStructural investigations of the active-site mutant Asn156Ala of outer membrane phospholipase A: Function of the Asn-His interaction in the catalytic triadSubstrate-dependent competency of the catalytic triad of prolyl oligopeptidaseStructure and Catalysis of Acylaminoacyl Peptidase: CLOSED AND OPEN SUBUNITS OF A DIMER OLIGOPEPTIDASEThe catalytic aspartate is protonated in the Michaelis complex formed between trypsin and an in vitro evolved substrate-like inhibitor: a refined mechanism of serine protease actionInactivation of the Mycobacterium tuberculosis Antigen 85 Complex by Covalent, Allosteric InhibitorsLoop Electrostatics Asymmetry Modulates the Preexisting Conformational Equilibrium in ThrombinCrystal structure of a complement factor D mutant expressing enhanced catalytic activityStructural basis of substrate specificity in the serine proteasesCharacterization of Bafinivirus main protease autoprocessing activities.Characterization of a torovirus main proteinaseCysteine proteases of positive strand RNA viruses and chymotrypsin-like serine proteases. A distinct protein superfamily with a common structural fold.B. subtilis ykuD protein at 2.0 A resolution: insights into the structure and function of a novel, ubiquitous family of bacterial enzymesA study of the stabilization of tetrahedral adducts by trypsin and delta-chymotrypsin.Crystallographic and biochemical investigations of kumamolisin-As, a serine-carboxyl peptidase with collagenase activity.Histidine pKa shifts accompanying the inactivating Asp121----Asn substitution in a semisynthetic bovine pancreatic ribonucleaseHis...Asp catalytic dyad of ribonuclease A: structure and function of the wild-type, D121N, and D121A enzymes.Mutational analysis of the Drosophila snake protease: an essential role for domains within the proenzyme polypeptide chain.A norovirus protease structure provides insights into active and substrate binding site integritySite-directed mutagenesis study of yeast peptide:N-glycanase. Insight into the reaction mechanism of deglycosylation.Human gamma-glutamyl transpeptidase mutants involving conserved aspartate residues and the unique cysteine residue of the light subunit.Identification of active-site amino acid residues in the Chiba virus 3C-like proteaseThe family of glycogen phosphorylases: structure and function.Poliovirus thiol proteinase 3C can utilize a serine nucleophile within the putative catalytic triad.Why Ser and not Thr brokers catalysis in the trypsin foldInternal water molecules and H-bonding in biological macromolecules: a review of structural features with functional implications."Mirror image" antagonists of thrombin-induced platelet activation based on thrombin receptor structureDual Mutation Events in the Haemagglutinin-Esterase and Fusion Protein from an Infectious Salmon Anaemia Virus HPR0 Genotype Promote Viral Fusion and Activation by an Ubiquitous Host Protease.Roles of Ser101, Asp236, and His237 in catalysis of thioesterase II and of the C-terminal region of the enzyme in its interaction with fatty acid synthase.Unexpected trypsin cleavage at ubiquitinated lysines.Thrombin.Expression of virus-encoded proteinases: functional and structural similarities with cellular enzymesSoluble oligomers of the intramembrane serine protease YqgP are catalytically active in the absence of detergents.
P2860
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P2860
The three-dimensional structure of Asn102 mutant of trypsin: role of Asp102 in serine protease catalysis
description
1987 nî lūn-bûn
@nan
1987 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1987 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1987年の論文
@ja
1987年学术文章
@wuu
1987年学术文章
@zh-cn
1987年学术文章
@zh-hans
1987年学术文章
@zh-my
1987年学术文章
@zh-sg
1987年學術文章
@yue
name
The three-dimensional structur ...... 2 in serine protease catalysis
@ast
The three-dimensional structur ...... 2 in serine protease catalysis
@en
The three-dimensional structur ...... 2 in serine protease catalysis
@nl
type
label
The three-dimensional structur ...... 2 in serine protease catalysis
@ast
The three-dimensional structur ...... 2 in serine protease catalysis
@en
The three-dimensional structur ...... 2 in serine protease catalysis
@nl
prefLabel
The three-dimensional structur ...... 2 in serine protease catalysis
@ast
The three-dimensional structur ...... 2 in serine protease catalysis
@en
The three-dimensional structur ...... 2 in serine protease catalysis
@nl
P2093
P356
P1433
P1476
The three-dimensional structur ...... 2 in serine protease catalysis
@en
P2093
J Finer-Moore
R J Fletterick
R M Stroud
T Standing
W J Rutter
P356
10.1126/SCIENCE.3112942
P407
P577
1987-08-21T00:00:00Z