Pharmacokinetics of Py-Im polyamides depend on architecture: cyclic versus linear. - Wikidata - awgldk - TriplyDB

Pharmacokinetics of Py-Im polyamides depend on architecture: cyclic versus linear.

Pharmacokinetics of Py-Im polyamides depend on architecture: cyclic versus linear.

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Antitumor activity of a pyrrole-imidazole polyamide Binding studies of a large antiviral polyamide to a natural HPV sequence.A C-14 labeled Py-Im polyamide localizes to a subcutaneous prostate cancer tumor.Tumor xenograft uptake of a pyrrole-imidazole (Py-Im) polyamide varies as a function of cell line grafted.Synthesis of cyclic Py-Im polyamide libraries.Fluorescent probes for nucleic Acid visualization in fixed and live cells.Polyamide fluorescent probes for visualization of repeated DNA sequences in living cells.Characterization and solubilization of pyrrole-imidazole polyamide aggregates Single-dose pharmacokinetic and toxicity analysis of pyrrole-imidazole polyamides in mice.Gene expression changes in a tumor xenograft by a pyrrole-imidazole polyamide.Correlation of local effects of DNA sequence and position of β-alanine inserts with polyamide-DNA complex binding affinities and kinetics.Activity of a Py-Im polyamide targeted to the estrogen response element.Animal toxicity of hairpin pyrrole-imidazole polyamides varies with the turn unit.Androgen receptor antagonism by divalent ethisterone conjugates in castrate-resistant prostate cancer cells.Binding to the DNA minor groove by heterocyclic dications: from AT-specific monomers to GC recognition with dimers.An HRE-Binding Py-Im Polyamide Impairs Hypoxic Signaling in Tumors.Pyrrole-imidazole polyamide targeted to break fusion sites in TMPRSS2 and ERG gene fusion represses prostate tumor growth.

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P2860

Pharmacokinetics of Py-Im polyamides depend on architecture: cyclic versus linear.

http://www.wikidata.org/entity/Q35949095

description

2012 nî lūn-bûn

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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name

Pharmacokinetics of Py-Im polyamides depend on architecture: cyclic versus linear.

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Pharmacokinetics of Py-Im polyamides depend on architecture: cyclic versus linear.

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type

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Pharmacokinetics of Py-Im polyamides depend on architecture: cyclic versus linear.

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Pharmacokinetics of Py-Im polyamides depend on architecture: cyclic versus linear.

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Pharmacokinetics of Py-Im polyamides depend on architecture: cyclic versus linear.

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Pharmacokinetics of Py-Im polyamides depend on architecture: cyclic versus linear.

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Journal of the American Chemical Society

P1476

Pharmacokinetics of Py-Im polyamides depend on architecture: cyclic versus linear.

@en

P2093

Alex Y So

http://www.w3.org/2001/XMLSchema#string

Amanda E Hargrove

http://www.w3.org/2001/XMLSchema#string

Jevgenij A Raskatov

http://www.w3.org/2001/XMLSchema#string

P2860

Suppression of androgen receptor-mediated gene expression by a sequence-specific DNA-binding polyamide

Allosteric modulation of DNA by small molecules

A structural basis for recognition of A.T and T.A base pairs in the minor groove of B-DNA

The fundamental role of epigenetic events in cancer

Recognition of the DNA minor groove by pyrrole-imidazole polyamides

Recognition of the four Watson-Crick base pairs in the DNA minor groove by synthetic ligands

Cancer genes and the pathways they control

Next generation hairpin polyamides with (R)-3,4-diaminobutyric acid turn unit.

Completion of a Programmable DNA-Binding Small Molecule Library

Pharmacokinetic modeling and prediction of plasma pyrrole-imidazole polyamide concentration in rats using simultaneous urinary and biliary excretion data.

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7995-7999

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scholarly article

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10.1021/JA302588V

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18

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134

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224283149

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22509786

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