Crystal structure of an elastase-specific inhibitor elafin complexed with porcine pancreatic elastase determined at 1.9 A resolution
about
The trappin gene family: proteins defined by an N-terminal transglutaminase substrate domain and a C-terminal four-disulphide coreA locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic proteinThe structure of the human betaII-tryptase tetramer: fo(u)r better or worseThe evolution of a genetic locus encoding small serine proteinase inhibitorsPredicting binding sites of hydrolase-inhibitor complexes by combining several methodsStructure of porcine pancreatic elastase complexed with FR901277, a novel macrocyclic inhibitor of elastases, at 1.6 A resolutionComplexation of two proteic insect inhibitors to the active site of chymotrypsin suggests decoupled roles for binding and selectivityStaphylococcus aureus secretes a unique class of neutrophil serine protease inhibitorsIdentification of a novel family of proteins in snake venoms. Purification and structural characterization of nawaprin from Naja nigricollis snake venomComplex of human neutrophil elastase with 1/2SLPIMolecular modelling and experimental studies of mutation and cell-adhesion sites in the fibronectin type III and whey acidic protein domains of human anosmin-1Molecular cloning and expression of ps20 growth inhibitor. A novel WAP-type "four-disulfide core" domain protein expressed in smooth muscleBioinformatic screening of autoimmune disease genes and protein structure prediction with FAMS for drug discoverySelection of human elastase inhibitors from a conformationally constrained combinatorial peptide library.Design, docking, and evaluation of multiple libraries against multiple targets.Design, synthesis and evaluation of biomimetic affinity ligands for elastases.Structural and antimicrobial properties of human pre-elafin/trappin-2 and derived peptides against Pseudomonas aeruginosa.Targeted overexpression of elafin protects mice against cardiac dysfunction and mortality following viral myocarditisIdentification of interface residues in protease-inhibitor and antigen-antibody complexes: a support vector machine approach.Neutrophil elastase, proteinase 3, and cathepsin G as therapeutic targets in human diseases.Trappin-2/elafin modulate innate immune responses of human endometrial epithelial cells to PolyI:CMolecular cloning and characterization of lustrin A, a matrix protein from shell and pearl nacre of Haliotis rufescens.Anti-HIV-1 activity of elafin depends on its nuclear localization and altered innate immune activation in female genital epithelial cells.Anti-HIV-1 activity of elafin is more potent than its precursor's, trappin-2, in genital epithelial cellsFunctional study of elafin cleaved by Pseudomonas aeruginosa metalloproteinases.Elafin, an elastase-specific inhibitor, is cleaved by its cognate enzyme neutrophil elastase in sputum from individuals with cystic fibrosisAntiviral activity of trappin-2 and elafin in vitro and in vivo against genital herpes.Elafin is specifically inactivated by RgpB from Porphyromonas gingivalis by distinct proteolytic cleavage.Therapeutic potential of human elafin.Privileged frameworks from snake venom.Inhibitors and Antibody Fragments as Potential Anti-Inflammatory Therapeutics Targeting Neutrophil Proteinase 3 in Human Disease.En route towards the peptide γ-helix: X-ray diffraction analyses and conformational energy calculations of Adm-rich short peptides.Cross-talk of anosmin-1, the protein implicated in X-linked Kallmann's syndrome, with heparan sulphate and urokinase-type plasminogen activator.Three-dimensional Structure of a Kunitz-type Inhibitor in Complex with an Elastase-like Enzyme.A role for whey acidic protein four-disulfide-core 12 (WFDC12) in the regulation of the inflammatory response in the lung.Stabilization of porcine pancreatic elastase crystals by glutaraldehyde cross-linking.Cathepsin-L and transglutaminase dependent processing of ps20: A novel mechanism for ps20 regulation via ECM cross-linking.Elafin in pulmonary arterial hypertension. Beyond targeting elastases.Characterization of human pre-elafin mutants: full antipeptidase activity is essential to preserve lung tissue integrity in experimental emphysema.Androgen-dependent expression, gene structure, and molecular evolution of guinea pig caltrin II, a WAP-motif protein.
P2860
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P2860
Crystal structure of an elastase-specific inhibitor elafin complexed with porcine pancreatic elastase determined at 1.9 A resolution
description
1996 nî lūn-bûn
@nan
1996 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
Crystal structure of an elasta ...... determined at 1.9 A resolution
@ast
Crystal structure of an elasta ...... determined at 1.9 A resolution
@en
Crystal structure of an elasta ...... determined at 1.9 A resolution
@nl
type
label
Crystal structure of an elasta ...... determined at 1.9 A resolution
@ast
Crystal structure of an elasta ...... determined at 1.9 A resolution
@en
Crystal structure of an elasta ...... determined at 1.9 A resolution
@nl
prefLabel
Crystal structure of an elasta ...... determined at 1.9 A resolution
@ast
Crystal structure of an elasta ...... determined at 1.9 A resolution
@en
Crystal structure of an elasta ...... determined at 1.9 A resolution
@nl
P2093
P356
P1433
P1476
Crystal structure of an elasta ...... determined at 1.9 A resolution
@en
P2093
S Sakakibara
Y Matsuura
P304
P356
10.1021/BI960900L
P407
P577
1996-09-10T00:00:00Z