Tyrosyl-DNA phosphodiesterase (Tdp1) participates in the repair of Top2-mediated DNA damage
about
Spinocerebellar ataxia with axonal neuropathy: consequence of a Tdp1 recessive neomorphic mutation?Novel high-throughput electrochemiluminescent assay for identification of human tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors and characterization of furamidine (NSC 305831) as an inhibitor of Tdp1Increased expression and activity of repair genes TDP1 and XPF in non-small cell lung cancerA human 5'-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damageOptimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PKTargeting DNA topoisomerase II in cancer chemotherapyCharacterization of the intracellular deproteinized relaxed circular DNA of hepatitis B virus: an intermediate of covalently closed circular DNA formationMolecular mechanisms of etoposideDrugging topoisomerases: lessons and challengesTDP2-dependent non-homologous end-joining protects against topoisomerase II-induced DNA breaks and genome instability in cells and in vivoAnalysis of the Active-Site Mechanism of Tyrosyl-DNA Phosphodiesterase I: A Member of the Phospholipase D SuperfamilyProteolytic Degradation of Topoisomerase II (Top2) Enables the Processing of Top2{middle dot}DNA and Top2{middle dot}RNA Covalent Complexes by Tyrosyl-DNA-Phosphodiesterase 2 (TDP2)Processing of damaged DNA ends for double-strand break repair in mammalian cellsNumerical analysis of etoposide induced DNA breaksTDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivoCtp1 and the MRN-complex are required for endonucleolytic Rec12 removal with release of a single class of oligonucleotides in fission yeast.Identification of phosphotyrosine mimetic inhibitors of human tyrosyl-DNA phosphodiesterase I by a novel AlphaScreen high-throughput assayIdentification of novel DNA repair proteins via primary sequence, secondary structure, and homology.Gene expression in a Drosophila model of mitochondrial disease.Sumoylation of the Rad1 nuclease promotes DNA repair and regulates its DNA associationYeast Tdp1 regulates the fidelity of nonhomologous end joining.Role of tyrosyl-DNA phosphodiesterase (TDP1) in mitochondria.MRE11 function in response to topoisomerase poisons is independent of its function in double-strand break repair in Saccharomyces cerevisiaeThe DNA binding and 3'-end preferential activity of human tyrosyl-DNA phosphodiesterase.Post-meiotic DNA double-strand breaks occur in Tetrahymena, and require Topoisomerase II and Spo11.Tyrosyl-DNA-phosphodiesterases (TDP1 and TDP2).Identification of novel PARP inhibitors using a cell-based TDP1 inhibitory assay in a quantitative high-throughput screening platform.Biochemical assays for the discovery of TDP1 inhibitorsInvolvement of the host DNA-repair enzyme TDP2 in formation of the covalently closed circular DNA persistence reservoir of hepatitis B virusesTdp2: a means to fixing the endsEffects of DNA and protein size on substrate cleavage by human tyrosyl-DNA phosphodiesterase 1.All tangled up: how cells direct, manage and exploit topoisomerase function.Tyrosyl-DNA Phosphodiesterase 1 (Tdp1) inhibitorsTyrosyl-DNA phosphodiesterase I catalytic mutants reveal an alternative nucleophile that can catalyze substrate cleavageTyrosyl-DNA phosphodiesterase 1 (TDP1) repairs DNA damage induced by topoisomerases I and II and base alkylation in vertebrate cells.TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1.How similar are enzyme active site geometries derived from quantum mechanical theozymes to crystal structures of enzyme-inhibitor complexes? Implications for enzyme design.Tyrosyl-DNA phosphodiesterase as a target for anticancer therapyStage-specific gene expression is a fundamental characteristic of rat spermatogenic cells and Sertoli cellsEnhancing drug accumulation in Saccharomyces cerevisiae by repression of pleiotropic drug resistance genes with chimeric transcription repressors.
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P2860
Tyrosyl-DNA phosphodiesterase (Tdp1) participates in the repair of Top2-mediated DNA damage
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2006 nî lūn-bûn
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2006 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2006年の論文
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2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
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name
Tyrosyl-DNA phosphodiesterase ...... ir of Top2-mediated DNA damage
@ast
Tyrosyl-DNA phosphodiesterase ...... ir of Top2-mediated DNA damage
@en
Tyrosyl-DNA phosphodiesterase ...... r of Top2-mediated DNA damage.
@nl
type
label
Tyrosyl-DNA phosphodiesterase ...... ir of Top2-mediated DNA damage
@ast
Tyrosyl-DNA phosphodiesterase ...... ir of Top2-mediated DNA damage
@en
Tyrosyl-DNA phosphodiesterase ...... r of Top2-mediated DNA damage.
@nl
prefLabel
Tyrosyl-DNA phosphodiesterase ...... ir of Top2-mediated DNA damage
@ast
Tyrosyl-DNA phosphodiesterase ...... ir of Top2-mediated DNA damage
@en
Tyrosyl-DNA phosphodiesterase ...... r of Top2-mediated DNA damage.
@nl
P2093
P2860
P921
P356
P1476
Tyrosyl-DNA phosphodiesterase ...... ir of Top2-mediated DNA damage
@en
P2093
Karin C Nitiss
Mobeen Malik
Stephen W White
Xiaoping He
P2860
P304
P356
10.1073/PNAS.0603455103
P407
P577
2006-06-13T00:00:00Z