A structural basis for recognition of A.T and T.A base pairs in the minor groove of B-DNA
about
A sequence-specific DNA binding small molecule triggers the release of immunogenic signals and phagocytosis in a model of B-cell lymphomaDNA minor groove recognition of a non-self-complementary AT-rich sequence by a tris-benzimidazole ligandBinding of AR-1-144, a tri-imidazole DNA minor groove binder, to CCGG sequence analyzed by NMR spectroscopyTATA element recognition by the TATA box-binding protein has been conserved throughout evolutionA Bulky Rhodium Complex Bound to an Adenosine-Adenosine DNA Mismatch: General Architecture of the Metalloinsertion Binding ModeAllosteric modulation of DNA by small moleculesStructural Basis for Cyclic Py-Im Polyamide Allosteric Inhibition of Nuclear Receptor BindingSignificance of ligand tails for interaction with the minor groove of B-DNAMinimization of a protein-DNA dimerizerChemical approaches to control gene expression.Use of fluorescent sequence-specific polyamides to discriminate human chromosomes by microscopy and flow cytometry.Next generation hairpin polyamides with (R)-3,4-diaminobutyric acid turn unit.Quantitating the concentration of Py-Im polyamide-fluorescein conjugates in live cellsCompletion of a Programmable DNA-Binding Small Molecule LibrarySequence-specific positions of water molecules at the interface between DNA and minor groove binders.Accelerated photobleaching of a cyanine dye in the presence of a ternary target DNA, PNA probe, dye catalytic complex: a molecular diagnosticBinding studies of a large antiviral polyamide to a natural HPV sequence.Bacterial promoter architecture: subsite structure of UP elements and interactions with the carboxy-terminal domain of the RNA polymerase alpha subunit.DNase protection analysis of retrovirus integrase at the viral DNA ends for full-site integration in vitro.DNA sequence recognition in the minor groove by crosslinked polyamides: The effect of N-terminal head group and linker length on binding affinity and specificityThermodynamic and kinetic analyses for understanding sequence-specific DNA recognition.Drug-DNA recognition: energetics and implications for design.Strong minor groove base conservation in sequence logos implies DNA distortion or base flipping during replication and transcription initiation.A C-14 labeled Py-Im polyamide localizes to a subcutaneous prostate cancer tumor.Knowledge-based elastic potentials for docking drugs or proteins with nucleic acidsAllosteric analysis of glucocorticoid receptor-DNA interface induced by cyclic Py-Im polyamide: a molecular dynamics simulation study.Defining the sequence-recognition profile of DNA-binding molecules.Tumor xenograft uptake of a pyrrole-imidazole (Py-Im) polyamide varies as a function of cell line grafted.Synthesis of cyclic Py-Im polyamide libraries.Structure-based DNA-targeting strategies with small molecule ligands for drug discovery.Inhibition of human papilloma virus E2 DNA binding protein by covalently linked polyamides.Design of sequence-specific DNA binding molecules for DNA methyltransferase inhibition.Toward rules for 1:1 polyamide:DNA recognitionProgrammable oligomers targeting 5'-GGGG-3' in the minor groove of DNA and NF-kappaB binding inhibition.Modulation of NF-κB-dependent gene transcription using programmable DNA minor groove bindersTumor Repression of VCaP Xenografts by a Pyrrole-Imidazole Polyamide.Pharmacokinetics of Py-Im polyamides depend on architecture: cyclic versus linear.The double-stranded-RNA-binding motif: interference and much more.hsDNA groove binding, photocatalytic activity, and in vitro breast and colon cancer cell reducing function of greener SeNPs.Single-dose pharmacokinetic and toxicity analysis of pyrrole-imidazole polyamides in mice.
P2860
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P2860
A structural basis for recognition of A.T and T.A base pairs in the minor groove of B-DNA
description
1998 nî lūn-bûn
@nan
1998 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
A structural basis for recognition of A.T and T.A base pairs in the minor groove of B-DNA
@ast
A structural basis for recognition of A.T and T.A base pairs in the minor groove of B-DNA
@en
A structural basis for recognition of A.T and T.A base pairs in the minor groove of B-DNA
@nl
type
label
A structural basis for recognition of A.T and T.A base pairs in the minor groove of B-DNA
@ast
A structural basis for recognition of A.T and T.A base pairs in the minor groove of B-DNA
@en
A structural basis for recognition of A.T and T.A base pairs in the minor groove of B-DNA
@nl
prefLabel
A structural basis for recognition of A.T and T.A base pairs in the minor groove of B-DNA
@ast
A structural basis for recognition of A.T and T.A base pairs in the minor groove of B-DNA
@en
A structural basis for recognition of A.T and T.A base pairs in the minor groove of B-DNA
@nl
P2093
P3181
P1433
P1476
A structural basis for recognition of A.T and T.A base pairs in the minor groove of B-DNA
@en
P2093
C L Kielkopf
J M Turner
J W Szewczyk
P B Dervan
P3181
P356
10.1126/SCIENCE.282.5386.111
P407
P577
1998-10-02T00:00:00Z