Rapid and general profiling of protease specificity by using combinatorial fluorogenic substrate libraries
about
Substrate profiling of tobacco etch virus protease using a novel fluorescence-assisted whole-cell assayCatalytic properties and inhibition of proline-specific dipeptidyl peptidases II, IV and VIIHuman recombinant endopeptidase PHEX has a strict S1' specificity for acidic residues and cleaves peptides derived from fibroblast growth factor-23 and matrix extracellular phosphoglycoproteinProtease-activated receptor-4 uses dual prolines and an anionic retention motif for thrombin recognition and cleavageCleavage of eukaryotic translation initiation factor 4GII within foot-and-mouth disease virus-infected cells: identification of the L-protease cleavage site in vitroA constitutively active and uninhibitable caspase-3 zymogen efficiently induces apoptosisGlobal mapping of the topography and magnitude of proteolytic events in apoptosisProfiling constitutive proteolytic events in vivoDesigning ECM-mimetic materials using protein engineeringMicrofluidics and coagulation biologyVinyl Sulfones as Antiparasitic Agents and a Structural Basis for Drug DesignSubstrate Modulation of Enzyme Activity in the Herpesvirus Protease FamilyActive site conformational changes of prostasin provide a new mechanism of protease regulation by divalent cationsNonpeptidic Tetrafluorophenoxymethyl Ketone Cruzain Inhibitors as Promising New Leads for Chagas Disease ChemotherapyPeptide Length and Leaving-Group Sterics Influence Potency of Peptide Phosphonate Protease InhibitorsBroad-Spectrum Allosteric Inhibition of Herpesvirus ProteasesSpecificity profiling of seven human tissue kallikreins reveals individual subsite preferencesGranzyme M is a regulatory protease that inactivates proteinase inhibitor 9, an endogenous inhibitor of granzyme BThe emerging roles of human tissue kallikreins in cancerGlobal substrate profiling of proteases in human neutrophil extracellular traps reveals consensus motif predominantly contributed by elastaseSubstrate-driven mapping of the degradome by comparison of sequence logosCharacterizing Protease Specificity: How Many Substrates Do We Need?Inhibition of spinal microglial cathepsin S for the reversal of neuropathic painRat mast cell protease 4 is a beta-chymase with unusually stringent substrate recognition profileCharacterization of structural determinants of granzyme B reveals potent mediators of extended substrate specificityMutational tail loss is an evolutionary mechanism for liberating marapsins and other type I serine proteases from transmembrane anchors.Definition of the extended substrate specificity determinants for beta-tryptases I and II.A unique substrate recognition profile for matrix metalloproteinase-2.Cercarial elastase is encoded by a functionally conserved gene family across multiple species of schistosomes.Thrombin induces broad spectrum proteolysis in human serum samples.Advances in the use of synthetic combinatorial chemistry: mixture-based libraries.Aminopeptidase fingerprints, an integrated approach for identification of good substrates and optimal inhibitors.Printing chemical libraries on microarrays for fluid phase nanoliter reactions.Global analysis of proteasomal substrate specificity using positional-scanning libraries of covalent inhibitors.Rapid determination of substrate specificity of Clostridium histolyticum beta-collagenase using an immobilized peptide library.Altered substrate specificity of drug-resistant human immunodeficiency virus type 1 protease.Substrate specificity of human kallikrein 2 (hK2) as determined by phage display technology.Critical role of amino acid 23 in mediating activity and specificity of vinckepain-2, a papain-family cysteine protease of rodent malaria parasites.Phage display substrate: a blind method for determining protease specificity.Albumin is a substrate of human chymase. Prediction by combinatorial peptide screening and development of a selective inhibitor based on the albumin cleavage site.
P2860
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P2860
Rapid and general profiling of protease specificity by using combinatorial fluorogenic substrate libraries
description
2000 nî lūn-bûn
@nan
2000 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Rapid and general profiling of ...... luorogenic substrate libraries
@ast
Rapid and general profiling of ...... luorogenic substrate libraries
@en
type
label
Rapid and general profiling of ...... luorogenic substrate libraries
@ast
Rapid and general profiling of ...... luorogenic substrate libraries
@en
prefLabel
Rapid and general profiling of ...... luorogenic substrate libraries
@ast
Rapid and general profiling of ...... luorogenic substrate libraries
@en
P2093
P2860
P356
P1476
Rapid and general profiling of ...... luorogenic substrate libraries
@en
P2093
P2860
P304
P356
10.1073/PNAS.140132697
P407
P577
2000-07-01T00:00:00Z