A new TEM beta-lactamase double mutant with broadened specificity reveals substrate-dependent functional interactions.
about
X-ray analysis of the NMC-A beta-lactamase at 1.64-A resolution, a class A carbapenemase with broad substrate specificityRoles of amino acids 161 to 179 in the PSE-4 omega loop in substrate specificity and in resistance to ceftazidimeSaturation mutagenesis of Asn152 reveals a substrate selectivity switch in P99 cephalosporinaseCharacterization of TEM-56, a novel beta-lactamase produced by a Klebsiella pneumoniae clinical isolateA secondary drug resistance mutation of TEM-1 beta-lactamase that suppresses misfolding and aggregation.Protonation of the beta-lactam nitrogen is the trigger event in the catalytic action of class A beta-lactamasesExtended-spectrum and inhibitor-resistant TEM-type beta-lactamases: mutations, specificity, and three-dimensional structure.Characterization of a new TEM-derived beta-lactamase produced in a Serratia marcescens strainRole of Asp104 in the SHV beta-lactamase.High tolerance to simultaneous active-site mutations in TEM-1 beta-lactamase: Distinct mutational paths provide more generalized beta-lactam recognitionStructural and Mechanistic Basis for Extended-Spectrum Drug-Resistance Mutations in Altering the Specificity of TEM, CTX-M, and KPC β-lactamases.
P2860
Q27765392-059A6AF2-7993-4AAA-92A2-98DCEC9F043FQ32012271-38156C88-0423-468B-86E1-D32C0C6C62E1Q33306655-FAAAB774-EA71-4EE3-8F30-9307168227FBQ33978835-1CFB105A-5E1B-4C95-9CDB-63FC3A7CB2CEQ34594475-087EB267-B28A-410E-85AE-E0B69EF9D34EQ35107180-59BC5FBE-3BA4-41D9-A6D0-5E7835559BD7Q35120519-6ADC2987-22BB-4814-85F1-90FA692D6A28Q35138799-DF1349F0-979C-418F-97E9-B57236C64F1AQ35215422-48B41EA9-7C7D-451F-8CFB-AC80B83F78BEQ37255412-66CFCDD6-EDF4-4725-9B7B-A07E4AE06451Q52661545-59380CD7-C997-4632-824D-436AD76F0F3A
P2860
A new TEM beta-lactamase double mutant with broadened specificity reveals substrate-dependent functional interactions.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年学术文章
@wuu
1995年学术文章
@zh-cn
1995年学术文章
@zh-hans
1995年学术文章
@zh-my
1995年学术文章
@zh-sg
1995年學術文章
@yue
1995年學術文章
@zh
1995年學術文章
@zh-hant
name
A new TEM beta-lactamase doubl ...... ndent functional interactions.
@en
A new TEM beta-lactamase doubl ...... ndent functional interactions.
@nl
type
label
A new TEM beta-lactamase doubl ...... ndent functional interactions.
@en
A new TEM beta-lactamase doubl ...... ndent functional interactions.
@nl
prefLabel
A new TEM beta-lactamase doubl ...... ndent functional interactions.
@en
A new TEM beta-lactamase doubl ...... ndent functional interactions.
@nl
P2093
P2860
P356
P1476
A new TEM beta-lactamase doubl ...... ndent functional interactions.
@en
P2093
P2860
P304
P356
10.1074/JBC.270.2.775
P407
P577
1995-01-01T00:00:00Z