Yeast cystathionine beta-synthase is a pyridoxal phosphate enzyme but, unlike the human enzyme, is not a heme protein.
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CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutationsStructural basis of regulation and oligomerization of human cystathionine -synthase, the central enzyme of transsulfurationStopped-flow kinetic analysis of the reaction catalyzed by the full-length yeast cystathionine beta-synthase.Characterization of transsulfuration and cysteine biosynthetic pathways in the protozoan hemoflagellate, Trypanosoma cruzi. Isolation and molecular characterization of cystathionine beta-synthase and serine acetyltransferase from TrypanosomaMolecular characterization of a cystathionine beta-synthase gene, CBS1, in Magnaporthe grisea.Pre-steady-state kinetic analysis of enzyme-monitored turnover during cystathionine β-synthase-catalyzed H(2)S generationS-glutathionylation enhances human cystathionine β-synthase activity under oxidative stress conditions.PLP-dependent H(2)S biogenesis.Novel structural arrangement of nematode cystathionine β-synthases: characterization of Caenorhabditis elegans CBS-1.Purification, crystallization and preliminary crystallographic analysis of the full-length cystathionine β-synthase from Apis melliferaProperties of an unusual heme cofactor in PLP-dependent cystathionine beta-synthase.Kinetics of reversible reductive carbonylation of heme in human cystathionine β-synthase.Heme regulation of human cystathionine beta-synthase activity: insights from fluorescence and Raman spectroscopy.Modulation of the heme electronic structure and cystathionine beta-synthase activity by second coordination sphere ligands: The role of heme ligand switching in redox regulation.Purification, crystallization and preliminary crystallographic analysis of the catalytic core of cystathionine β-synthase from Saccharomyces cerevisiae.Active cystathionine beta-synthase can be expressed in heme-free systems in the presence of metal-substituted porphyrins or a chemical chaperone.Comparative study of enzyme activity and heme reactivity in Drosophila melanogaster and Homo sapiens cystathionine β-synthases.Cobalt cystathionine β-synthase: a cobalt-substituted heme protein with a unique thiolate ligation motif.Purification and characterization of the wild type and truncated human cystathionine beta-synthase enzymes expressed in E. coli.Pyridoxal phosphate binding sites are similar in human heme-dependent and yeast heme-independent cystathionine beta-synthases. Evidence from 31P NMR and pulsed EPR spectroscopy that heme and PLP cofactors are not proximal in the human enzyme.Cystathionine beta-synthase is coordinately regulated with proliferation through a redox-sensitive mechanism in cultured human cells and Saccharomyces cerevisiae.Deletion mutagenesis of human cystathionine beta-synthase. Impact on activity, oligomeric status, and S-adenosylmethionine regulation.Investigation of residues Lys112, Glu136, His138, Gly247, Tyr248, and Asp249 in the active site of yeast cystathionine beta-synthase.Potential Pharmacological Chaperones for Cystathionine Beta-Synthase-Deficient Homocystinuria.Chemical Biology of H2S Signaling through Persulfidation.Crystallographic and mutational analyses of cystathionine β-synthase in the H2 S-synthetic gene cluster in Lactobacillus plantarum.
P2860
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P2860
Yeast cystathionine beta-synthase is a pyridoxal phosphate enzyme but, unlike the human enzyme, is not a heme protein.
description
2000 nî lūn-bûn
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2000年の論文
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Yeast cystathionine beta-synth ...... enzyme, is not a heme protein.
@ast
Yeast cystathionine beta-synth ...... enzyme, is not a heme protein.
@en
Yeast cystathionine beta-synth ...... enzyme, is not a heme protein.
@nl
type
label
Yeast cystathionine beta-synth ...... enzyme, is not a heme protein.
@ast
Yeast cystathionine beta-synth ...... enzyme, is not a heme protein.
@en
Yeast cystathionine beta-synth ...... enzyme, is not a heme protein.
@nl
prefLabel
Yeast cystathionine beta-synth ...... enzyme, is not a heme protein.
@ast
Yeast cystathionine beta-synth ...... enzyme, is not a heme protein.
@en
Yeast cystathionine beta-synth ...... enzyme, is not a heme protein.
@nl
P2093
P2860
P356
P1476
Yeast cystathionine beta-synth ...... enzyme, is not a heme protein.
@en
P2093
P2860
P304
P356
10.1074/JBC.C000056200
P407
P577
2000-04-21T00:00:00Z