Phosphorylation of the budding yeast 9-1-1 complex is required for Dpb11 function in the full activation of the UV-induced DNA damage checkpoint.
about
RPA-coated single-stranded DNA as a platform for post-translational modifications in the DNA damage responseMechanisms and regulation of mitotic recombination in Saccharomyces cerevisiaeSlx4 and Rtt107 control checkpoint signalling and DNA resection at double-strand breaks.Dpb11 coordinates Mec1 kinase activation with cell cycle-regulated Rad9 recruitmentYeast DNA replication protein Dpb11 activates the Mec1/ATR checkpoint kinaseSensing of replication stress and Mec1 activation act through two independent pathways involving the 9-1-1 complex and DNA polymerase εPhosphorylation-dependent interactions between Crb2 and Chk1 are essential for DNA damage checkpointAssembly of Slx4 signaling complexes behind DNA replication forksSite-specific phosphorylation of the DNA damage response mediator rad9 by cyclin-dependent kinases regulates activation of checkpoint kinase 1A truncated DNA-damage-signaling response is activated after DSB formation in the G1 phase of Saccharomyces cerevisiae.Preserving Yeast Genetic Heritage through DNA Damage Checkpoint Regulation and Telomere Maintenance.Multiple regulatory mechanisms to inhibit untimely initiation of DNA replication are important for stable genome maintenance.Synaptonemal complex formation and meiotic checkpoint signaling are linked to the lateral element protein Red1.Dynamics of Rad9 chromatin binding and checkpoint function are mediated by its dimerization and are cell cycle-regulated by CDK1 activityThe Rad4(TopBP1) ATR-activation domain functions in G1/S phase in a chromatin-dependent manner.Maintenance of the DNA-damage checkpoint requires DNA-damage-induced mediator protein oligomerization.Ddc2 mediates Mec1 activation through a Ddc1- or Dpb11-independent mechanismCell biology of mitotic recombination.Phosphoproteomics reveals distinct modes of Mec1/ATR signaling during DNA replicationFunctional interplay between the 53BP1-ortholog Rad9 and the Mre11 complex regulates resection, end-tethering and repair of a double-strand break.The unstructured C-terminal tail of yeast Dpb11 (human TopBP1) protein is dispensable for DNA replication and the S phase checkpoint but required for the G2/M checkpoint.Dampening DNA damage checkpoint signalling via coordinated BRCT domain interactions.Colocalization of Mec1 and Mrc1 is sufficient for Rad53 phosphorylation in vivo.Yet another job for Dna2: Checkpoint activation.Termination of Replication Stress Signaling via Concerted Action of the Slx4 Scaffold and the PP4 PhosphataseDNA-repair scaffolds dampen checkpoint signalling by counteracting the adaptor Rad9Lagging strand maturation factor Dna2 is a component of the replication checkpoint initiation machineryDpb11 activates the Mec1-Ddc2 complexA tale of two tails: activation of DNA damage checkpoint kinase Mec1/ATR by the 9-1-1 clamp and by Dpb11/TopBP1.The unstructured C-terminal tail of the 9-1-1 clamp subunit Ddc1 activates Mec1/ATR via two distinct mechanisms.Perspectives on the DNA damage and replication checkpoint responses in Saccharomyces cerevisiae.The histone methyltransferase Dot1/DOT1L as a critical regulator of the cell cycle.Cell-cycle-specific activators of the Mec1/ATR checkpoint kinase.Mind the gap: keeping UV lesions in check.Eukaryotic DNA damage checkpoint activation in response to double-strand breaks.DNA damage sensing by the ATM and ATR kinases.Multi-BRCT scaffolds use distinct strategies to support genome maintenance.Nuclear DNA replication and repair in parasites of the genus Leishmania: Exploiting differences to develop innovative therapeutic approaches.S-phase checkpoint regulations that preserve replication and chromosome integrity upon dNTP depletion.Control of Mus81 nuclease during the cell cycle.
P2860
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P2860
Phosphorylation of the budding yeast 9-1-1 complex is required for Dpb11 function in the full activation of the UV-induced DNA damage checkpoint.
description
2008 nî lūn-bûn
@nan
2008 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Phosphorylation of the budding ...... induced DNA damage checkpoint.
@ast
Phosphorylation of the budding ...... induced DNA damage checkpoint.
@en
Phosphorylation of the budding ...... induced DNA damage checkpoint.
@nl
type
label
Phosphorylation of the budding ...... induced DNA damage checkpoint.
@ast
Phosphorylation of the budding ...... induced DNA damage checkpoint.
@en
Phosphorylation of the budding ...... induced DNA damage checkpoint.
@nl
prefLabel
Phosphorylation of the budding ...... induced DNA damage checkpoint.
@ast
Phosphorylation of the budding ...... induced DNA damage checkpoint.
@en
Phosphorylation of the budding ...... induced DNA damage checkpoint.
@nl
P2093
P2860
P50
P921
P356
P1476
Phosphorylation of the budding ...... induced DNA damage checkpoint.
@en
P2093
Alessia Balestrini
Gabriele Piergiovanni
Lisa Di Nola
Magda Granata
P2860
P304
P356
10.1128/MCB.00330-08
P407
P577
2008-08-01T00:00:00Z