The DNA binding and 3'-end preferential activity of human tyrosyl-DNA phosphodiesterase. - Wikidata - awgldk - TriplyDB

The DNA binding and 3'-end preferential activity of human tyrosyl-DNA phosphodiesterase.

The DNA binding and 3'-end preferential activity of human tyrosyl-DNA phosphodiesterase.

http://www.wikidata.org/entity/Q33783186

about

Biochemical characterization of human tyrosyl-DNA phosphodiesterase 2 (TDP2/TTRAP): a Mg(2+)/Mn(2+)-dependent phosphodiesterase specific for the repair of topoisomerase cleavage complexes Characterization of magnesium requirement of human 5'-tyrosyl DNA phosphodiesterase mediated reaction Analysis of the Active-Site Mechanism of Tyrosyl-DNA Phosphodiesterase I: A Member of the Phospholipase D Superfamily Tyrosyl-DNA-phosphodiesterases (TDP1 and TDP2).Identification of novel PARP inhibitors using a cell-based TDP1 inhibitory assay in a quantitative high-throughput screening platform.Biochemical assays for the discovery of TDP1 inhibitors Neuroprotection and repair of 3'-blocking DNA ends by glaikit (gkt) encoding Drosophila tyrosyl-DNA phosphodiesterase 1 (TDP1).Effects of DNA and protein size on substrate cleavage by human tyrosyl-DNA phosphodiesterase 1.Tyrosyl-DNA Phosphodiesterase 1 (Tdp1) inhibitors Tyrosyl-DNA phosphodiesterase 1 (TDP1) repairs DNA damage induced by topoisomerases I and II and base alkylation in vertebrate cells.TDP1 repairs nuclear and mitochondrial DNA damage induced by chain-terminating anticancer and antiviral nucleoside analogs.Epigenetic and genetic inactivation of tyrosyl-DNA-phosphodiesterase 1 (TDP1) in human lung cancer cells from the NCI-60 panel PARP1-TDP1 coupling for the repair of topoisomerase I-induced DNA damage.TDP1 is critical for the repair of DNA breaks induced by sapacitabine, a nucleoside also targeting ATM- and BRCA-deficient tumors.SUMO modification of the neuroprotective protein TDP1 facilitates chromosomal single-strand break repair.TDP1 promotes assembly of non-homologous end joining protein complexes on DNA.Tyrosyl-DNA phosphodiesterase 1 initiates repair of apurinic/apyrimidinic sites.Structural basis for DNA 3'-end processing by human tyrosyl-DNA phosphodiesterase 1.Reactive oxygen species stress increases accumulation of tyrosyl-DNA phsosphodiesterase 1 within mitochondria.Novel group of tyrosyl-DNA-phosphodiesterase 1 inhibitors based on disaccharide nucleosides as drug prototypes for anti-cancer therapy

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P2860

The DNA binding and 3'-end preferential activity of human tyrosyl-DNA phosphodiesterase.

http://www.wikidata.org/entity/Q33783186

description

2010 nî lūn-bûn

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2010 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հունվարին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

The DNA binding and 3'-end preferential activity of human tyrosyl-DNA phosphodiesterase.

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The DNA binding and 3'-end preferential activity of human tyrosyl-DNA phosphodiesterase.

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type

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The DNA binding and 3'-end preferential activity of human tyrosyl-DNA phosphodiesterase.

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The DNA binding and 3'-end preferential activity of human tyrosyl-DNA phosphodiesterase.

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The DNA binding and 3'-end preferential activity of human tyrosyl-DNA phosphodiesterase.

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The DNA binding and 3'-end preferential activity of human tyrosyl-DNA phosphodiesterase.

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Nucleic Acids Research

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The DNA binding and 3'-end preferential activity of human tyrosyl-DNA phosphodiesterase.

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Andrew G Stephen

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Matthew J Fivash

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Robert J Fisher

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Thomas S Dexheimer

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P2860

Molecular characterization of a human DNA kinase

Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1

Conversion of phosphoglycolate to phosphate termini on 3' overhangs of DNA double strand breaks by the human tyrosyl-DNA phosphodiesterase hTdp1

Spinocerebellar ataxia with axonal neuropathy: consequence of a Tdp1 recessive neomorphic mutation?

Novel high-throughput electrochemiluminescent assay for identification of human tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors and characterization of furamidine (NSC 305831) as an inhibitor of Tdp1

TDP1 facilitates repair of ionizing radiation-induced DNA single-strand breaks

A human 5'-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damage

Complex interactions of HIV-1 nucleocapsid protein with oligonucleotides

The tyrosyl-DNA phosphodiesterase Tdp1 is a member of the phospholipase D superfamily

Targeting DNA topoisomerase II in cancer chemotherapy

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10.1093/NAR/GKP1206

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20097655

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