Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia.
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Open access chemical probes for epigenetic targetsCIViC databaseTargeted Disruption of the Interaction Between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase ComplexesEpigenetic stress responses induce muscle stem-cell ageing by Hoxa9 developmental signals.PTEN regulates glioblastoma oncogenesis through chromatin-associated complexes of DAXX and histone H3.3.C/EBPα creates elite cells for iPSC reprogramming by upregulating Klf4 and increasing the levels of Lsd1 and Brd4.The multifaceted functions of C/EBPα in normal and malignant haematopoiesis.The molecular mechanics of mixed lineage leukemia.Design of a fluorescent ligand targeting the S-adenosylmethionine binding site of the histone methyltransferase MLL1.Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth.WDR5 high expression and its effect on tumorigenesis in leukemia.Inhibitors of protein methyltransferases as chemical tools.Epigenomic regulation of oncogenesis by chromatin remodeling.Functional and Structural Characterization of Bub3·BubR1 Interactions Required for Spindle Assembly Checkpoint Signaling in Human Cells.Structural aspects of small-molecule inhibition of methyllysine reader proteins.Epigenetic balance of gene expression by Polycomb and COMPASS families.A TGFβ-PRMT5-MEP50 axis regulates cancer cell invasion through histone H3 and H4 arginine methylation coupled transcriptional activation and repression.Targeting human SET1/MLL family of proteins.MYC-Master Regulator of the Cancer Epigenome and Transcriptome.Chemical modulators for epigenome reader domains as emerging epigenetic therapies for cancer and inflammation.C/EBPα deregulation as a paradigm for leukemogenesis.Analysis of the interplay between all-trans retinoic acid and histone deacetylase inhibitors in leukemic cells.Discovery of a Potent, Selective, and Cell-Active Dual Inhibitor of Protein Arginine Methyltransferase 4 and Protein Arginine Methyltransferase 6.Evolution of AF6-RAS association and its implications in mixed-lineage leukemia.PRMT5 Is a Critical Regulator of Breast Cancer Stem Cell Function via Histone Methylation and FOXP1 Expression.WD40 repeat domain proteins: a novel target class?Moonlighting with WDR5: A Cellular Multitasker.Long noncoding RNA BLACAT2 promotes bladder cancer-associated lymphangiogenesis and lymphatic metastasis.Modes of Interaction of KMT2 Histone H3 Lysine 4 Methyltransferase/COMPASS Complexes with Chromatin.MLL-fusion-driven leukemia requires SETD2 to safeguard genomic integrity.WDR5 supports colon cancer cells by promoting methylation of H3K4 and suppressing DNA damage.Facile target validation in an animal model with intracellularly expressed monobodiesErratum: Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemiaNext-Generation Drugs and Probes for Chromatin Biology: From Targeted Protein Degradation to Phase SeparationKDM5 histone demethylases repress immune response via suppression of STING
P2860
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P2860
Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia.
description
2015 nî lūn-bûn
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2015 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի օգոստոսին հրատարակված գիտական հոդված
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2015年の論文
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2015年学术文章
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2015年学术文章
@zh-cn
2015年学术文章
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2015年学术文章
@zh-my
2015年学术文章
@zh-sg
2015年學術文章
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name
Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia.
@ast
Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia.
@en
Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia.
@nl
type
label
Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia.
@ast
Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia.
@en
Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia.
@nl
altLabel
Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia
@en
prefLabel
Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia.
@ast
Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia.
@en
Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia.
@nl
P2093
P2860
P50
P921
P3181
P356
P1476
Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia.
@en
P2093
Aiping Dong
Alexey Stukalov
Amit Grover
Anna Skucha
Claus Nerlov
Ekaterina Kuznetsova
Fengling Li
Gennadiy Poda
Keiryn L Bennett
P2860
P2888
P3181
P356
10.1038/NCHEMBIO.1859
P50
P577
2015-08-01T00:00:00Z
P6179
1005543649