Crystal structures of Escherichia coli and Lactobacillus casei dihydrofolate reductase refined at 1.7 A resolution. I. General features and binding of methotrexate
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Structure and expression of human dihydropteridine reductaseThe relation between the divergence of sequence and structure in proteinsStructure and dynamics in solution of the complex of lactobacillus casei dihydrofolate reductase with the new lipophilic antifolate drug trimetrexateSynthetic and Crystallographic Studies of a New Inhibitor Series Targeting Bacillus anthracis Dihydrofolate ReductaseFunctional Role for the Conformationally Mobile Phenylalanine 223 in the Reaction of Methylenetetrahydrofolate Reductase from Escherichia coliA Disconnect between High-Affinity Binding and Efficient Regulation by Antifolates and Purines in the Tetrahydrofolate RiboswitchLong-range structural effects in a second-site revertant of a mutant dihydrofolate reductaseA link between protein structure and enzyme catalyzed hydrogen tunnelingStructural homologies with ATP- and folate-binding enzymes in the crystal structure of folylpolyglutamate synthetaseInterpretable correlation descriptors for quantitativestructure-activity relationshipsThree-dimensional structure of the bifunctional protein PCD/DCoH, a cytoplasmic enzyme interacting with transcription factor HNF1Conformational analysis of environmental agents: use of X-ray crystallographic data to determine molecular reactivityExperimental resolution of the free energies of aqueous solvation contributions to ligand-protein binding: quinone-QA site interactions in the photosynthetic reaction center proteinIdentifying residue-residue clashes in protein hybrids by using a second-order mean-field approach.Fluorescent biphenyl derivatives of phenylalanine suitable for protein modification.Automatic identification and representation of protein binding sites for molecular docking.The effect of denaturants on protein structure.Moritella cold-active dihydrofolate reductase: are there natural limits to optimization of catalytic efficiency at low temperature?NMR observation of individual molecules of hydration water bound to DNA duplexes: direct evidence for a spine of hydration water present in aqueous solution.Dynamics of trimethoprim bound to dihydrofolate reductase.Probing the salt bridge in the dihydrofolate reductase-methotrexate complex by using the coordinate-coupled free-energy perturbation methodFactors that cause trimethoprim resistance in Streptococcus pyogenes.Refolding of Escherichia coli dihydrofolate reductase: sequential formation of substrate binding sites.A free-energy perturbation study of the binding of methotrexate to mutants of dihydrofolate reductaseProtein fragments as probes in the study of protein folding mechanisms: differential effects of dihydrofolate reductase fragments on the refolding of the intact protein.Stopped-flow NMR spectroscopy: real-time unfolding studies of 6-19F-tryptophan-labeled Escherichia coli dihydrofolate reductase.Effects of fluorine substitution on the structure and dynamics of complexes of dihydrofolate reductase (Escherichia coli).pH-dependent conformational changes in Escherichia coli dihydrofolate reductase revealed by Raman difference spectroscopyCloning and characterization of a novel trimethoprim-resistant dihydrofolate reductase from a nosocomial isolate of Staphylococcus aureus CM.S2 (IMCJ1454).Characterization of dihydrofolate reductase genes from trimethoprim-susceptible and trimethoprim-resistant strains of Enterococcus faecalisStructural mimicry of adenosine by the antitumor agents 4-methoxy- and 4-amino-8-(beta-D-ribofuranosylamino)pyrimido[5,4-d]pyrimidine as viewed by a molecular modeling methodCrystal structures of Klebsiella pneumoniae dihydrofolate reductase bound to propargyl-linked antifolates reveal features for potency and selectivity.Structure of a partially unfolded form of Escherichia coli dihydrofolate reductase provides insight into its folding pathway.Tryptophan-based fluorophores for studying protein conformational changes.Identification of novel potential antibiotics against Staphylococcus using structure-based drug screening targeting dihydrofolate reductaseMutations in the dihydrofolate reductase gene of trimethoprim-resistant isolates of Streptococcus pneumoniaeNeutron diffraction studies of Escherichia coli dihydrofolate reductase complexed with methotrexate.Binding sites in Escherichia coli dihydrofolate reductase communicate by modulating the conformational ensembleAn essential intermediate in the folding of dihydrofolate reductase.Characterization of a novel bifunctional dihydropteroate synthase/dihydropteroate reductase enzyme from Helicobacter pylori
P2860
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P2860
Crystal structures of Escherichia coli and Lactobacillus casei dihydrofolate reductase refined at 1.7 A resolution. I. General features and binding of methotrexate
description
1982 nî lūn-bûn
@nan
1982 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1982 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1982年の論文
@ja
1982年学术文章
@wuu
1982年学术文章
@zh-cn
1982年学术文章
@zh-hans
1982年学术文章
@zh-my
1982年学术文章
@zh-sg
1982年學術文章
@yue
name
Crystal structures of Escheric ...... es and binding of methotrexate
@ast
Crystal structures of Escheric ...... es and binding of methotrexate
@en
Crystal structures of Escheric ...... es and binding of methotrexate
@nl
type
label
Crystal structures of Escheric ...... es and binding of methotrexate
@ast
Crystal structures of Escheric ...... es and binding of methotrexate
@en
Crystal structures of Escheric ...... es and binding of methotrexate
@nl
prefLabel
Crystal structures of Escheric ...... es and binding of methotrexate
@ast
Crystal structures of Escheric ...... es and binding of methotrexate
@en
Crystal structures of Escheric ...... es and binding of methotrexate
@nl
P2093
P1476
Crystal structures of Escheric ...... es and binding of methotrexate
@en
P2093
P304
13650-13662
P407
P577
1982-11-01T00:00:00Z