WDR5 interacts with mixed lineage leukemia (MLL) protein via the histone H3-binding pocket
about
Regulation of HOXA2 gene expression by the ATP-dependent chromatin remodeling enzyme CHD8Structural analysis of the KANSL1/WDR5/KANSL2 complex reveals that WDR5 is required for efficient assembly and chromatin targeting of the NSL complexOn the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complexHijacked in cancer: the KMT2 (MLL) family of methyltransferasesOn WD40 proteins: propelling our knowledge of transcriptional control?A role for Set1/MLL-related components in epigenetic regulation of the Caenorhabditis elegans germ lineMolecular Mechanism of MLL PHD3 and RNA Recognition by the Cyp33 RRM DomainCharacterization of a Novel WDR5-binding Site That Recruits RbBP5 through a Conserved Motif to Enhance Methylation of Histone H3 Lysine 4 by Mixed Lineage Leukemia Protein-1Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2)Structure and function of WD40 domain proteinsSymmetric dimethylation of H3R2 is a newly identified histone mark that supports euchromatin maintenanceThe plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferasesStructure of the mitotic checkpoint complexStructural Basis for WDR5 Interaction (Win) Motif Recognition in Human SET1 Family Histone MethyltransferasesHigh-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interactionThe super elongation complex (SEC) and MLL in development and disease.Targeted Disruption of the Interaction Between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase ComplexesPharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia.The MYC-WDR5 Nexus and CancerRCC1 uses a conformationally diverse loop region to interact with the nucleosome: a model for the RCC1-nucleosome complexIMAAAGINE: a webserver for searching hypothetical 3D amino acid side chain arrangements in the Protein Data BankAn Ash2L/RbBP5 heterodimer stimulates the MLL1 methyltransferase activity through coordinated substrate interactions with the MLL1 SET domainA non-active-site SET domain surface crucial for the interaction of MLL1 and the RbBP5/Ash2L heterodimer within MLL family core complexesEpigenetic regulator MLL2 shows altered expression in cancer cell lines and tumors from human breast and colon.Mixed lineage leukemia: a structure-function perspective of the MLL1 protein.Perspectives on the discovery of small-molecule modulators for epigenetic processes.Substrate and product specificities of SET domain methyltransferasesWRAD: enabler of the SET1-family of H3K4 methyltransferases.Keeping it in the family: diverse histone recognition by conserved structural foldsIdentifying the hotspots on the top faces of WD40-repeat proteins from their primary sequences by β-bulges and DHSW tetradsStructural basis for H3K4 trimethylation by yeast Set1/COMPASS.ATX1-generated H3K4me3 is required for efficient elongation of transcription, not initiation, at ATX1-regulated genesUnderstanding the molecular manipulation of DCAF1 by the lentiviral accessory proteins Vpr and Vpx.Biochemical reconstitution and phylogenetic comparison of human SET1 family core complexes involved in histone methylationWD repeat-containing protein 5 (WDR5) localizes to the midbody and regulates abscission.Requirement for MLL3 in p53 regulation of hepatic expression of small heterodimer partner and bile acid homeostasis.Targeting protein-protein interactions in hematologic malignancies: still a challenge or a great opportunity for future therapies?Charge-based interaction conserved within histone H3 lysine 4 (H3K4) methyltransferase complexes is needed for protein stability, histone methylation, and gene expressionUnique Role of the WD-40 Repeat Protein 5 (WDR5) Subunit within the Mixed Lineage Leukemia 3 (MLL3) Histone Methyltransferase ComplexThe n-SET domain of Set1 regulates H2B ubiquitylation-dependent H3K4 methylation.
P2860
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P2860
WDR5 interacts with mixed lineage leukemia (MLL) protein via the histone H3-binding pocket
description
2008 nî lūn-bûn
@nan
2008 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
name
WDR5 interacts with mixed line ...... the histone H3-binding pocket
@ast
WDR5 interacts with mixed line ...... the histone H3-binding pocket
@en
WDR5 interacts with mixed line ...... the histone H3-binding pocket
@en-gb
WDR5 interacts with mixed line ...... the histone H3-binding pocket
@nl
type
label
WDR5 interacts with mixed line ...... the histone H3-binding pocket
@ast
WDR5 interacts with mixed line ...... the histone H3-binding pocket
@en
WDR5 interacts with mixed line ...... the histone H3-binding pocket
@en-gb
WDR5 interacts with mixed line ...... the histone H3-binding pocket
@nl
altLabel
WDR5 Interacts with Mixed Line ...... the Histone H3-binding Pocket
@en
prefLabel
WDR5 interacts with mixed line ...... the histone H3-binding pocket
@ast
WDR5 interacts with mixed line ...... the histone H3-binding pocket
@en
WDR5 interacts with mixed line ...... the histone H3-binding pocket
@en-gb
WDR5 interacts with mixed line ...... the histone H3-binding pocket
@nl
P2860
P921
P3181
P356
P1476
WDR5 interacts with mixed line ...... the histone H3-binding pocket
@en
P2093
Ji-Joon Song
Robert E Kingston
P2860
P304
P3181
P356
10.1074/JBC.M806900200
P407
P577
2008-12-12T00:00:00Z