X-ray structure of active site-inhibited clotting factor Xa. Implications for drug design and substrate recognition
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Structure of tick anticoagulant peptide at 1.6 A resolution complexed with bovine pancreatic trypsin inhibitorRational approaches to improving selectivity in drug designStructure of human factor VIIa and its implications for the triggering of blood coagulation(R)-3-Amidinophenylalanine-derived inhibitors of factor Xa with a novel active-site binding modeThe discovery of (2R,4R)-N-(4-chlorophenyl)-N- (2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl)-4-methoxypyrrolidine-1,2-dicarboxamide (PD 0348292), an orally efficacious factor Xa inhibitorThe Tick-Derived Anticoagulant Madanin Is Processed by Thrombin and Factor XaStructural basis for dual inhibitory role of tamarind Kunitz inhibitor (TKI) against factor Xa and trypsinThe three-dimensional structure of recombinant leech-derived tryptase inhibitor in complex with trypsin. Implications for the structure of human mast cell tryptase and its inhibitionStructural mapping of the active site specificity determinants of human tissue-type plasminogen activator. Implications for the design of low molecular weight substrates and inhibitorsStructural basis for chemical inhibition of human blood coagulation factor XaNew enzyme lineages by subdomain shufflingProbing the interface between factor Xa and tissue factor in the quaternary complex tissue factor-factor VIIa-factor Xa-tissue factor pathway inhibitorExosite-driven substrate specificity and function in coagulationCharacterization of structural determinants of granzyme B reveals potent mediators of extended substrate specificityA unique substrate recognition profile for matrix metalloproteinase-2.Rapid and general profiling of protease specificity by using combinatorial fluorogenic substrate librariesMapping the active site of factor Xa by selective inhibitors: an NMR and MD study.Approaches to selective peptidic inhibitors of factor Xa.Molecular docking screens using comparative models of proteinsAn anticoagulant RNA aptamer that inhibits proteinase-cofactor interactions within prothrombinaseStructural and energetic determinants of the S1-site specificity in serine proteases.Small, noncovalent serine protease inhibitors.Coagulation factor Xa: the prothrombinase complex as an emerging therapeutic target for small molecule inhibitors.Heparin enhances the specificity of antithrombin for thrombin and factor Xa independent of the reactive center loop sequence. Evidence for an exosite determinant of factor Xa specificity in heparin-activated antithrombin.Factor Xa subsite mapping by proteome-derived peptide libraries improved using WebPICS, a resource for proteomic identification of cleavage sites.Structure and dynamics of zymogen human blood coagulation factor XRole of the active-site solvent in the thermodynamics of factor Xa ligand binding.The structure of thrombin, a chameleon-like proteinase.Factor Xa active site substrate specificity with substrate phage display and computational molecular modeling.Deuterium solvent isotope effect and proton-inventory studies of factor Xa-catalyzed reactionsMolecular dynamics simulations of Factor Xa: insight into conformational transition of its binding subsites.Cloning and comparison of factor X from rhesus monkey (Macaca mulatta)Activation mechanisms of coagulation factor IX.Developments in factor Xa inhibitors for the treatment of thromboembolic disorders.Directed glycosylation of human coagulation factor X at residue 333. Insight into factor Va-dependent prothrombin catalysis.Physiological fIXa activation involves a cooperative conformational rearrangement of the 99-loop.Insight into the molecular mechanism of P-glycoprotein mediated drug toxicity induced by bioflavonoids: an integrated computational approach.Protease Inhibitors in View of Peptide Substrate Databases.Trypsin mutants for structure-based drug design: expression, refolding and crystallisation.Prothrombinase assembly and S1 site occupation restore the catalytic activity of FXa impaired by mutation at the sodium-binding site.
P2860
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P2860
X-ray structure of active site-inhibited clotting factor Xa. Implications for drug design and substrate recognition
description
1996 nî lūn-bûn
@nan
1996 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年学术文章
@wuu
1996年学术文章
@zh-cn
1996年学术文章
@zh-hans
1996年学术文章
@zh-my
1996年学术文章
@zh-sg
1996年學術文章
@yue
name
X-ray structure of active site ...... sign and substrate recognition
@ast
X-ray structure of active site ...... sign and substrate recognition
@en
X-ray structure of active site ...... sign and substrate recognition
@nl
type
label
X-ray structure of active site ...... sign and substrate recognition
@ast
X-ray structure of active site ...... sign and substrate recognition
@en
X-ray structure of active site ...... sign and substrate recognition
@nl
prefLabel
X-ray structure of active site ...... sign and substrate recognition
@ast
X-ray structure of active site ...... sign and substrate recognition
@en
X-ray structure of active site ...... sign and substrate recognition
@nl
P2093
P2860
P3181
P356
P1476
X-ray structure of active site ...... sign and substrate recognition
@en
P2093
H Brandstetter
K Wirthensohn
W von der Saal
P2860
P304
P3181
P356
10.1074/JBC.271.47.29988
P407
P577
1996-11-22T00:00:00Z