An anion binding site in human aldose reductase: mechanistic implications for the binding of citrate, cacodylate, and glucose 6-phosphate
about
Molecular cloning, expression and catalytic activity of a human AKR7 member of the aldo-keto reductase superfamily: evidence that the major 2-carboxybenzaldehyde reductase from human liver is a homologue of rat aflatoxin B1-aldehyde reductaseSelective serotonin reuptake inhibitors directly alter activity of neurosteroidogenic enzymesCrystal structure of CHO reductase, a member of the aldo-keto reductase superfamilyThe crystal structure of rat liver AKR7A1. A dimeric member of the aldo-keto reductase superfamilyCrystal structures of F420-dependent glucose-6-phosphate dehydrogenase FGD1 involved in the activation of the anti-tuberculosis drug candidate PA-824 reveal the basis of coenzyme and substrate bindingStructure of aldose reductase from Giardia lambliaA conformational landscape for alginate secretion across the outer membrane ofPseudomonas aeruginosaIdentification of a novel polyfluorinated compound as a lead to inhibit the human enzymes aldose reductase and AKR1B10: structure determination of both ternary complexes and implications for drug designComparative anatomy of the aldo-keto reductase superfamilyAFAP-120. A variant form of the Src SH2/SH3-binding partner AFAP-110 is detected in brain and contains a novel internal sequence which binds to a 67-kDa protein.Molecular modeling of substrate binding in wild-type and mutant Corynebacteria 2,5-diketo-D-gluconate reductases.THEMATICS: a simple computational predictor of enzyme function from structureNovel role for aldose reductase in mediating acute inflammatory responses in the lung.Structural and thermodynamic studies of simple aldose reductase-inhibitor complexes.Aldose reductase participates in the downregulation of T cell functions due to suppressor macrophages.Human aldo-keto reductases: structure, substrate specificity and roles in tumorigenesis.Metabolism-induced oxidative stress is a mediator of glucose toxicity in HT22 neuronal cells.Identification of cardiac oxidoreductase(s) involved in the metabolism of the lipid peroxidation-derived aldehyde-4-hydroxynonenalIdentification of amino acid residues responsible for differences in substrate specificity and inhibitor sensitivity between two human liver dihydrodiol dehydrogenase isoenzymes by site-directed mutagenesisKinetic alteration of a human dihydrodiol/3alpha-hydroxysteroid dehydrogenase isoenzyme, AKR1C4, by replacement of histidine-216 with tyrosine or phenylalanine.Roles of the C-terminal domains of human dihydrodiol dehydrogenase isoforms in the binding of substrates and modulators: probing with chimaeric enzymes.Sequence of the cDNA of a human dihydrodiol dehydrogenase isoform (AKR1C2) and tissue distribution of its mRNA.Involvement of two basic residues (Lys-270 and Arg-276) of human liver 3 alpha-hydroxysteroid dehydrogenase in NADP(H) binding and activation by sulphobromophthalein: site-directed mutagenesis and kinetic analysis.Activation of human liver 3 alpha-hydroxysteroid dehydrogenase by sulphobromophthalein.Invariant glycines and prolines flanking in loops the strand beta 2 of various (alpha/beta)8-barrel enzymes: a hidden homology?Crystal structure of an aldehyde reductase Y50F mutant-NADP complex and its implications for substrate binding.Active site prediction for comparative model structures with thematics.Kinetic and molecular docking studies of loganin and 7-O-galloyl-D-sedoheptulose from Corni Fructus as therapeutic agents for diabetic complications through inhibition of aldose reductase.The aldo-keto reductase superfamily and its role in drug metabolism and detoxification
P2860
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P2860
An anion binding site in human aldose reductase: mechanistic implications for the binding of citrate, cacodylate, and glucose 6-phosphate
description
1994 nî lūn-bûn
@nan
1994 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի մարտին հրատարակված գիտական հոդված
@hy
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
name
An anion binding site in human ...... ylate, and glucose 6-phosphate
@ast
An anion binding site in human ...... ylate, and glucose 6-phosphate
@en
An anion binding site in human ...... ylate, and glucose 6-phosphate
@nl
type
label
An anion binding site in human ...... ylate, and glucose 6-phosphate
@ast
An anion binding site in human ...... ylate, and glucose 6-phosphate
@en
An anion binding site in human ...... ylate, and glucose 6-phosphate
@nl
prefLabel
An anion binding site in human ...... ylate, and glucose 6-phosphate
@ast
An anion binding site in human ...... ylate, and glucose 6-phosphate
@en
An anion binding site in human ...... ylate, and glucose 6-phosphate
@nl
P2093
P356
P1433
P1476
An anion binding site in human ...... ylate, and glucose 6-phosphate
@en
P2093
D H Harrison
K H Gabbay
K M Bohren
P304
P356
10.1021/BI00174A006
P407
P577
1994-03-01T00:00:00Z