Crystal structure of the tetramerization domain of the p53 tumor suppressor at 1.7 angstroms
about
Expression of full-length p53 and its isoform Deltap53 in breast carcinomas in relation to mutation status and clinical parametersEffects of mutant p53 expression on human 15-lipoxygenase-promoter activity and murine 12/15-lipoxygenase gene expression: evidence that 15-lipoxygenase is a mutator genep73 and p63 are homotetramers capable of weak heterotypic interactions with each other but not with p53Charge modification at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm traffickingAn induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificityRegulation of p53 tetramerization and nuclear export by ARCAdenovirus E1B 55K represses p53 activation in vitro.A unified assembly mode revealed by the structures of tetrameric L27 domain complexes formed by mLin-2/mLin-7 and Patj/Pals1 scaffold proteinsp53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damageDNA damage in oocytes induces a switch of the quality control factor TAp63α from dimer to tetramerCytoplasmic p53 polypeptide is associated with ribosomesQuaternary structures of tumor suppressor p53 and a specific p53 DNA complexModulation of p53 activity by IkappaBalpha: evidence suggesting a common phylogeny between NF-kappaB and p53 transcription factors.Traditional biomolecular structure determination by NMR spectroscopy allows for major errors.Crystal structure of the mouse p53 core DNA-binding domain at 2.7 A resolutionStructural evolution of C-terminal domains in the p53 familyImpact of low-frequency hotspot mutation R282Q on the structure of p53 DNA-binding domain as revealed by crystallography at 1.54 Å resolutionCrystal structure of a p53 core tetramer bound to DNAStructural evolution of p53, p63, and p73: Implication for heterotetramer formationInteraction of the p53 DNA-Binding Domain with Its N-Terminal Extension Modulates the Stability of the p53 TetramerStructure and Kinetic Stability of the p63 Tetramerization DomainThe rebel angel: mutant p53 as the driving oncogene in breast cancer.Physical interaction and functional antagonism between the RNA polymerase II elongation factor ELL and p53Specific recognition of p53 tetramers by peptides derived from p53 interacting proteinsA role for Groucho tetramerization in transcriptional repressionTracing the evolution of the p53 tetramerization domainAn Integrated Mass Spectrometry Based Approach to Probe the Structure of the Full-Length Wild-Type Tetrameric p53 Tumor Suppressor.Evolutionary conservation and somatic mutation hotspot maps of p53: correlation with p53 protein structural and functional features.Disease mutations in RUNX1 and RUNX2 create nonfunctional, dominant-negative, or hypomorphic alleles.Integrating mutation data and structural analysis of the TP53 tumor-suppressor protein.In vitro evolution of thermostable p53 variantsFactors governing loss and rescue of DNA binding upon single and double mutations in the p53 core domain.Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors.Flexible nets: disorder and induced fit in the associations of p53 and 14-3-3 with their partners.Noncanonical DNA motifs as transactivation targets by wild type and mutant p53Conservation of DNA-binding specificity and oligomerisation properties within the p53 family.Involvement of miR-605 and miR-34a in the DNA damage response promotes apoptosis induction.p53 binding to nucleosomal DNA depends on the rotational positioning of DNA response element.The emerging p53 gene family.Interplay between Mdm2 and HIPK2 in the DNA damage response.
P2860
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P2860
Crystal structure of the tetramerization domain of the p53 tumor suppressor at 1.7 angstroms
description
1995 nî lūn-bûn
@nan
1995 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի մարտին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Crystal structure of the tetra ...... or suppressor at 1.7 angstroms
@ast
Crystal structure of the tetra ...... or suppressor at 1.7 angstroms
@en
Crystal structure of the tetra ...... or suppressor at 1.7 angstroms
@nl
type
label
Crystal structure of the tetra ...... or suppressor at 1.7 angstroms
@ast
Crystal structure of the tetra ...... or suppressor at 1.7 angstroms
@en
Crystal structure of the tetra ...... or suppressor at 1.7 angstroms
@nl
prefLabel
Crystal structure of the tetra ...... or suppressor at 1.7 angstroms
@ast
Crystal structure of the tetra ...... or suppressor at 1.7 angstroms
@en
Crystal structure of the tetra ...... or suppressor at 1.7 angstroms
@nl
P2093
P2860
P3181
P356
P1433
P1476
Crystal structure of the tetra ...... or suppressor at 1.7 angstroms
@en
P2093
N P Pavletich
P D Jeffrey
P2860
P304
P3181
P356
10.1126/SCIENCE.7878469
P407
P577
1995-03-10T00:00:00Z