Deletion mutagenesis of human cystathionine beta-synthase. Impact on activity, oligomeric status, and S-adenosylmethionine regulation.
about
Human cystathionine β-synthase (CBS) contains two classes of binding sites for S-adenosylmethionine (SAM): complex regulation of CBS activity and stability by SAMModulation of cystathionine beta-synthase activity by the Arg-51 and Arg-224 mutationsCharacterization of two pathogenic mutations in cystathionine beta-synthase: different intracellular locations for wild-type and mutant proteinsCBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutationsReduced MTHFD1 activity in male mice perturbs folate- and choline-dependent one-carbon metabolism as well as transsulfurationRescue of cystathionine beta-synthase (CBS) mutants with chemical chaperones: purification and characterization of eight CBS mutant enzymes.Effect of S-adenosyl-L-methionine (SAM), an allosteric activator of cystathionine-β-synthase (CBS) on colorectal cancer cell proliferation and bioenergetics in vitro.Purification and characterization of cystathionine β-synthase bearing a cobalt protoporphyrin.Effect of the disease-causing R266K mutation on the heme and PLP environments of human cystathionine β-synthase.S-Adenosylhomocysteine hydrolase deficiency: a second patient, the younger brother of the index patient, and outcomes during therapyMono and dual cofactor dependence of human cystathionine β-synthase enzyme variants in vivo and in vitro.Heme regulation of human cystathionine beta-synthase activity: insights from fluorescence and Raman spectroscopy.Hypermethioninemias of genetic and non-genetic origin: A review.Active cystathionine beta-synthase can be expressed in heme-free systems in the presence of metal-substituted porphyrins or a chemical chaperone.Comparative study of enzyme activity and heme reactivity in Drosophila melanogaster and Homo sapiens cystathionine β-synthases.Cobalt cystathionine β-synthase: a cobalt-substituted heme protein with a unique thiolate ligation motif.Cystathionine β-synthase (CBS) domains confer multiple forms of Mg2+-dependent cooperativity to family II pyrophosphatases.Purification and characterization of the wild type and truncated human cystathionine beta-synthase enzymes expressed in E. coli.Cross-talk between the catalytic core and the regulatory domain in cystathionine β-synthase: study by differential covalent labeling and computational modeling.Reduced response of Cystathionine Beta-Synthase (CBS) to S-Adenosylmethionine (SAM): Identification and functional analysis of CBS gene mutations in Homocystinuria patients.Heme interaction of the intrinsically disordered N-terminal peptide segment of human cystathionine-β-synthase.
P2860
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P2860
Deletion mutagenesis of human cystathionine beta-synthase. Impact on activity, oligomeric status, and S-adenosylmethionine regulation.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh-hant
name
Deletion mutagenesis of human ...... adenosylmethionine regulation.
@en
Deletion mutagenesis of human ...... adenosylmethionine regulation.
@nl
type
label
Deletion mutagenesis of human ...... adenosylmethionine regulation.
@en
Deletion mutagenesis of human ...... adenosylmethionine regulation.
@nl
prefLabel
Deletion mutagenesis of human ...... adenosylmethionine regulation.
@en
Deletion mutagenesis of human ...... adenosylmethionine regulation.
@nl
P2093
P2860
P356
P1476
Deletion mutagenesis of human ...... adenosylmethionine regulation.
@en
P2093
Jan P Kraus
Jana Oliveriusová
Kenneth N Maclean
Vladimír Kery
P2860
P304
48386-48394
P356
10.1074/JBC.M207087200
P407
P577
2002-10-11T00:00:00Z