Effects on substrate profile by mutational substitutions at positions 164 and 179 of the class A TEM(pUC19) beta-lactamase from Escherichia coli.
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Quantifying the adaptive potential of an antibiotic resistance enzymeAcyl-intermediate structures of the extended-spectrum class A beta-lactamase, Toho-1, in complex with cefotaxime, cephalothin, and benzylpenicillinA triple mutant in the Ω-loop of TEM-1 β-lactamase changes the substrate profile via a large conformational change and an altered general base for catalysisExploring the role of a conserved class A residue in the Ω-Loop of KPC-2 β-lactamase: a mechanism for ceftazidime hydrolysisNetwork models of TEM β-lactamase mutations coevolving under antibiotic selection show modular structure and anticipate evolutionary trajectoriesCrystal structure and activity studies of the Mycobacterium tuberculosis beta-lactamase reveal its critical role in resistance to beta-lactam antibioticsNovel ceftazidime-resistance beta-lactamases generated by a codon-based mutagenesis method and selection.One-step random mutagenesis by error-prone rolling circle amplification.Error-prone rolling circle amplification: the simplest random mutagenesis protocol.SHV-16, a beta-lactamase with a pentapeptide duplication in the omega loop.CTX-M-type extended-spectrum beta-lactamase that hydrolyzes ceftazidime through a single amino acid substitution in the omega loopUnexpected enzyme TEM-126: role of mutation Asp179GluTwelve positions in a β-lactamase that can expand its substrate spectrum with a single amino acid substitution.An analysis of why highly similar enzymes evolve differentlyRole of Asp104 in the SHV beta-lactamase.Role of pleiotropy during adaptation of TEM-1 β-lactamase to two novel antibiotics.A new TEM-derived extended-spectrum beta-lactamase (TEM-91) with an R164C substitution at the omega-loop confers ceftazidime resistanceActivity of ceftazidime/avibactam against isogenic strains of Escherichia coli containing KPC and SHV β-lactamases with single amino acid substitutions in the Ω-loop.Exposing a β-Lactamase "Twist": the Mechanistic Basis for the High Level of Ceftazidime Resistance in the C69F Variant of the Burkholderia pseudomallei PenI β-Lactamase.Role of a mutation at position 167 of CTX-M-19 in ceftazidime hydrolysis.Natural evolution of TEM-1 β-lactamase: experimental reconstruction and clinical relevance.Mutant TEM beta-lactamase producing resistance to ceftazidime, ampicillins, and beta-lactamase inhibitors.Haemophilus influenzae bla(ROB-1) mutations in hypermutagenic deltaampC Escherichia coli conferring resistance to cefotaxime and beta-lactamase inhibitors and increased susceptibility to cefaclorMechanistic basis for the emergence of catalytic competence against carbapenem antibiotics by the GES family of beta-lactamases.Conserved water molecules stabilize the Omega-loop in class A beta-lactamasesMultiple molecular dynamics simulations of TEM beta-lactamase: dynamics and water binding of the omega-loop.Negative Epistasis and Evolvability in TEM-1 β-Lactamase--The Thin Line between an Enzyme's Conformational Freedom and Disorder.Klebsiella pneumoniae Carbapenemase-2 (KPC-2), Substitutions at Ambler Position Asp179, and Resistance to Ceftazidime-Avibactam: Unique Antibiotic-Resistant Phenotypes Emerge from β-Lactamase Protein Engineering.A Tyrosine Residue Along with a Glutamic Acid of the Omega-Like Loop Governs the Beta-Lactamase Activity of MSMEG_4455 in Mycobacterium smegmatis.Structural and Mechanistic Basis for Extended-Spectrum Drug-Resistance Mutations in Altering the Specificity of TEM, CTX-M, and KPC β-lactamases.NMR investigation of Tyr105 mutants in TEM-1 beta-lactamase: dynamics are correlated with function.
P2860
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P2860
Effects on substrate profile by mutational substitutions at positions 164 and 179 of the class A TEM(pUC19) beta-lactamase from Escherichia coli.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh-hant
name
Effects on substrate profile b ...... 164 and 179 of the class A TEM
@nl
Effects on substrate profile b ...... ctamase from Escherichia coli.
@en
type
label
Effects on substrate profile b ...... 164 and 179 of the class A TEM
@nl
Effects on substrate profile b ...... ctamase from Escherichia coli.
@en
prefLabel
Effects on substrate profile b ...... 164 and 179 of the class A TEM
@nl
Effects on substrate profile b ...... ctamase from Escherichia coli.
@en
P2093
P2860
P356
P1476
Effects on substrate profile b ...... ctamase from Escherichia coli.
@en
P2093
Mobashery S
Taibi-Tronche P
Vakulenko SB
P2860
P304
23052-23060
P356
10.1074/JBC.274.33.23052
P407
P577
1999-08-01T00:00:00Z