A catalytically-impaired class A beta-lactamase: 2 A crystal structure and kinetics of the Bacillus licheniformis E166A mutant
about
Three decades of beta-lactamase inhibitorsAcyl-intermediate structures of the extended-spectrum class A beta-lactamase, Toho-1, in complex with cefotaxime, cephalothin, and benzylpenicillinRoles of amino acids 161 to 179 in the PSE-4 omega loop in substrate specificity and in resistance to ceftazidimeDifferent intermediate populations formed by tazobactam, sulbactam, and clavulanate reacting with SHV-1 beta-lactamases: Raman crystallographic evidenceCloning and sequencing of the gene encoding Toho-2, a class A beta-lactamase preferentially inhibited by tazobactamSHV-16, a beta-lactamase with a pentapeptide duplication in the omega loop.Extended-spectrum and inhibitor-resistant TEM-type beta-lactamases: mutations, specificity, and three-dimensional structure.Characterization of a new TEM-derived beta-lactamase produced in a Serratia marcescens strainpKa calculations for class A beta-lactamases: influence of substrate binding.Evidence for myosin motors on organelles in squid axoplasm.Evolution of an enzyme activity: crystallographic structure at 2-A resolution of cephalosporinase from the ampC gene of Enterobacter cloacae P99 and comparison with a class A penicillinase.Mutation of the active site carboxy-lysine (K70) of OXA-1 beta-lactamase results in a deacylation-deficient enzyme.Active-Site Protonation States in an Acyl-Enzyme Intermediate of a Class A β-Lactamase with a Monobactam SubstrateSubstitution of Asp for Asn at position 132 in the active site of TEM beta-lactamase. Activity toward different substrates and effects of neighboring residues.Site-directed mutagenesis of beta-lactamase I: role of Glu-166.pKa calculations for class A beta-lactamases: methodological and mechanistic implications.Role of residues 104, 164, 166, 238 and 240 in the substrate profile of PER-1 beta-lactamase hydrolysing third-generation cephalosporins.pKa, MM, and QM studies of mechanisms of beta-lactamases and penicillin-binding proteins: acylation step.A QM/MM study on the enzymatic inactivation of cefotaxime.Effects on substrate profile by mutational substitutions at positions 164 and 179 of the class A TEM(pUC19) beta-lactamase from Escherichia coli.A new TEM beta-lactamase double mutant with broadened specificity reveals substrate-dependent functional interactions.
P2860
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P2860
A catalytically-impaired class A beta-lactamase: 2 A crystal structure and kinetics of the Bacillus licheniformis E166A mutant
description
1993 nî lūn-bûn
@nan
1993 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
name
A catalytically-impaired class ...... lus licheniformis E166A mutant
@ast
A catalytically-impaired class ...... lus licheniformis E166A mutant
@en
A catalytically-impaired class ...... lus licheniformis E166A mutant
@nl
type
label
A catalytically-impaired class ...... lus licheniformis E166A mutant
@ast
A catalytically-impaired class ...... lus licheniformis E166A mutant
@en
A catalytically-impaired class ...... lus licheniformis E166A mutant
@nl
prefLabel
A catalytically-impaired class ...... lus licheniformis E166A mutant
@ast
A catalytically-impaired class ...... lus licheniformis E166A mutant
@en
A catalytically-impaired class ...... lus licheniformis E166A mutant
@nl
P2093
P356
P1476
A catalytically-impaired class ...... lus licheniformis E166A mutant
@en
P2093
P356
10.1093/PROTEIN/6.1.11
P577
1993-01-01T00:00:00Z