Lcd1p recruits Mec1p to DNA lesions in vitro and in vivo.
about
Krüppel-like factor 4 regulates genetic stability in mouse embryonic fibroblastsATRIP binding to replication protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylationDynamics of DNA damage response proteins at DNA breaks: a focus on protein modificationsRapid activation of ATR by ionizing radiation requires ATM and Mre11Biochemical characterization of DNA damage checkpoint complexes: clamp loader and clamp complexes with specificity for 5' recessed DNAMdt1, a novel Rad53 FHA1 domain-interacting protein, modulates DNA damage tolerance and G(2)/M cell cycle progression in Saccharomyces cerevisiae.Separation-of-function mutants of yeast Ku80 reveal a Yku80p-Sir4p interaction involved in telomeric silencing.Tel2 mediates activation and localization of ATM/Tel1 kinase to a double-strand break.An N-terminal acidic region of Sgs1 interacts with Rpa70 and recruits Rad53 kinase to stalled forks.Yeast Rad17/Mec3/Ddc1: a sliding clamp for the DNA damage checkpoint.Phosphorylation of the budding yeast 9-1-1 complex is required for Dpb11 function in the full activation of the UV-induced DNA damage checkpoint.Dpb11 coordinates Mec1 kinase activation with cell cycle-regulated Rad9 recruitmentThe C-terminal residues of Saccharomyces cerevisiae Mec1 are required for its localization, stability, and function.Yeast DNA replication protein Dpb11 activates the Mec1/ATR checkpoint kinaseRole of Dot1-dependent histone H3 methylation in G1 and S phase DNA damage checkpoint functions of Rad9.Saccharomyces cerevisiae Sin3p facilitates DNA double-strand break repair.Limiting amounts of budding yeast Rad53 S-phase checkpoint activity results in increased resistance to DNA alkylation damageQuaternary structure of ATR and effects of ATRIP and replication protein A on its DNA binding and kinase activitiesConserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damageThe yeast DNA damage checkpoint proteins control a cytoplasmic response to DNA damageYeast Rad52 and Rad51 recombination proteins define a second pathway of DNA damage assessment in response to a single double-strand break.The meiosis-specific protein kinase Ime2 directs phosphorylation of replication protein A.A novel protein activity mediates DNA binding of an ATR-ATRIP complex.DNA stimulates Mec1-mediated phosphorylation of replication protein A.Amino-terminal domain of ATRIP contributes to intranuclear relocation of the ATR-ATRIP complex following DNA damage.Role of the C terminus of Mec1 checkpoint kinase in its localization to sites of DNA damage.Recruitment of DNA damage checkpoint proteins to damage in transcribed and nontranscribed sequences.Replisome instability, fork collapse, and gross chromosomal rearrangements arise synergistically from Mec1 kinase and RecQ helicase mutations.ATRIP associates with replication protein A-coated ssDNA through multiple interactions.Replication protein A directs loading of the DNA damage checkpoint clamp to 5'-DNA junctions.The checkpoint clamp activates Mec1 kinase during initiation of the DNA damage checkpoint.Function of a conserved checkpoint recruitment domain in ATRIP proteins.Roles of the checkpoint sensor clamp Rad9-Rad1-Hus1 (911)-complex and the clamp loaders Rad17-RFC and Ctf18-RFC in Schizosaccharomyces pombe telomere maintenanceColocalization of sensors is sufficient to activate the DNA damage checkpoint in the absence of damageSlx4 regulates DNA damage checkpoint-dependent phosphorylation of the BRCT domain protein Rtt107/Esc4Distribution and dynamics of chromatin modification induced by a defined DNA double-strand breakCcr4-not complex mRNA deadenylase activity contributes to DNA damage responses in Saccharomyces cerevisiae.Reduced Rif2 and lack of Mec1 target short telomeres for elongation rather than double-strand break repair.Coordination of DNA synthesis and replicative unwinding by the S-phase checkpoint pathways.Ddc2 mediates Mec1 activation through a Ddc1- or Dpb11-independent mechanism
P2860
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P2860
Lcd1p recruits Mec1p to DNA lesions in vitro and in vivo.
description
2002 nî lūn-bûn
@nan
2002 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Lcd1p recruits Mec1p to DNA lesions in vitro and in vivo.
@ast
Lcd1p recruits Mec1p to DNA lesions in vitro and in vivo.
@en
Lcd1p recruits Mec1p to DNA lesions in vitro and in vivo.
@nl
type
label
Lcd1p recruits Mec1p to DNA lesions in vitro and in vivo.
@ast
Lcd1p recruits Mec1p to DNA lesions in vitro and in vivo.
@en
Lcd1p recruits Mec1p to DNA lesions in vitro and in vivo.
@nl
prefLabel
Lcd1p recruits Mec1p to DNA lesions in vitro and in vivo.
@ast
Lcd1p recruits Mec1p to DNA lesions in vitro and in vivo.
@en
Lcd1p recruits Mec1p to DNA lesions in vitro and in vivo.
@nl
P1433
P1476
Lcd1p recruits Mec1p to DNA lesions in vitro and in vivo.
@en
P2093
John Rouse
P304
P356
10.1016/S1097-2765(02)00507-5
P407
P577
2002-04-01T00:00:00Z